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2010-01-20 13:14:32

Scientists at Duke University Medical Center have found some compounds that improve a cell's ability to properly "fold" proteins and could lead to promising drugs for degenerative nerve diseases, including Huntington's disease, Alzheimer's disease and Parkinson's disease. Misfolded proteins in nerve cells (neurons) are a common factor in all of these diseases. The Duke team has identified many new chemicals that activate a master regulator to increase the supply of "protein chaperone"...

2010-01-06 07:59:00

CARLSBAD, Calif., Jan. 6 /PRNewswire/ -- GenVault Corporation, the leader in ambient temperature biosample stabilization, announces the launch of GenTegra(TM) RNA. GenTegra(TM) RNA is an inert chemical matrix that inactivates trace RNase in the liquid phase, providing an added level of RNA stability during sample handling, with or without ice. In the dry-state, GenTegra(TM) preserves RNA integrity by protecting samples from hydrolysis and oxidation, imparts thermal stability at...

2010-01-04 14:33:28

A team of researchers is being recognized for devising a new way to study a human protein that long has evaded close scrutiny by scientists investigating its role in the communication of important genetic messages inside a cell's nucleus to workhorse molecules found elsewhere. Last year, the team, led by J. Andrew Hockert, at the time a doctoral researcher at the Texas Tech University Health Science Center School of Medicine, put in its crosshairs the protein known as CstF-64. Today, in what...

2009-12-28 17:03:39

Just like teenagers at a prom, proteins are tended by chaperones whose job it is to prevent unwanted interactions among immature clients. And at the molecular level, just as at the high school gym level, it's a job that usually requires a lot of energy. In new research, scientists at the University of Michigan and Howard Hughes Medical Institute have discovered how a protein chaperone called HdeA, which helps protect bacteria like the notorious Escherichia coli from the ravages of stomach...

2009-11-04 15:00:26

A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. This is the finding of a research collaboration involving Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory (CSHL) and scientists from Paratek Pharmaceuticals and Rosalind Franklin University of Medicine and Science. SMA is caused by mutations in a gene called Survival of Motor Neuron 1...

2009-11-03 15:45:38

Scientists find new evolutionary mechanism that takes advantage of inefficient selection A painstaking analysis of thousands of genes and the proteins they encode shows that human beings are biologically complex, at least in part, because of the way humans evolved to cope with redundancies arising from duplicate genes. "We have found a specific evolutionary mechanism to account for a portion of the intricate biological complexity of our species," said Ariel Fernandez, professor of...

2009-10-23 13:56:38

A novel protein structure involved in hereditary neurodegeneration Fragile X tremor/ataxia syndrome (FXTAS) is a recently recognized condition, which is actually one of the most prevalent heritable neurodegenerative diseases. It is assumed that the condition is caused by deficiency for the protein Pur-alpha, which is essential for normal neural function. Structural studies undertaken by a team under the leadership of Dr. Dierk Niessing of the Helmholtz Zentrum Mnchen and the Gene Center at...

2009-10-22 14:27:58

Scientists who study RNA have faced a formidable roadblock: trying to examine RNA's movements in a living cell when they can't see the RNA. Now, a new technology has given scientists the first look ever at RNA in a live bacteria cell"”a sight that could offer new information about how the molecule moves and works. Interest in RNA, which plays a key role in manufacturing proteins, has increased in recent years, due in large part to its potential in new drug therapies. RNA localization...

2009-10-19 13:11:20

Researchers have previously been able to analyze which sugar structures are to be found on certain proteins, but not exactly where on the protein they are positioned. This is now possible thanks to a new technique developed at the Sahlgrenska Academy at the University of Gothenburg, Sweden. The technique entails preparing samples in a new way and is a development of applied mass spectrometry. Presented in the latest issue of renowned journal Nature Methods, the technique will enable medical...

2009-10-12 15:06:03

In new papers appearing this month in Science and the Proceedings of the National Academy of Sciences, University of Illinois biochemistry professor Raven H. Huang and his colleagues describe the first RNA repair system to be discovered in bacteria. This is only the second RNA repair system discovered to date (with two proteins from T4 phage, a virus that attacks bacteria, as the first). The novelty of the newly discovered bacterial RNA repair system is that, before the damaged RNA is sealed,...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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