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Latest Max Delbrück Center for Molecular Medicine Stories

2013-05-28 21:38:10

Cells have a sophisticated system to control and dispose of defective, superfluous proteins and thus to prevent damage to the body. Dr. Katrin Bagola and Professor Thomas Sommer of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch as well as Professor Michael Glickman and Professor Aaron Ciechanover of Technion, the Technical University of Israel in Haifa, have now discovered a new function of an enzyme that is involved in this vital process. Using yeast cells as...

2012-09-24 15:22:35

Germinal centers are sites in the organs of the lymphatic system, formed during the course of an immune response to infection, where B cells intensely proliferate and modify their DNA in order to produce antibodies specific for the pathogen. However, it is known that the vast majority of lymphomas derive from the B cells at the germinal centers. Now, Dr. Dinis Pedro Calado and Dr. Klaus Rajewsky of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have identified...

2012-09-10 11:01:08

Many patients with hypertension are treated with ACE inhibitors. These drugs block the angiotensin converting enzyme (ACE) that regulates the salt and water balance of the body and raises blood pressure. Recent studies by a research team led by Professor Ken Bernstein (Cedars-Sinai Medical Center, Los Angeles, California, USA) have, however, significantly broadened the enzyme´s known task spectrum: The enzyme also plays a key role in blood formation, renal development and male fertility....

2012-09-10 10:59:40

High blood pressure is responsible for many cardiovascular diseases that are the leading cause of death in industrialized countries. High salt intake has long been considered a risk factor, but not every type of high blood pressure is associated with high salt intake. This has puzzled scientists for a long time. However, new findings by Professor Jens Titze (Vanderbilt University, Nashville, Tennessee, USA and the University of Erlangen) now point to previously unknown mechanisms....

2012-08-04 02:09:56

Acute liver failure is a life-threatening disease, characterized by a sudden, massive death of liver cells. Unfortunately, few treatment options exist, especially for advanced-stage liver failure. As a last resort a liver transplant may be the only remaining option. Now the physician Dr. Junfeng An of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Dr. Stefan Donath, a specialist in internal medicine and cardiology, also of the MDC and Helios Klinikum...

2012-07-23 20:51:47

MDC and Charite researchers decipher the mechanism of action Neural precursor cells (NPC) in the young brain suppress certain brain tumors such as high-grade gliomas, especially glioblastoma (GBM), which are among the most common and most aggressive tumors. Now researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité — Universitätsmedizin Berlin have deciphered the underlying mechanism of action with which...

Ion Channel Makes African Naked Mole-Rat Insensitive To Acid-Induced Pain
2011-12-21 04:54:27

Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have found out why the African naked mole-rat (Heterocephalus glaber), one of the world´s most unusual mammals, feels no pain when exposed to acid. African naked mole-rats live densely packed in narrow dark burrows where ambient carbon dioxide (CO2) levels are very high. In body tissues, CO2 is converted into acid, which continuously activates pain sensors. However, naked mole-rats are an...

2011-02-16 15:41:59

Ebstein's anomaly is a rare congenital valvular heart disease. Now, in patients with this disease, researchers of the Academic Medical Center Amsterdam in the Netherlands, the University of Newcastle, UK and the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch have identified mutations in a gene which plays an important role in the structure of the heart. The researchers hope that these findings will lead to faster diagnosis and novel, more specifically targeted treatment methods...

2010-07-06 13:55:24

In their latest research, scientists of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have demonstrated how the brain's own stem cells and precursor cells control the growth of glioblastomas. Of all brain tumors, glioblastomas are among the most common and most aggressive. Dr. Sridhar Reddy Chirasani, Professor Helmut Kettenmann and Dr. Rainer Glass (all MDC) and Dr. Michael Synowitz (Charit© "“ Universitätsmedizin Berlin) have now shown in cell...

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2010-04-29 08:23:32

Researchers in Freiburg and Berlin unravel secret of innate immune response When the human body becomes infected with new influenza viruses, the immune system rapidly activates an inborn protective mechanism to inhibit the intruding pathogen. A protein known as Mx plays an important role in this process, keeping the spread of viruses in check. Exactly how Mx accomplishes this task was previously unknown. Now virologists from the Institute of Medical Microbiology at the Freiburg University...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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