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Latest Macrophages Stories

2010-10-27 14:42:55

Scientist also successfully visualises, in a living cell culture, how the immune cells colonise the brain Findings could lead to new strategies to treat various brain disorders 1. A team of international scientists led by Dr Florent Ginhoux of the Singapore Immunology Network (SIgN) of Singapore's Agency of Science, Technology and Research (A*STAR), have made a breakthrough that could lead to a better understanding of many neurodegenerative and inflammatory brain disorders. Their work,...

2010-10-23 01:38:12

Mount Sinai researchers have discovered that microglia, the immune cells that reside in the brain, have a unique origin and are formed shortly after conception. It was previously thought that microglia originated at the same time as macrophages, which are other immune cells that are thought to develop at birth. This groundbreaking discovery has the potential to lead to future treatments of degenerative brain diseases such as Alzheimer's and autoimmune diseases such as multiple sclerosis. The...

2010-10-13 14:49:01

A diet rich in the plant compound luteolin reduces age-related inflammation in the brain and related memory deficits by directly inhibiting the release of inflammatory molecules in the brain, researchers report. Luteolin (LOOT-ee-oh-lin) is found in many plants, including carrots, peppers, celery, olive oil, peppermint, rosemary and chamomile. The new study, which examined the effects of dietary luteolin in a mouse model of aging, appears in the Journal of Nutrition. The researchers focused...

2010-10-07 13:32:40

Cells that help to protect the central nervous system may also contribute to pathological changes in the brain. New research, published by Cell Press in the October 7th issue of the journal Neuron, provides mechanistic insight into a link between the immune system and neurodegenerative disorders like Alzheimer's disease that are associated with abnormal accumulation of tau protein. Tau is a protein found inside of neurons that acts almost like a skeleton, providing a supportive framework for...

2010-07-29 15:28:20

Researcher discovers existing drugs can potentially target the disease's ability to spread Often causing no symptoms in carriers of the disease, worldwide tuberculosis (TB) infects eight to ten million people every year, kills two million, and it is highly contagious as it is spread through coughing and sneezing. "It's a global health disaster waiting to happen, even here in Canada, but this new paradigm in TB research may offer an immediate opportunity to improve vaccination and treatment...

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2010-05-28 07:38:18

Bone-marrow transplants cure mice of hair-pulling compulsion A Nobel Prize-winning University of Utah geneticist discovered that bone marrow transplants cure mutant mice who pull out their hair compulsively. The study provides the first cause-and-effect link between immune system cells and mental illness, and points toward eventual new psychiatric treatments. "We're showing there is a direct relationship between a psychiatric disorder and the immune system, specifically cells named microglia...

2010-05-27 16:55:51

Scientists earlier found that mice missing one of a group of core developmental genes known as the Hox genes developed an odd and rather unexpected pathology: the mutant animals groomed themselves compulsively to the point that they were removing their own hair and leaving self-inflicted open sores on their skin. Now, they've found a surprising connection between the Hoxb8 gene and the behavior that looks an awful lot like that of people with an obsessive compulsive spectrum disorder (OCD)....

2010-03-22 14:45:03

Microglia are the cells responsible for immune surveillance in the brain, and they initiate protective inflammatory reactions in response to tissue damage and infection. An international team under the leadership of LMU neuroscientist Professor Jochen Herms has now shown that these cells may actually make a significant contribution to the loss of neurons associated with Alzheimer's disease. About 1.2 million people are thought to suffer from this form of progressive dementia in Germany, and...

2010-03-03 13:21:51

The signaling molecule CD95L, known as "death messenger," causes an inflammatory process in injured tissue after spinal cord injuries and prevents its healing. This discovery was published by scientists of the German Cancer Research Center. In mice, the researchers found out that if they switch off CD95L, the injured spinal cord heals and the animals regain better ability to move. Therefore, substances which block the death messenger might offer a new approach in the treatment of severe...

2010-03-01 10:31:30

New research published in the Journal of Leukocyte Biology suggests that simvastatin negatively impacts the immune system's ability to clear infection and control inflammation in the presence of bacteria Simvastatin might help us control our cholesterol, but when it comes to infection, it's an entirely different story says a new research study published in the Journal of Leukocyte Biology (http://www.jleukbio.org). In the research report, scientists from Italy show that simvastatin delivers a...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'