Latest Mdm2 Stories
A study led by researchers at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.
Protein aggregation, generally associated with Alzheimerâ€™s and mad cow disease, turns out to play a significant role in cancer.
The gene for the protein p53 is the most frequently mutated in human cancer.
Like a bounty hunter returning escapees to custody, a cancer-fighting gene converts organ cells that change into highly mobile stem cells back to their original, stationary state.
Chemotherapeutic agents, used in cancer treatment, destroy not only cancer cells but also healthy cells, thus affecting germ cells as well.
One of the most important genes in the human genome is called p53 and its function is to suppress tumors.
First clinical trial looks at RG7112 as a way to disable MDM2 in leukemia.
Although p53 is called the â€œguardian of the genomeâ€, having the job of preventing defective cells from dividing, some cancer cells have found a loop hole.
It is common for cancer cells to find some way to disarm p53, also known as "guardian of the genome" due to its action in preventing defective cells from dividing.
New research links three molecules to a critical tumor suppressor gene that is often turned off in multiple myeloma, a presently incurable cancer of the blood.
- Large; stout; burly.