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Although schizophrenia is highly genetic in origin, the genes involved in the disorder have been difficult to identify.
A rare â€œde novoâ€ protein-altering mutations- genetic errors that are present in patients but not in their parents- play a role in more than 50 percent of â€œsporadicâ€, not hereditary, cases of schizophrenia.
Columbia University Medical Center researchers have shown that new, or "de novo," protein-altering mutationsâ€”genetic errors that are present in patients but not in their parentsâ€”play a role in more than 50 percent of "sporadic" â€”i.e., not hereditaryâ€”cases of schizophrenia.
In what may provide the most compelling evidence to date, researchers at Columbia University Medical Center have illuminated how a genetic variant may lead to schizophrenia by causing a disruption in communication between the hippocampus and prefrontal cortex regions of the brain, areas believed to be responsible for carrying out working memory.
- A person or thing gazed at with wonder or curiosity, especially of a scornful kind.