Latest Malaria Venture Stories

Drug may be major advance as malaria has developed resistance to existing treatments Scientists at Oregon Health & Science University and the Portland VA Medical Center have developed a drug that may represent one of the world's best hopes for treating and preventing malaria — a disease that kills more than one million people each year. The scientists have described the drug, and its effectiveness against mice infected with malaria, in the March 20 issue of Science Translational...

Medicines for Malaria Venture has developed a framework to evaluate the risk of resistance for the antimalarial compounds in its portfolio. A paper based on this work: A framework for assessing the risk of resistance for antimalarials in development has been published in the Malaria Journal today. Resistance defines the longevity of every anti-infective drug, so it is important when developing new medicines for malaria, to check how easily promising antimalarial compounds will select for...

Data publicly available for global discovery The discovery of a new class of dual-acting antimalarial compounds - the imidazolopiperazines (IZPs) – was published in the journal Science online, at the Science Express website today1. The findings report on compounds that target both liver and blood infections, attacking the Plasmodium parasite at both stages in its reproduction cycle. The findings describe how scientists developed a novel assay to determine liver stage activity of...

--WIPO Re:Search, A New Consortium of Public and Private Sector Organizations, Drives Research and Development Partnerships with Neglected Tropical Disease Researchers-- Geneva press conference to launch WIPO Re:Search on October 26, 2011 at 10:30 CEST will be webcast live http://www.bvgh.org/WIPO-ReSearch-Webcast.aspx GENEVA, Oct. 26, 2011 /PRNewswire-USNewswire/ -- The World Intellectual Property Organization (WIPO), in an unprecedented collaboration with leading pharmaceutical companies...

NIH researchers show parasites create feeding ion channels in blood cellsSnug inside a human red blood cell, the malaria parasite hides from the immune system and fuels its growth by digesting hemoglobin, the cell's main protein. The parasite, however, must obtain additional nutrients from the bloodstream via tiny pores in the cell membrane. Now, investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have found the...

A drug-resistant strain of malaria could spread from southeast Asia to Africa in as little as three months, which puts millions of children at risk, according to a warning from a leading expert Wednesday. Nicholas White, professor of tropical medicine at Mahidol University in Bangkok, said its time to bring a war against malaria before it is too late. The new strain is resistant to the drug artemisinin that was first used along the Thai-Cambodian border in 2007. The new longer-to-treat form...

New antimalarial drug candidate with novel mechanism of action has the potential to rapidly clear a Plasmodium infection upon administration of a single oral dose, as published in ScienceNovartis announced today that scientists at the Novartis Institute for Tropical Diseases (NITD), in collaboration with researchers from the Genomics Institute of the Novartis Research Foundation (GNF), the Swiss Tropical and Public Health Institute and The Scripps Research Institute have discovered a novel...

As part of a multicenter study, UT Southwestern Medical Center researchers have identified a series of chemical compounds that might serve as starting points for the identification of new classes of anti-malarial drugs."Malaria remains one of the most globally significant infectious diseases that we face," said Dr. Margaret Phillips, professor of pharmacology at UT Southwestern and one of the senior authors of the study, which appeared in the May 20 issue of Nature. Malaria affects about 40...

International collaboration led by St. Jude Children's Research Hospital scientists identifies promising compounds for anti-malarial drug development and launches a database to share findings, advance fight against a leading killer of the world's childrenAn international team led by St. Jude Children's Research Hospital investigators today released data detailing the effectiveness of nearly 310,000 chemicals against a malaria parasite that remains one of the world's leading killers of young...

MEMPHIS, Tenn., May 19 /PRNewswire/ -- An international team led by St. Jude Children's Research Hospital investigators today released data detailing the effectiveness of nearly 310,000 chemicals against a malaria parasite that remains one of the world's leading killers of young children. To view the multimedia assets associated with this release, please click: http://multivu.prnewswire.com/mnr/stjude/44038/ The research, which appears in the May 20 edition of the scientific journal Nature,...