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2010-08-16 08:45:00

Protein linked to mental retardation may be controlling factor in drug's effect in the brain Scientists from the Florida campus of The Scripps Research Institute have identified a protein that may act as the trigger controlling the addictive impact of cocaine in the brain. The findings may one day lead to new therapies to treat addiction. The study was published on August 15, 2010, in the prestigious journal Nature Neuroscience. The results from the new study strongly suggest that a protein...

2010-07-12 13:50:34

Findings may lead to new drug targets A subtle mutation affecting the epigenome "“ a set of dynamic factors that influence gene activity -- may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. The disorder, which also involves cleft lip or cleft palate, appears to hinge on an enzyme working in a biological pathway that may offer several potential drug targets. The study, published online July 11 in the journal Nature,...

2010-02-25 13:44:55

A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a regulator of specific genes. Mutations in MeCP2 cause the autism spectrum disorder Rett Syndrome as well as some cases of neuropsychiatric problems including autism, schizophrenia and learning disabilities. The discovery of MeCP2's global reach was made in the laboratory of Adrian Bird, Ph.D. of the University of Edinburgh. Bird's...

2009-12-08 17:57:55

Loss of the gene that causes Rett syndrome disrupts the production of neurotransmitters in specific nerve cells, causing the movement and behavioral problems typical of the disease, said a research team led by those at Baylor College of Medicine in a report online today in the Proceedings of the National Academy of Sciences. "Abnormalities in MeCP2 (methyl-CpG binding protein) lead to decreased production of enzymes that control production of the neurotransmitters dopamine, norepinephrine and...

2009-10-27 12:00:00

CINCINNATI, Oct. 27 /PRNewswire/ -- Inspired by recent breakthroughs in research, today the International Rett Syndrome Foundation (IRSF) announced a major fundraising initiative entitled Research to Reality: Funding Progress. Funds raised by the campaign are earmarked to accelerate the progress of crucial research, and bring promise to reality. Country music sensation Clint Black, whose niece Courtney lost her battle with Rett syndrome in 2003 at age 16, will serve as Honorary Chair of...

2009-08-19 14:43:36

U.S. and Norwegian scientists say they've shown gene changes are linked with brain structure changes in healthy people, as well as those with brain disorders. A research team from Ullelval University Hospital and the University of Oslo, both in Norway; the University of California-San Diego; and the Scripps Translational Science Institute in La Jolla, Calif., examined 944 healthy people, as well as patients with Alzheimer's disease and those with psychotic disorders. A genetic analysis and a...

2009-08-18 13:45:00

Using advanced brain imaging and genomics technologies, an international team of researchers co-led by Scripps Research Institute scientists has shown for the first time that natural variations in a specific gene influence brain structure. By establishing this link, the researchers have opened the door to a range of potential research efforts that could reveal gene variations responsible for a number of neurological conditions such as autism.The work was reported in an advance, online Early...

2009-08-18 10:50:51

An international group of researchers is the first to show that common variations in a gene "“ previously shown to be associated with Retts Syndrome, autism, and mental retardation "“ are associated with differences in brain structure in both healthy individuals and patients with neurological and psychiatric disorders. Their findings will be published in the early online edition of the Proceedings of the National Academy of Sciences the week of August 17."We studied not only the...

2009-04-20 09:58:52

A research collaboration between Australia and Israel has identified a genetic variation that influences the severity of symptoms in Rett syndrome. The finding is published in the latest edition of the international journal Neurology. Dr Helen Leonard, who heads the Australian Rett Syndrome Study at the Telethon Institute for Child Health Research, said the finding was exciting in that it identifies a potential new target for treatment of the debilitating neurological disorder. "We know that...

2008-10-07 15:00:10

Could new findings about Rett syndrome lead the way in developing new techniques for unraveling other diseases that affect the brain? October is Rett Syndrome Awareness Month, and over 800 of the world's leading Rett Syndrome researchers, clinicians, organizations and families will meet at the Maison de la Mutualie, Paris October 10 -13 for the 6th World Rett Syndrome Congress hosted by Professor Philippe Evrard, who leads a research department in neurosciences in brain development and...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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