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Latest Manel Esteller Stories

2014-04-10 14:53:02

In 10% of human tumors there is a family history of hereditary disease associated with mutations in identified genes. The best examples are the cases of polyps in the large intestine associated with the APC gene and breast cancer associated with BRCA1 and BRCA2 genes. In the remaining 90% of cases are believed to have an increased risk of developing cancer in relation to genetic variants less powerful but more often, for example, doubles the risk of having a tumor that lacks this small...

2014-01-22 10:56:45

Alzheimer's disease can reach epidemic range in the coming decades, by the increasing average age of society.There are two key issues for Alzheimer's disease: there is currently no effective treatment and it has been described very few associated genetic changes (mutations) which reduces the number of targets for future therapies. Alzheimer's disease Pathologically, Alzheimer's disease is characterized by the accumulation of protein deposits in the brain of patients. These deposits are...

2012-10-17 11:51:53

It can be detected an epigenetic alteration associated with an increased risk of breast cancer in the sick twin a few years before the clinical diagnosis Monozygotic twins have the same genome, that is, the same DNA molecule in both siblings. Despite being genetically identical, both twins may have different diseases at different times. This phenomenon is called "twin discordance". But how can people who have the same genetic sequence present different pathologies and at different ages?...

2012-03-06 11:05:26

Discovered a mechanism explaining how tumor cells spread to nearby organs and structures, initiating metastasis Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the mechanisms responsible for this process is one of the top goals of cancer research. The metastatic process involves a series of steps chained where the primary tumour invades surrounding tissues and ends spreading throughout the body. Ones of the first tissues undergoing metastasis are the...

2011-11-09 16:07:51

Patients with recurrent metastatic non-small cell lung cancer have a morbid prognosis, but a new epigenetic therapy may have potential in this population, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research. A research team at Johns Hopkins University tested a combination epigenetic therapy of azacitidine and entinostat among patients with recurrent metastatic non-small cell lung cancer who had been heavily pretreated but showed no...

2011-06-02 13:39:37

The study may allow finding the unknown origin of metastasis and improving treatments Until a decade, it was believed that differences between people were due solely to the existence of genetic changes, which are alterations in the sequence of our genes. The discoveries made during these last ten years show that beings with the same genetics like the twins and cloned animals may have different characteristics and disease due to epigenetic changes. Epigenetics involves chemical signatures that...

2009-02-12 10:05:21

Scientists are on the path to figuring out why some viruses thrive in the human body. They mapped a chemical modification of DNA in three oncogenic viruses, Epstein-Barr, Human Papilloma Virus and Hepatitis B. They discovered the viral genome undergoes critical changes during the progression of disease, modifying its appearance in a way that camouflages DNA from the immune system. "This is a very exciting result that can explain why some of these viruses can survive such prolonged times in...

2009-02-10 10:07:15

An estimated 15% of cancer cases can be linked to a viral infection, however the biological changes that cause some asymptomatic carriers of a virus to develop full-blown tumors are not well understood. In a study published online in Genome Research, scientists have mapped a chemical modification of DNA in three oncogenic viruses (Epstein-Barr, human papilloma virus, and hepatitis B virus) and found that the viral genome undergoes critical changes during the progression of disease, with...

2005-07-07 18:15:00

COLUMBUS , Ohio "“ Identical twins lose some fundamental similarities as they grow older, a new study reports. They may start to look and act less alike. The changes could leave one twin susceptible to diseases like cancer, while the other twin remains healthy. Researchers report in this week's Proceedings of the National Academy of Sciences that these differences may stem from changes in the epigenome. The epigenome refers to chemical modifications in genes that don't directly affect...

2005-07-05 17:09:32

WASHINGTON (Reuters) - Identical twins grow apart,genetically, as the years pass, a team of European and U.S.researchers reported on Tuesday. Their study of identical twins show the genetic code itselfdoes not change, but rather chemical changes after birth alterthe way the gene is expressed, a process known as epigenetics. The study, which involved researchers and twins in Spain,Denmark, Britain, Sweden and the United States, can help shedlight on how environment and genes interact to...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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