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Latest Major histocompatibility complex Stories

2012-01-10 23:20:43

The cocktail maintaining immune gene variation The great variation of a specific form of immune genes makes organ transplants so complicated. On the other hand, we need such a great variability in order to resist infectious diseases. This is why it also plays a major role in the selection of sexual partners. Up until now, the mechanisms for maintaining this standing genetic variation have remained an evolutionary puzzle. In a study of sticklebacks, researchers from the Max Planck Institute...

2011-11-28 17:28:53

Roche NimbleGen, Inc. and BGI, the world's largest genomics organization, announced that they have developed a Major Histocompatibility Complex (MHC) region capture technology based on NimbleGen SeqCap EZ Choice Library, a revolutionary process for the enrichment of the MHC region. This newly developed approach allows easy capture and enrichment of these highly repetitive regions and enables the generation of deep sequencing coverage of the human MHC region. This new sample preparation...

2011-10-11 20:20:20

The research shows that in addition to the major histocompatibility complex (MHC) molecules, which present the antigen vaccine to the immune cells, genetic factors, that control some immune cells, influence the quality of response to vaccinations. The results could make it possible to prevent neuroinflammatory reactions, which are major obstacles preventing the use of the vaccination in humans. This study has just been published in the Journal of Immunology. Since the beginning of the 2000s,...

2011-10-03 12:30:51

A central element of the immune system has remained constant through more than 400 million years of evolution, according to new research at National Jewish Health. In the September 29, 2011, online version of the journal Immunity, the researchers report that T-cell receptors from mice continue to function even when pieces of shark, frog and trout receptors are substituted in. The function of the chimeric receptors depends on a few crucial amino acids, found also in humans, that help the...

2011-08-30 11:15:03

Bleeding calf syndrome (bovine neonatal pancytopenia or BNP) affects new born calves resulting in low blood cell counts and depletion of the bone marrow. It first emerged in 2007 and a serious number of cases are reported each year. In affected calves, bone marrow cells which produce platelets are also destroyed. Consequently the calves' blood does not clot and they appear to bleed through undamaged skin. There is evidence that BNP is linked to the use of a particular vaccine against "Bovine...

2011-06-24 12:08:30

The ability to identify self and non-self enables cells in more sophisticated animals to ward off invading infections, but it is critical to even simpler organisms such as the social amoebae Dictyostelium discoideum. Dictyostelium exists as a single cell when times are good, but when starved, the cells aggregate and become multi-cellular fruiting bodies with a dead stalk and live spores that allow the cells to survive and pass on genes. When the social amoeba aggregates, it prefers to do so...

2011-06-23 22:54:06

The ability to identify self and non-self enables cells in more sophisticated animals to ward off invading infections, but it is critical to even simpler organisms such as the social amoebae Dictyostelium discoideum. Dictyostelium exists as a single cell when times are good, but when starved, the cells aggregate and become multi-cellular fruiting bodies with a dead stalk and live spores that allow the cells to survive and pass on genes. When the social amoeba aggregates, it prefers to do so...

2011-05-27 13:37:04

How females select their sexual partners is a matter of more than passing concern to a large number of males.  Focus has gradually switched from the idea that certain males are the most attractive or the best and researchers are increasingly considering the idea that particular individuals might be intrinsically compatible.  Dating agencies routinely include questions about potential partners' hobbies and interests.  Such issues are clearly important but the latest results from...

2011-02-28 13:47:34

The number of connections between nerve cells in the brain can be regulated by an immune system molecule, according to a new study from UC Davis. The research, published Feb. 27 in the journal Nature Neuroscience, reveals a potential link between immunity, infectious disease and conditions such as schizophrenia or autism. Schizophrenia, autism and other disorders are associated with changes in connectivity in the brain, said Kimberley McAllister, associate professor in the Center for...


Word of the Day
Cthulhu
  • A gigantic fictional humanoid alien god being described with a head resembling an octopus and dragon wings and claws, around whom an insane cult developed.
  • Pertaining to the mythos of Cthulhu and additional otherworldly beings created by H. P. Lovecraft or inspired by his writings and imitators.
This word was invented in 1926 by H.P. Lovecraft for his short story, 'The Call of Cthulhu.' 'Cthulhu' may be based on the word 'chthonic,' which in Greek mythology refers to the underworld.
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