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Latest Lymphocyte Stories

2009-12-02 10:17:20

The right kind of stress response in the operating room could lead to quicker recovery for patients after knee surgery, according to a new study led by Stanford University School of Medicine researchers. The results could be used to develop methods for predicting how well patients will fare after they leave the hospital. The study, conducted with colleagues at Yale University and to be published Dec. 1 in the Journal of Bone and Joint Surgery, found that patients whose immune systems...

2009-10-15 14:10:42

Fox Chase researchers uncover process that determines the fate of white blood cells Like an unusually forceful career counselor, the Id3 protein decides the fate of a given white blood cell precursor, according to researchers at Fox Chase Cancer Center. Their findings, published today in the journal Immunity, describe how Id3 directs blood cell progenitors to become gamma-delta T cells. Gamma-delta T cells are unique in that they possess attributes of both the adaptive arm of the immune...

2009-10-14 13:17:08

Specific cells within the immune system could help explain why younger people are more susceptible to variant CJD, scientists believe Specific cells within the immune system could help explain why younger people are more susceptible to variant CJD, scientists believe. Patients diagnosed with variant CJD are, on average, 28 years old but it has been unclear why older people are not as affected by the disease. Research at The Roslin Institute of the University of Edinburgh has identified...

2009-10-02 10:36:21

Researchers from Brown University and McGill University have discovered that the natural killer, or NK cells, help prevent T cells from over-responding when a virus hits. This balance helps prevent T cells, which ordinarily serve the immune system, from causing harm. Details are in the September issue of The Journal of Experimental Medicine. Natural killer, or NK cells, are part of our innate immune system. A healthy body produces them to respond early during infection. They are activated and...

2009-09-22 09:11:56

After more than 50 experiments in mice, medical scientists at Johns Hopkins have mapped out the basic steps taken by a particular set of white blood cells in setting the pace of recovery after serious lung injury. The white blood cells are called regulatory T cells, or Tregs for short, and their best known function is to keep the body's immune system from attacking its own healthy tissues. "Our study results are the critical first leads in finding treatments for a clinical condition that...

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2009-09-16 10:34:33

Disease mechanism in HIV infection decoded / Heidelberg virologists publish in "Cell Host & Microbe" In order to be able to ward off disease pathogens, immune cells must be mobile and be able to establish contact with each other. The working group around Professor Dr. Oliver Fackler in the Virology Department of the Hygiene Institute of the Heidelberg University Hospital has discovered a mechanism in an animal model revealing how HIV, the AIDS pathogen, cripples immune cells: Cell...

2009-09-15 08:01:30

X-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency most commonly caused by deficiency in the protein SAP. Following infection with the common virus that causes infectious mononucleosis (also known as mono or glandular fever), boys with XLP often develop an extreme, usually fatal, accumulation of activated immune cells known as cytotoxic T lymphocytes; but the mechanistic link between this and SAP deficiency has not been determined. However, Michael Lenardo and...

2009-08-06 13:33:11

 A team of researchers from The Wistar Institute has identified a protein that could serve as a target for reprogramming immune system cells exhausted by exposure to chronic viral infection into more effective "soldiers" against certain viruses like HIV, hepatitis C, and hepatitis B, as well as some cancers, such as melanoma.Effective response by key immune cells in the body, called T cells, is crucial for control of many widespread chronic viral infections such as HIV and hepatitis B...

2009-06-22 10:06:34

Rapamycin, a drug given to transplant recipients to suppress their immune systems, has a paradoxical effect on cells responsible for immune memory, scientists at the Emory Vaccine Center have discovered.In experiments conducted in both mice and monkeys, rapamycin can stimulate the formation of memory CD8 T cells, which enable the immune system to respond faster and stronger to an infectious agent upon a second encounter.The results were published online ahead of print June 21 in Nature. The...

2009-06-12 10:13:38

Copenhagen, Denmark, Friday 12 June 2009: First line treatment with anakinra (an interleukin-1 (IL-1) receptor antagonist), results in a 'good' clinical response (ACRp90) in patients newly diagnosed with systemic onset juvenile idiopathic arthritis (SoJIA), and restores the deficient IL-18 response of natural killer (NK) cells*, according to a new study presented today at PReS 2009, a joint congress with the 2009 Congress of the European League Against Rheumatism (EULAR) in Copenhagen,...