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2009-03-11 07:23:01

A new study of proteins, the molecular machines that drive all life, also sheds light on the history of living organisms.The study, in the journal Structure, reveals that after eons of gradual evolution, proteins suddenly experienced a "big bang" of innovation. The active regions of many proteins, called domains, combined with each other or split apart to produce a host of structures that had never been seen before. This explosion of new forms coincided with the rapidly increasing diversity...

2009-02-10 08:51:54

A new way to direct chemical modifications to specific sites on recombinant proteins "“ including the monoclonal antibodies so important in the pharmaceutical industry "“ has been developed by Carolyn Bertozzi and her colleagues at the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California at Berkeley.Many therapeutic proteins, including insulin for diabetes, can be made in bacterial systems like Escherichia coli, but most protein...

2009-02-09 07:45:54

Findings may lead to novel treatments for diseases resistant to current RNAi A team of researchers led by Rutgers' Samuel Gunderson has developed a novel gene silencing platform with very significant improvements over existing RNAi approaches. This may enable the development and discovery of a new class of drugs to treat a wide array of diseases. Critical to the technology is the approach this team took to specifically target RNA biosynthesis. The research findings are reported in the journal...

2009-01-29 08:58:51

U1, which guides the cell's RNA splicing machinery, 'slides' one RNA base, explaining a mysterious mutationTwo molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia (PCH). The new findings were published online, ahead of print, on January 25th in the journal Nature Structural and Molecular Biology.Typically striking during early...

2008-12-05 09:37:58

The Stowers Institute's Baumann Lab has discovered an important step in the maturation pathway of telomerase, the enzyme that replenishes the sequences that are lost at chromosome ends with every cell division. The findings were published today in the Advance Online Publication of Nature.     Telomerase is viewed as a promising cancer treatment target because its inhibition selectively kills cancer cells. In order to identify small molecules that block telomerase, it is...

2008-12-03 13:57:32

A U.S. geneticist says he has created an online database that can, without charge, provide scientists around the world with a tool for protein analyses. Stanford University School of Medicine Associate Professor Arend Sidow recently launched his bioinformatics tool, which enlists evolution as the guide to determining the role different proteins play in a wide array of organisms. The database called ProPhylER enables a researcher studying a protein, or the gene coding for it, to more easily...

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2008-12-02 09:54:04

Scientists around the world may benefit from a powerful new database, available for free online, that will help them to home in on the parts of proteins most necessary for their function. Arend Sidow, PhD, associate professor of pathology and of genetics at the Stanford University School of Medicine, recently launched the novel bioinformatics tool, which enlists evolution as the guide to determining the role different proteins play in a wide array of organisms. ProPhylER, which Sidow has been...

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2008-11-19 15:45:00

Scientists exploring new compounds to target muscular dystrophy Scientists have identified a promising set of new compounds in the fight against muscular dystrophy. Using a drug-discovery technique in which molecules compete against each other for access to the target "“ the strand of toxic RNA that causes the most common form of muscular dystrophy in adults "“ a team at the University of Rochester Medical Center has identified several compounds that, in the...

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2008-08-21 17:50:00

A new study of the ribosome, the cell's protein-building machinery, sheds light on the oldest branches of the evolutionary tree of life and suggests that differences in ribosomal structure between the three main branches of that tree are "molecular fossils" of the early evolution of protein synthesis. The new analysis, from researchers at the University of Illinois, reveals that key regions of the ribosome differ between bacteria and archaea, microbes that the researchers say are genetically...

2008-06-24 15:02:18

By JUDY SIEGEL-ITZKOVICH The end of the school year is upon us, and Beterem - the National Center for Child Safety and Health - is worried about accidents among children and teenagers. It and the Health Ministry have launched an information campaign to raise awareness among parents and children, as the summer months invariably mean a rise in injury and deaths in this age group from road accidents, choking, poisoning, falls, drownings and other incidents. In 2007, a total of 121...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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