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Latest Matrix metalloproteinase Stories

2013-10-31 10:34:32

University of Notre Dame researchers have, for the first time, identified the enzymes that are detrimental to diabetic wound healing and those that are beneficial to repair the wound. There are currently no therapeutics for diabetic wound healing. The current standard of care is palliative to keep the wound clean and free of infection. In the United States, 66,000 diabetic individuals each year undergo lower-limb amputations due to wounds that failed to heal. A team of researchers from...

2013-05-24 13:51:24

UEA scientists make breast cancer advance that turns previous thinking on its head Scientists at the University of East Anglia have made an advance in breast cancer research which shows how some enzymes released by cancerous cells could have a protective function. New research published today in the Journal of Biological Chemistry reveals that an enzyme called MMP-8 (matrix metalloproteinase-8) could be acting as a locator to the immune system, which then becomes activated to attack...

2012-06-11 19:05:16

Findings show new therapy has potential to help the brain as it reacts to stroke's harmful effects Researchers at the University of Missouri have demonstrated the effectiveness of a potential new therapy for stroke patients in an article published in the journal Molecular Neurodegeneration. Created to target a specific enzyme known to affect important brain functions, the new compound being studied at MU is designed to stop the spread of brain bleeds and protect brain cells from further...

2012-03-05 11:56:06

The University of Notre Dame's annual Bengal Bouts student boxing tournament's longtime mantra is "Strong Bodies Fight that Weak Bodies May Be Nourished." The unusual mantra is fitting for an unusual competition whose ticket sales proceeds benefit Holy Cross Missions in Bangladesh, part of the ministry of the Congregation for the Holy Cross, Notre Dame's founding religious community. However, this year a large number of Bengal Bouts boxers are going even further to do good by...

2011-12-26 07:23:28

A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine. Prof. Irit Sagi of the Biological Regulation Department and her...

2011-09-19 21:10:21

Water acts as an 'adhesive' in biological enzyme substrate compounds In biologically active enzyme substrate compounds, as can be found in medicines, water plays a more decisive role than has been imagined up to now. The surrounding water acts like an "adhesive", in order to keep the substrate at the right place on an enzyme. For this, the dynamism of the water is retarded. Scientists at the RUB under Prof. Dr. Martina Havenith (Physical Chemistry) in close cooperation with the group of...

2010-08-02 15:26:00

GPC3 is a member of the glypican family of glycosylphosphatidylinositol-anchored cell-surface heparan sulfate proteoglycans. GPC3 is highly expressed in HCC cells and tissues. It is thought that GPC3 joins a multiprotein complex, which is composed of the ligand, receptor, GPC3, and probably other proteins. However, little is known about the association of GPC3 expression with Wnt and other growth signaling molecules. Characterization of the association is necessary to better understand the...

2010-06-30 13:48:56

Study shows excess oxygen lessens impact of UVB radiation It's no secret that UVB radiation from the sun causes wrinkles. However, a Japanese study published in the American Journal of Physiology"”Regulatory, Integrative and Comparative Physiology indicates that oxygen may help combat the formation of wrinkles by lessening tissue damage done by UVB rays. In the study, mice who were placed in an oxygen chamber after exposure to UVB radiation developed fewer wrinkles and showed fewer...

2010-04-08 12:52:26

Gastric cancer in Mexico is the most frequent gastrointestinal malignant neoplasm. Several precursor conditions, such as chronic gastritis, have been associated with the development of gastric cancer. The gelatinases MMP-2 and MMP-9, members of the metalloproteinase family, are fundamental enzymes in extracellular matrix remodeling. The extracellular matrix is composed of secreted molecules outside cells which provides structural support and regulates cell behavior. The matrix...

2009-12-08 09:00:00

WALNUT CREEK, Calif., Dec. 8 /PRNewswire/ -- The National Fragile X Foundation has awarded a translational research seed grant of $100,000 to Dr. Randi J. Hagerman at the UC Davis M.I.N.D. Institute in California for a study of minocycline in the treatment of children with fragile X syndrome (FXS). Hagerman is an internationally recognized clinician and clinical researcher on FXS, the most common cause of inherited mental impairment. The two-year study will evaluate the efficacy of...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
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