Latest Mdm2 Stories

2009-12-02 11:17:17

A large proportion of late-stage breast cancers that have spread to other parts of the body (metastatic breast cancers) are characterized by overexpression of the protein Mdm2.

2009-11-11 16:55:55

The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity.

2009-11-09 14:41:47

Aggressive tumors lacking p53 protein stop dead in their tracks when p53's sister protein -- TAp63 -- steps in.

2009-10-10 10:06:17

A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell.

2009-07-07 16:06:24

A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors. Xiaoqi Liu, an assistant professor of biochemistry.

2009-07-06 13:15:00

A tightly controlled system of checks and balances ensures that a powerful tumor suppressor called p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells.

2009-06-26 15:49:42

Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.

2009-03-25 08:07:09

Researchers may have found a more potent risk factor for melanoma than blistering sunburns, freckling, or family history of the deadly skin disease.

2008-12-16 14:53:47

University of Rochester Medical Center scientists discovered a gene mutation that impairs the placenta and also is influential in cancer development.

2006-07-05 18:05:00

A variation of a cancer-causing gene called SNP309 interacts with an anti-cancer gene, known as p53, to influence a woman's odds of surviving breast cancer, according to a report in the Journal of the National Cancer Institute.