Latest Mdm2 Stories
Kaposi's sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi's sarcoma and primary effusion lymphoma (PEL).
Yale researchers have discovered how the "guardian of the genome'' oversees quality control in the production of sperm — and perhaps in many other cells as well.
The expression of p53 and Mdm2 is closely related. In an article published this week in the Cancel Cell review, Robin Fahraeus and his collaborators from Inserm Unit 940 ("Therapeutic Targets for Cancer"), demonstrate that cellular response to DNA damage requires involvement from the protein kinase ATM so that Mdm2 can positively or negatively control protein p53.
Researchers at the University of Southern California have identified two molecules that may be more effective cancer killers than are currently available on the market.
A protein that appears to play a key role in the formation of lymphoma and other tumors by inhibiting a tumor-suppressing gene has been identified by a team of veterinary and human medicine researchers at the University of California, Davis.
According to the Leukemia and Lymphoma Society, over 21,000 Americans died from lymphoma cancer last year.
Scientists at the Salk Institute for Biological Studies have found clues to the functioning of an important damage response protein in cells.
Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, p53.
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