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Latest Macrophages Stories

2013-04-24 16:33:52

Researcher Johan Jakobsson and his colleagues have now published their results in Nature Communications "At present, researchers know very little about exactly how microglia work. At the same time, there is a lot of curiosity and high hopes among brain researchers that greater understanding of microglia could lead to entirely new drug development strategies for various brain diseases", says Johan Jakobsson, research group leader at the Division of Molecular Neurogenetics at Lund...

Silent Watchmen Attack To Defend The Nervous System
2012-10-16 17:20:26

In many pathologies of the nervous system, there is a common event - cells called microglia are activated from surveillant watchmen into fighters. Microglia are the immune cells of the nervous system, ingesting and destroying pathogens and damaged nerve cells. Until now little was known about the molecular mechanisms of microglia activation despite this being a critical process in the body. Now new research from the Montreal Neurological Institute and Hospital — The Neuro - at McGill...

Immune System Can Accelerate Regeneration Of Peripheral Nerves
2012-10-02 13:19:21

Finding the 'master knob to turn on nerve repair' Modulating immune response to injury could accelerate the regeneration of severed peripheral nerves, a new study in an animal model has found. By altering activity of the macrophage cells that respond to injuries, researchers dramatically increased the rate at which nerve processes regrew. Influencing the macrophages immediately after injury may affect the whole cascade of biochemical events that occurs after nerve damage, potentially...

2012-05-24 21:21:45

How the brain's emergency workers find the disaster area Like emergency workers rushing to a disaster scene, cells called microglia speed to places where the brain has been injured, to contain the damage by 'eating up' any cellular debris and dead or dying neurons. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have now discovered exactly how microglia detect the site of injury, thanks to a relay of molecular signals. Their work, published today in...

2012-05-02 20:14:36

Macrophages play a key role in the immune response, protecting organisms against infection and regulating the development of inflammation in tissue. Macrophages differ depending on where they are located and which tasks they perform. A scientist at TUM has been investigating whether these different types of cells have the same origin — and has come up with some surprising results. His findings reveal that there are two distinct macrophage cell lines that continue into adult life and...

2012-04-11 22:29:29

The theory that pigeons' famous skill at navigation is down to iron-rich nerve cells in their beaks has been disproved by a new study published in Nature. The study shows that iron-rich cells in the pigeon beak are in fact specialized white blood cells, called macrophages. This finding, which shatters the established dogma, puts the field back on course as the search for magnetic cells continues. "The mystery of how animals detect magnetic fields has just got more mysterious" said Dr...

2012-03-19 10:15:44

Microglia are the first line defence of the brain and are constantly looking for infections to fight off. Overactive microglia can cause uncontrolled inflammation within the brain, which can in turn lead to neuronal damage. New research published in BioMed Central's open access journal Journal of Neuroinflammation shows that, honokiol (HNK) is able to down-regulate the production of pro-inflammatory cytokines and inflammatory enzymes in activated microglia via Klf4, a protein known to...

2012-02-22 21:34:08

Sometimes our immune defence attacks our own cells. When this happens in the brain we see neurodegenerative diseases such as dementia, Alzheimer´s and Parkinson´s disease. But if the the immune defence is inhibited, the results could be disastrous. Researchers at the University of Copenhagen have now discovered one of the molecular combat mechanisms in the brain that gets out of control in these diseases. In time this may enable targeted therapies to slow down the disease without...

2012-02-02 22:41:13

Scientists at the University Medical Center in Mainz prove multiple DNA repair defect in monocytes Scientists working with Professor Bernd Kaina of the Institute of Toxicology at the Medical Center of Johannes Gutenberg University Mainz have demonstrated for the first time that certain cells circulating in human blood — so-called monocytes — are extremely sensitive to reactive oxygen species (ROS). They were also able to clarify the reason for this: ROS are aggressive forms of...


Word of the Day
ramage
  • Boughs or branches.
  • Warbling of birds in trees.
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