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Latest Luciferase Stories

c1388fc4727405821e7b74e0ea9a02f51
2011-02-13 08:51:32

Lynn Yarris, Berkeley Lab A unique new probe based on luciferase, the enzyme that gives fireflies their glow, enables researchers to monitor  hydrogen peroxide levels in mice and thereby track the progression of infectious diseases or cancerous tumors without harming the animals or even having to shave their fur. Developed by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley, this new bioluminescent probe has already...

2011-02-09 14:45:05

The enzyme that makes fireflies glow is lighting up the scientific path toward a long-sought new medical imaging agent to better monitor treatment with heparin, the blood thinner that millions of people take to prevent or treat blood clots, scientists are reporting. Their study appears in the ACS' monthly journal Bioconjugate Chemistry. Bruce Branchini and colleagues describe a need for new medical imaging agents that emit near-infrared light "” the light rays that "night vision"...

2010-12-23 00:00:54

The new Renilla-Gloâ“ž¢ Luciferase Assay brings the convenience of the "add, mix, measure" assay format to applications using the sea pansy (Renilla reniformis) luciferase. Madison, WI (PRWEB) December 22, 2010 The new Renilla-Gloâ“ž¢ Luciferase Assay brings the convenience of the "add, mix, measure" assay format to applications using the sea pansy (Renilla reniformis) luciferase. The assay is ideal for screening in applications...

2010-12-17 07:41:05

(Ivanhoe Newswire) -- If you regularly experience the pangs of jet lag or a crazy work schedule, then you may not be the biggest fan of your body's biological clock.  Fortunately, a new molecular compound dubbed "longdaysin" has recently shown the ability to trick it into slowing down or speeding up to potentially meet different needs. Researchers at the University of California San Diego and three other research centers found longdaysin by conducting an automated screening of over...

2010-12-15 15:38:55

In a proof of principal study in mice, scientists at Johns Hopkins and the Virginia Commonwealth University (VCU) have shown that a set of genetic instructions encased in a nanoparticle can be used as an "ignition switch" to rev up gene activity that aids cancer detection and treatment. The switch, called a promoter, is a set of chemical letters that interacts with DNA to turn on gene activity. In this case, the scientists used a promoter called PEG-Prom, cloned by VCU researcher Paul Fisher,...

2010-03-30 14:16:19

Mindin has an indispensable role in both innate and adaptive immunity. A research group in China investigated regulation of mindin expression and the signaling pathway involved. mRNA expression of mindin was upregulated during dextran sulfate sodium induced mouse intestinal inflammation. Stimulation with CpG-ODN (a known TLR-9 ligand) induced upregulation of mindin expression in RAW 264.7 cells and significantly increased the NF-ÃŽºB-luciferase activity in vitro. Body of...

2009-03-16 06:45:00

GAITHERSBURG, Md., March 16 /PRNewswire/ -- Scientists who want to ensure reliable chemiluminescent sensitivity and specificity measurements for their tests should consider the MicroLumi-L2 glow microplate luminometer, the successor to the popular MicroLumi-XS luminometer, and the LRM168-96 Luminometer Reference Microplate, both designed and manufactured in the USA by Harta Instruments, Gaithersburg, MD. Both instruments are designed to exacting quality standards with ruggedness, precision,...

2009-02-03 08:47:24

A study by National Institutes of Health (NIH) researchers has revealed surprising new insights into the process used to initially identify an experimental drug now being tested in people with cystic fibrosis and muscular dystrophy. Researchers emphasized that the clinical implications of their findings are unclear, but said the results suggest more work may be needed to make sure the screening process to select promising agents was not flawed by its effects on a firefly enzyme used as a...

2008-10-05 03:00:07

By Fleshker, Shimrit Preise, Dina; Kalchenko, Vyacheslav; Scherz, Avigdor; Salomon, Yoram ABSTRACT This study hypothesized that success rate assessment of vascular targeted photodynamic therapy (VTP) of solid tumors 24 h posttreatment may allow prompt administration of a second treatment in case of failure, increasing the overall success rate. Here, we show that treatment of luciferase transfected CT26-luc mouse colon carcinoma tumors in BALB/c mice by VTP with WST11 (a Pd-...

2008-09-24 03:00:12

By Yeom, Chan Joo Chung, June-Key; Kang, Joo Hyun; Jeon, Yong Hyun; Kim, Kwang Il; Jin, Yong Nan; Lee, You Mie; Jeong, Jae Min; Lee, Dong Soo Hypoxia-inducible factor-1 (HIF-1) is a transcription factor of hypoxic response in cancer cells and is associated with tumor progression, angiogenesis, metastasis, and resistance to therapy. We assessed whether the human sodium iodide symporter (NIS) reporter systems can be used to visualize transcriptional activation of HIF- 1 in C6 glioma. Methods:...


Latest Luciferase Reference Libraries

40_2bf0663f4bacf759afeaefb7e4f01443
2005-09-08 12:01:05

Fireflies, also known as lightning bugs, are nocturnal, luminous beetles of the family Lampyridae. These names come from the fact that some species as adults emit flashes of light to attract mates, using special light-emitting organs in the abdomen. The enzyme luciferase acts on luciferin to stimulate light emission. This reaction is of scientific interest, and genes coding for these substances have been spliced into many different organisms. Many species, especially in the genus Photinus,...

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Word of the Day
reremouse
  • A bat.
The word 'reremouse' comes from Middle English reremous, from Old English hrēremūs, hrērmūs ("bat"), equivalent to rear (“to move, shake, stir”) +‎ mouse.
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