Latest Mdm2 Stories
UC Davis researchers have uncovered a complex interaction between the proteins Rbm38 and p53 that governs tumor suppression and aging Sacramento, Calif.
Scientists armed with a supercomputer and a vast trove of newly collected data on the body’s most potent “tumor suppressor” gene have created the best map yet of how the gene works, an accomplishment
Cancer cells have long been known to have higher rates of the energy-generating metabolic pathway known as glycolysis.
According to a new study published in the Journal of Clinical Investigation, medical researchers at the University of North Carolina are developing a promising new treatment for macular degeneration.
A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death.
Cancer cells are a problem for the body because they multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don't belong.
It is perhaps impossible to overstate the importance of the tumor suppressor gene p53.
Cylene Pharmaceuticals today announced that research collaborators at the Peter MacCallum Cancer Centre (Peter Mac) in Melbourne, Australia have established, for the first time, that RNA Polymerase I (Pol I) activity is essential for cancer cell survival and that its inhibition selectively activates p53 to kill tumors.
Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective.
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