Quantcast
Last updated on April 21, 2014 at 12:45 EDT

Latest Mechanotransduction Stories

2013-06-12 16:08:32

Mechanism offers potential for interventions that could save hearing A team of NIH-supported researchers is the first to show, in mice, an unexpected two-step process that happens during the growth and regeneration of inner ear tip links. Tip links are extracellular tethers that link stereocilia, the tiny sensory projections on inner ear hair cells that convert sound into electrical signals, and play a key role in hearing. The discovery offers a possible mechanism for potential...

Molecule That Converts Sound Into Brain Signals Found
2012-12-07 12:39:03

April Flowers for redOrbit.com - Your Universe Online Finding the exact genetic code that programs the ear´s machinery for responding to sound waves and converting them into electrical impulses in the inner ear has been something of a holy grail for the scientists who study the genetics of hearing and deafness. A new study from The Scripps Research Institute (TSRI) has brought this search to fruition by identifying a critical component of the ear-to-brain conversation. This...

2012-02-20 15:02:27

In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch." Scientists have known that sensory nerves in our skin detect pressure, pain, heat, cold, and other stimuli using specialized "ion channel" proteins in their outer membranes. They have only just begun, however, to identify and characterize the specific proteins involved in each of these sensory pathways. The...

2011-12-27 08:00:00

SINGAPORE, Dec. 27, 2011 /PRNewswire/ -- The Intellectual Property portfolio of TIGR® Matrix Surgical Mesh has been further complimented with the granting of a second U.S. patent related to material degradation and mechanical behaviour. TIGR® Matrix was developed based on the hypothesis that soft tissue positively remodels in response to the stimulus of increased mechanical load - a process known as 'mechanotransduction', which is the physiological process by which cells...

2011-11-21 23:07:23

Discovery may accelerate advances in understanding and treating hearing loss National Institutes of Health-funded researchers have identified two proteins that may be the key components of the long-sought after mechanotransduction channel in the inner ear–the place where the mechanical stimulation of sound waves is transformed into electrical signals that the brain recognizes as sound. The findings are published in the Nov. 21 online issue of The Journal of Clinical Investigation....

2011-03-07 12:23:17

Presentation today at Biophysical Society Meeting in Baltimore From grinding heavy metal to soothing ocean waves, the sounds we hear are all perceptible thanks to the vibrations felt by tiny molecular motors in the hair cells of the inner ear. Researchers at the University of Pennsylvania School of Medicine have now identified the mechanism by which a single amino acid change can disrupt the normal functioning of one of the critical components of that physiology -- a molecular motor protein...

2010-09-03 12:43:14

Findings could lead to new treatment approaches in pain, deafness and cardiac function Scripps Research Institute scientists have identified two proteins with potential to be important targets for research into a wide range of health problems, including pain, deafness, and cardiac and kidney dysfunction. The study was published in Science Express, the advanced, online edition of the journal Science, on September 2, 2010. In the study, the Scripps Research scientists identify two proteins,...

2009-05-13 15:12:36

Finding may lead to better understanding of how body responds to mechanical stimuli Scientists from The Scripps Research Institute have elucidated the action of a protein, harmonin, which is involved in the mechanics of hearing. This finding sheds new light on the workings of mechanotransduction, the process by which cells convert mechanical stimuli into electrical activity. Defects in mechanotransduction genes can cause devastating diseases, such as Usher's syndrome, which is characterized...