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Latest Lymphocyte Stories

2010-09-07 19:08:28

Retinoic acid (RA), a natural derivative of vitamin A, is the basis of a number of treatments against cancer. Nevertheless, it has certain disadvantages, such as the possibility of the appearance of retinoic acid syndrome, present in 25 % of cases and which can lead to death. The development of 4-HPR, a synthetic derivative of RA, has meant a considerable advance due to its greater efficacy compared to its predecessor. It is able to induce the death of tumour cells as the method for reducing...

2010-08-17 16:49:41

Potential application for stem cell therapies Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation. The details of this collaborative study between Johns Hopkins, Stanford and Harvard appear August 15 in the early online publication of Nature. The researchers, using blood-forming...

2010-08-03 13:26:43

Researchers at the Stanford University School of Medicine have challenged decades of accepted wisdom about bone marrow transplantation with a new study showing that mice receiving purified blood stem cells are less prone to complications than mice receiving stem cells plus purified T cells. The study, led by Judith Shizuru, MD, PhD, associate professor of medicine, will be published online Aug. 2 in the Proceedings of the National Academy of Sciences. Bone marrow transplantation has long been...

2010-06-11 13:13:06

Reprogramming immune system cells to produce natural killer cells for cancer A team of researchers has developed a method to produce cells that kill tumour cells in the lab and prevent tumours forming in mouse models of cancer. Although the current work is in cells and mouse, if the research transfers to human biology, the new type of cell could be a new source for cell-based anticancer therapies. The cells were produced by knocking out a single gene essential in the pathways of development...

2010-05-18 14:22:32

Technique provides great insight into immune response A commonly used probe for Positron Emission Tomography (PET) scanning and a new probe developed by researchers at UCLA reveal different functions in diverse cells of the immune system, providing a non-invasive and much clearer picture of an immune response in action. The probes, the commonly used FDG that measures cellular glucose metabolism, and FAC, developed at UCLA and which measures the activity of a distinct biochemical pathway, work...

2010-05-04 12:57:05

Discovery may lead to new treatments for leukemia and lymphoma New research has identified that a key protein called PEA-15 stops T-cell proliferation by blocking the cell's ability to reproduce. The control of T-cell proliferation is essential in preventing certain blood cancers and autoimmune diseases, as well as the orchestration of the immune response to infection. Findings of the study are reported in a recent online issue of The FASEB Journal, a publication of The Federation of American...

2010-03-22 08:08:00

New research may guide creation of targeted, more effective vaccines BOSTON, March 22 /PRNewswire-USNewswire/ -- A new understanding of a certain cell in the immune system may help guide scientists in creating better flu vaccines, report researchers from the Program in Cellular and Molecular Medicine and the Immune Disease Institute at Children's Hospital Boston (PCMM/IDI). Reporting online March 21 in Nature Immunology, they show, for the first time, that white blood cells known as...

2010-03-22 14:58:35

New research may guide creation of targeted, more effective vaccines A new understanding of a certain cell in the immune system may help guide scientists in creating better flu vaccines, report researchers from the Program in Cellular and Molecular Medicine and the Immune Disease Institute at Children's Hospital Boston (PCMM/IDI). Reporting online March 21 in Nature Immunology, they show, for the first time, that white blood cells known as resident dendritic cells (DCs) capture flu viruses...

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2010-03-08 06:50:00

As much as half the world's population has less than adequate immune systems where their killer T cells cannot fight infection properly, and scientists find that vitamin D is a vital key to keeping their defenses up. Danish researchers have found that vitamin D could help with the fight against infectious diseases and worldwide epidemics, and could be very useful in finding new vaccines, they said. The researchers found that T cells in people's immune systems rely on vitamin D to become...

2009-12-08 18:11:25

Innovative strategy could be effective against other chronic viral diseases Researchers from the UCLA AIDS Institute and colleagues have for the first time demonstrated that human blood stem cells can be engineered into cells that can target and kill HIV-infected cells "” a process that potentially could be used against a range of chronic viral diseases. The study, published Dec. 7 in the-peer reviewed online journal PLoS ONE, provides proof-of-principle "” that is, a...