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Latest Mdm2 Stories

2009-11-11 16:55:55

The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity, according to a new study published online November 10 in the Journal of the National Cancer Institute. In this study in mice, Tom Van Maerken, M.D., Center for Medical Genetics, Ghent University Hospital in Belgium, and colleagues evaluated the antitumor efficacy of nutlin-3, a potent and selective antagonist of the p53"“MDM2 interaction. Researchers found that...

2009-11-09 14:41:47

Aggressive tumors lacking p53 protein stop dead in their tracks when p53's sister protein -- TAp63 -- steps in Oncologists have had their hands tied because more than half of all human cancers have mutations that disable a protein called p53. As a critical anti-cancer watchdog, p53 masterminds several cancer-fighting operations within cells. When cells lose p53, tumors grow aggressively and often cannot be treated. These tumors might be tough, but they're not invincible, suggests a new study...

2009-10-10 10:06:17

Researchers find new tumor suppressor destroys a key link in cancer chain A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell. "KEAP1 is a recently discovered tumor suppressor, but how it works has not been known. IKKß is a known oncoprotein that...

2009-07-07 16:06:24

A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors.Xiaoqi Liu, an assistant professor of biochemistry, found that an overabundance of the polo-like kinase 1, or Plk1, molecule during cell growth, as well as a shortage of the p53 molecule, will lead to tumor formation. Studies in Liu's laboratory showed that the Plk1 molecule indirectly attacks p53 in a process called ubiquitination."This provides the mechanism for how p53 loses...

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2009-07-06 13:15:00

A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells. In their latest study, scientists at the Salk Institute for Biological Studies suggest just how finely tuned the system is and how little it takes to tip the balance.When unprovoked, at least two negative regulators"”the related proteins Mdm2 and Mdmx"”prevent p53 from unleashing its power to...

2009-06-26 15:49:42

Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.The new protein, called Trim24, feeds p53 to a protein-shredding complex known as the proteasome by attaching targeting molecules called ubiquitins to the tumor suppressor, the team reported this week in the Proceedings of the National Academy of Sciences Online Early...

2009-03-25 08:07:09

Researchers may have found a more potent risk factor for melanoma than blistering sunburns, freckling, or family history of the deadly skin disease. In a new study, scientists at NYU Langone Medical Center report that a genetic variation leads to a nearly four-fold increase of melanoma in women under the age of 50. The new study was released online March 24, 2009, in the journal Clinical Cancer Research and will be published in the April 1, 2009, issue of the journal."If this number turns out...

2008-12-16 14:53:47

University of Rochester Medical Center scientists discovered a gene mutation that impairs the placenta and also is influential in cancer development, according to a study published online December 16, 2008, in the journal PLoS (Public Library of Science) Biology. The investigation is the first to link the key placental gene, SENP2, to the well-known p53 protein, which is defective in 50 percent of all cancers. Until now, the SENP2 gene's role in early embryo development was not known. As a...

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2006-07-05 18:05:00

By Will Boggs, MD NEW YORK (Reuters Health) - A variation of a cancer-causing gene called SNP309 interacts with an anti-cancer gene, known as p53, to influence a woman's odds of surviving breast cancer, according to a report in the Journal of the National Cancer Institute. Dr. Stefan Ambs, from the National Cancer Institute, Bethesda, Maryland, and colleagues investigated whether SNP309 was associated with breast cancer risk and outcome and whether it interacted with p53 to affect survival....

2005-10-07 13:07:31

Investigators at St. Jude Children's Research Hospital have discovered a previously unrecognized mechanism that controls a key protein linked to the cell's response to stress - a finding that holds promise for new ways to enhance cancer therapies or protect cells from dying after exposure to damaging chemicals or radiation. The gene for this protein, called p53, is the most commonly mutated gene in human cancer; and it plays a critical role in helping cells respond to stress, especially...


Word of the Day
out-herod
  • In the phrase to out-herod Herod, to be more violent than Herod (as represented in the old mystery plays); hence, to exceed in any excess of evil.
Herod refers to 'Herod the Great,' a Roman client king and 'a madman who murdered his own family and a great many rabbis.' According to the OED, the term is 'chiefly with allusion to Shakespeare's use' in Hamlet.
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