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Latest Macrolide antibiotics Stories

2011-08-09 08:07:07

Total joint replacement surgeries can help relieve joint pain common in people with conditions like osteoarthritis. But sometimes, the debris from prosthetic joints leads to aseptic loosening, or disintegration of surrounding bones. In 2009, a Wayne State University researcher determined that the anti-inflammatory antibiotic erythromycin can prevent and treat such disintegration. There was one caveat, however: there are side effects associated with long-term usage of erythromycin. But Weiping...

2011-04-07 07:00:00

CHAPEL HILL, N.C., April 7, 2011 /PRNewswire/ -- Cempra Pharmaceuticals Inc. today announced that Prabhavathi Fernandes, Ph.D., president and chief executive officer, will present at two upcoming CHI conferences. Dr. Fernandes will present at the Second Annual Anti-Inflammatories: Small Molecule Approaches Conference at 5 p.m. PDT, April 12, at the Hilton San Diego Resort in San Diego. Her presentation is entitled "Macrolides as a New Class of Orally Active Anti-Inflammatory Agents." Her...

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2011-01-18 13:15:00

According to a study published on Monday, older adults on blood pressure drugs known as calcium channel blockers could suffer dangerous drops in blood pressure if they are given certain antibiotics. Researchers found that patients on calcium channel blockers who were given the antibiotics erythromycin or clarithromycin were at an increased risk of being hospitalized for dangerously low blood pressure. A third antibiotic in the same class was not linked to the risk.  The researchers say...

2011-01-17 20:58:14

Mixing commonly used antibiotics with common blood pressure medications may cause hypotension (abnormally low blood pressure) and induce shock in older patients, requiring hospitalization, according to a study published in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj100702.pdf. "Macrolide antibiotics (erythromycin, clarithromycin and azithromycin) are among the most widely prescribed antibiotics, with millions of prescriptions dispensed...

2011-01-12 06:00:00

CHAPEL HILL, N.C., Jan. 12, 2011 /PRNewswire/ -- Cempra Pharmaceuticals presented the broad spectrum and potent activity profile of solithromycin (CEM-101), the first fluoroketolide antibiotic, at the 5th Annual PHEMCE stakeholders workshop and Biomedical Advanced Research and Development Authority (BARDA) industry day on January 10 to 12 in Washington D.C. Solithromycin is a clinical-stage fluoroketolide antibiotic with potent and broad-spectrum activity against gram-positive and...

2010-12-01 06:00:00

CHAPEL HILL, N.C., Dec. 1, 2010 /PRNewswire/ -- Cempra Pharmaceuticals and HiQScreen today announced the publication of research revealing the molecular mechanisms that could explain certain unique adverse events associated with the ketolide, telithromycin (Ketek(TM)), which led to its restricted use. The study also showed that Cempra's novel fluoroketolide, solithromycin (CEM-101) is unlikely to generate the adverse events seen with telithromycin. The report was published in the...

2010-11-24 11:42:38

Biosynthetic breakthrough paves way for other pharmaceuticals Researchers at Tufts University School of Engineering have reported the first successful production of the antibiotic erythromycin A, and two variations, using E. coli as the production host. The work, published in the November 24, 2010, issue of Chemistry and Biology, offers a more cost-effective way to make both erythromycin A and new drugs that will combat the growing incidence of antibiotic resistant pathogens. Equally...


Word of the Day
penuche
  • A fudgelike confection of brown sugar, cream or milk, and chopped nuts.
'Penuche' is a variant of 'panocha,' a coarse grade of sugar made in Mexico. 'Panocha' probably comes from the Spanish 'panoja, panocha,' ear of grain.
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