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Last updated on April 17, 2014 at 15:26 EDT

Latest Ludwig Institute Stories

2014-01-06 08:25:22

NEW YORK, Jan. 6, 2014 /PRNewswire/ -- Cancer research in the U.S. got a critical boost today as the six Ludwig Centers at Johns Hopkins University, Harvard University, the Massachusetts Institute of Technology, Memorial Sloan-Kettering Cancer Center, Stanford University and the University of Chicago received a total of $540 million as part of a gift from Ludwig Cancer Research, on behalf of its founder, Daniel K. Ludwig. This new funding ranks among the largest private philanthropic...

2013-11-04 08:27:39

TUBINGEN, Germany, and NEW YORK, Nov. 4, 2013 /PRNewswire/ -- The non-profit Cancer Research Institute (CRI) and Ludwig Cancer Research (Ludwig), and CureVac, a clinical stage biopharmaceutical company that has pioneered the development of a new class of therapies and vaccines based on messenger RNA (mRNA), today announced that they will collaborate to enable clinical testing of novel cancer immunotherapy treatment options. Amplifying the immune system's ability to recognize, attack,...

2012-10-09 07:29:00

NEW YORK and GAITHERSBURG, Md., Oct. 9, 2012 /PRNewswire/ -- The Cancer Research Institute (CRI), the Ludwig Institute for Cancer Research and MedImmune, the global biologics arm of AstraZeneca, today announced that they have signed a collaboration agreement to advance the research of immunotherapy in cancer. Specifically, the research will focus on clinical trials to test novel combinations of immunotherapies, including three investigational monoclonal antibodies from MedImmune's pipeline....

2012-09-26 10:23:53

MELBOURNE, Australia, Sept. 26, 2012 /PRNewswire/ -- CSL Limited has developed a new drug candidate that is able to prevent the development of type 2 diabetes and reverse its progression in animal models of the disease. The drug candidate blocks signalling by a protein known as Vascular Endothelial Growth Factor B (VEGF-B) and this prevents fat from accumulating in the "wrong" places, such as in muscles and in the heart. As a result, cells within these tissues are once again able to respond...

2012-08-02 15:26:11

The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer. In a study published online this week in the Proceedings of the National Academy of Sciences, scientists at the Ludwig Institute for Cancer Research in Oxford discovered a critical molecular switch that regulates autophagy. They also studied the links between autophagy...

2012-07-23 20:39:37

Applications include studying single cells that form malignant tumors Only by viewing a Seurat painting at close range can you appreciate the hidden complexities of pointillism — small, distinct dots of pure color applied in patterns to form an image from a distance. Similarly, biologists and geneticists have long sought to analyze profiles of genes at the single cell level but technology limitations have only allowed a view from afar until now. Research published in the July 22...

2012-05-18 02:20:26

Imagine reading an entire book, but then realizing that your glasses did not allow you to distinguish "g" from "q." What details did you miss? Geneticists faced a similar problem with the recent discovery of a "sixth nucleotide" in the DNA alphabet. Two modifications of cytosine, one of the four bases that make up DNA, look almost the same but mean different things. But scientists lacked a way of reading DNA, letter by letter, and detecting precisely where these modifications are found in...

2012-04-11 22:33:34

Findings provide tools for better understanding of the human genome Chromosomes are strands of DNA that contain the blueprint of all living organisms. Humans have 23 pairs of chromosomes that instruct how genes are regulated during development of the human body. While scientists have developed an understanding of the one-dimensional structure of DNA, until today, little was known about how different parts of DNA are folded next to each other inside the nucleus. Using a powerful DNA...

2012-03-08 13:43:48

Study describes a rare case of the abscopal effect in a melanoma patient Research published today in the New England Journal of Medicine by scientists at the Ludwig Institute for Cancer Research (LICR) and Memorial Sloan-Kettering Cancer Center (MSKCC) showed that combining targeted radiation therapy with immunotherapy (ipilimumab), fostered a strong immune response and a favorable clinical outcome in a patient with melanoma, the most dangerous form of skin cancer. The size of both the...

2012-01-31 11:10:44

TDO enzyme enables tumors to avoid detection and rejection by the immune system Scientists from the Ludwig Institute for Cancer Research (LICR) in Brussels identified a new target for cancer therapy, an enzyme which prevents the immune system from recognizing and destroying certain types of tumors. Called tryptophan 2,3-dioxygenase or TDO, the enzyme works by depriving immune cells of tryptophan, an amino acid essential to their activity. TDO is produced by a significant number of human...