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Last updated on April 20, 2014 at 14:04 EDT

Latest Macrophages Stories

2013-12-11 12:57:14

They have discovered how the anti-tumor activity of immune cells can be restored The Leuven-based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth. They have also demonstrated that blocking the protein Nrp1 can restore this anti-tumor immune response. This is a first. Nrp1 may provide an important hub for the development of new therapies against cancer. Max Mazzone: "For many...

2013-11-25 16:39:32

A new kind of genetic switch can target the activities of just one type of brain cell Mysterious brain cells called microglia are starting to reveal their secrets thanks to research conducted at the Weizmann Institute of Science. Until recently, most of the glory in brain research went to neurons. For more than a century, these electrically excitable cells were believed to perform the entirety of the information processing that makes the brain such an amazing machine. In contrast, cells...

2013-11-15 10:58:29

Identifying 'sensome' of microglia could improve understanding, treatments for neurodegenerative disorders Massachusetts General Hospital (MGH) investigators have used a new sequencing method to identify a group of genes used by the brain's immune cells – called microglia – to sense pathogenic organisms, toxins or damaged cells that require their response. Identifying these genes should lead to better understanding of the role of microglia both in normal brains and in neurodegenerative...

2013-08-12 14:16:37

The growth of deadly plaque inside the walls of arteries may not happen as scientists believed, research from the University of Toronto and Massachusetts General Hospital has found. The research also suggests a new potential target in the treatment of atherosclerosis, a leading cause of cardiovascular disease and death globally. The research team found that macrophages, white blood cells that drive atherosclerosis, replicate inside plaques. Moreover, this growth is not reliant on cells...

2013-08-12 11:28:38

Proliferation of immune cells within plaques is key mechanism, potential treatment target New insights into the development of vulnerable atherosclerotic plaques could lead to better treatment or prevention of heart attacks and strokes. In a report being published online in Nature Medicine, researchers at the Massachusetts General Hospital (MGH) Center for Systems Biology re-evaluated previous assumptions regarding the role of inflammatory cells in atherosclerosis and found that the...

2013-06-14 12:27:42

-Alveolar macrophage (AM) function plays a critical role in protecting the lungs by removing particulates. -Chronic drinking causes persistent oxidative stress in the lungs, leading to impaired AM function. -A new rodent study shows that chronic drinking appears to intensify lung damage caused by particulate matter. Alveolar macrophage (AM) function plays a critical role in protecting the lungs from particulate matter inhalation by removing particulates from the airway and secreting...

Macrophages Key In Salamander Regeneration
2013-05-21 15:06:03

Brett Smith for redOrbit.com - Your Universe Online For years, scientists have considered salamanders the ℠Holy Grail´ of biological regeneration. Now, a new study in the Proceedings of the National Academy of Sciences has revealed an exciting step forward in the quest to adapt this ability for medical use in humans. Based on experiments with the tiny amphibians, researchers from the Australian Regenerative Medicine Institute at Monash University have found that elements of a...

2013-04-24 16:33:52

Researcher Johan Jakobsson and his colleagues have now published their results in Nature Communications "At present, researchers know very little about exactly how microglia work. At the same time, there is a lot of curiosity and high hopes among brain researchers that greater understanding of microglia could lead to entirely new drug development strategies for various brain diseases", says Johan Jakobsson, research group leader at the Division of Molecular Neurogenetics at Lund...

Silent Watchmen Attack To Defend The Nervous System
2012-10-16 17:20:26

In many pathologies of the nervous system, there is a common event - cells called microglia are activated from surveillant watchmen into fighters. Microglia are the immune cells of the nervous system, ingesting and destroying pathogens and damaged nerve cells. Until now little was known about the molecular mechanisms of microglia activation despite this being a critical process in the body. Now new research from the Montreal Neurological Institute and Hospital — The Neuro - at McGill...

Immune System Can Accelerate Regeneration Of Peripheral Nerves
2012-10-02 13:19:21

Finding the 'master knob to turn on nerve repair' Modulating immune response to injury could accelerate the regeneration of severed peripheral nerves, a new study in an animal model has found. By altering activity of the macrophage cells that respond to injuries, researchers dramatically increased the rate at which nerve processes regrew. Influencing the macrophages immediately after injury may affect the whole cascade of biochemical events that occurs after nerve damage, potentially...