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Latest Major histocompatibility complex Stories

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2011-01-20 11:40:00

Researchers have for the first time mapped the complex choreography used by the immune system's T cells to recognize pathogens while avoiding attacks on the body's own cells. The researchers found that T cell receptors "“ molecules located on the surface of the T cell "“ first bind with the antigen on the pathogen-invaded cell. That initiates a signaling process which leads a co-receptor on the T cell to also bind with the molecule that presents the antigen, amplifying the effect....

2011-01-06 09:37:21

(Ivanhoe Newswire) -- Women who have multiple sclerosis (MS) are more likely to have the gene associated with MS than men with the disease, according to a new study. Previous studies show that the number of people diagnosed with MS is on the rise, and the rate is growing more rapidly for women. There is no known cause for MS, but evidence suggests that it is triggered by environmental factors in people who are genetically susceptible to the disease. The main gene associated with MS in the...

2010-11-22 19:29:39

Since 1871, when Charles Darwin wrote The Descent of Man, it has been widely accepted that "Variability is the necessary basis for the action of selection." Variability is associated with the ability to adapt, which is clearly beneficial at a species level. But there is increasing evidence that genetic variability may also give rise to advantages at the level of the individual. Steve Smith and Franz Suchentrunk at the Research Institute of Wildlife Ecology, University of Veterinary Medicine,...

2010-11-01 15:12:07

New approach could speed better tests for earliest appearance of cancer cells and help develop vaccines Scientists at Johns Hopkins have taken a less-is-more approach to designing effective drug treatments that are precisely tailored to disease-causing pathogens, such as viruses and bacteria, and cancer cells, any of which can trigger the body's immune system defenses. In a report to be published in the latest issue of Nature Medicine online Oct. 31, researchers describe a new...

2010-10-14 13:58:29

Finding may shed light on roots of schizophrenia, autism UCLA scientists have discovered that exposing fetal neurons to higher than normal levels of a common immune protein leads to abnormal brain development in mice. Published Oct. 14 in the online Journal of Neuroimmunology, the finding may provide new insights into factors contributing to human neurological disorders like schizophrenia and autism. The researchers studied a protein called major histocompatibility complex, or MHC. The...

2010-07-28 14:17:00

University of East Anglia research shows birds may increase their offspring's survival through infidelity Why does female infidelity occur so frequently throughout the animal kingdom? A 10-year study from the University of East Anglia published today shows that female birds may increase their offspring's survival through their infidelity. Although in many animals females may pair up with a specific 'social' mate who helps raise the pairs' offspring, DNA fingerprinting studies across a wide...

2010-07-13 15:19:48

Researchers with the National Institutes of Health have found susceptibility to Behcet's disease, a painful, inflammatory condition, to be associated with genes involved in the body's immune response. Although the Greek physician Hippocrates described Behcet's disease (pronounced BET'-chet's), more than 2,000 years ago, the condition existed in relative obscurity until the early 20th century. Named for the Turkish physician who first classified it in 1937, Behcet's disease is found almost...

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2010-03-31 14:27:54

T cell receptors are among the most important molecules in the immune system because of their role in recognizing the antigens that signal such threats as viruses and cancer. The receptors must also distinguish these threats from the body's own cells to avoid triggering an unwanted immune system response. Recognition requires direct physical contact between the receptor and the antigen. Researchers attempting to understand this critical mechanism, therefore, have been studying such factors as...

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2009-11-25 09:20:10

The world's largest species of monkey 'chooses' mates with genes that are different from their own to guarantee healthy and strong offspring, according to a new research study. The results obtained from mandrills, a species closely related to humans, support the disputed theory that humans are attracted to those with a dissimilar genetic make up to maintain genetic diversity. Female mandrills are more likely to reproduce with males whose genes are complementary, possibly because they 'smell...

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2009-11-03 07:39:54

May lead to more effective, precisely targeted therapies for cancers and infections The immune system's T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery. In a new study, investigators at Dana-Farber Cancer Institute, Harvard Medical School,...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.