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Latest Medulloblastoma Stories

2010-12-17 13:04:25

Scientists at the Johns Hopkins Kimmel Cancer Center have deciphered the genetic code for medulloblastoma, the most common pediatric brain cancer and a leading killer of children with cancer. The genetic "map" is believed to be the first reported of a pediatric cancer genome and is published online in the December 16 issue of Science Express. Notably, the findings show that children with medulloblastoma have five- to tenfold fewer cancer-linked alterations in their genomes compared with their...

2010-12-17 13:02:35

Comprehensive study of medulloblastoma suggests targeted drugs may be especially effective in children Pediatric cancer researchers at The Children's Hospital of Philadelphia contributed important expertise to a new landmark study of medulloblastoma, a type of brain tumor typically found in children. The large multicenter study defines the genetic landscape of this cancer, and holds intriguing clues to gene changes on signaling pathways that may become fruitful targets for future therapies....

2010-12-08 22:14:33

International effort led by St. Jude Children's Research Hospital scientists is expected to fuel development of targeted therapies and aid the search for unique combinations of cells and mutations that lead to other cancers Investigators have demonstrated for the first time that the most common malignant childhood brain tumor, medulloblastoma, is actually several different diseases, each arising from distinct cells destined to become different structures. The breakthrough is expected to...

2010-11-22 21:10:59

Largest genomic study of human medulloblastomas to date improves ability to direct treatment Medulloblastomas are the most common malignant brain tumors of childhood, with 40 to 50 percent overall mortality. One of the greatest challenges in treating them is that they vary substantially from patient to patient. In the largest genomic study of human medulloblastomas to date, researchers from Children's Hospital Boston, together with collaborators, have identified six subtypes with distinct...

2010-05-27 10:26:38

The use of modified measles virus may represent a new treatment for a childhood brain tumor known as medulloblastoma, according to a new study appearing in Neuro-Oncology. Medulloblastoma is the most common malignant central nervous system tumor of childhood, accounting for about 20 percent of pediatric brain tumors. These tumors are located in the cerebellum, the area of the brain that controls balance and other complex motor functions. Refinements in treatment have increased the 5-year...

2010-04-06 08:44:33

Src (short for sarcoma) is a family of proto-oncogenic tyrosine kinases active in many cancer tumors, including medulloblastoma, the most common malignant cancer in children. Src represents one of the most promising targets for cancer therapy. A recent study shows that pyrazolo-[3,4-d]"“pyrimidine-derivatives, designed to target Src, may be effective in interfering with the cell cycle and causing cancer cell death in medulloblastoma. The results were published in FASEB (The Journal of...

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2010-02-02 09:13:10

The role that the master gene Math1 plays in making a critical population of cells called granule neurons in the cerebellum also points to its involvement in the development of a common childhood brain tumor called medulloblastoma. This finding helps explain the continuous proliferation or reproduction of the tumor cells, said researchers from Baylor College of Medicine in a report in a recent issue of the journal Science. New target for treatment Understanding the role of Math1 could help...

2010-01-11 07:58:43

New research from scientists at Queen Mary, University of London shows how the most common type of children's brain cancer can arise from stem cells. Scientists know relatively little about medulloblastomas or why some cases respond better to treatments than others. The new research, published Jan. 10 in Oncogene*, shows that medulloblastomas can grow from a type of brain stem cell and that these cancers are a distinct form of the disease which may require a completely different approach to...

2009-12-03 22:15:00

The master gene Math1 is involved in the genesis of the most common childhood brain tumor, medulloblastoma, said researchers from Baylor College of Medicine (www.bcm.edu) in a report in the current issue of the journal Science. The finding provides a new treatment target in the deadly disease that most commonly affects children and young adults, said Dr. Huda Zoghbi (http://www.bcm.edu/pediatrics/index.cfm?Realm=99992437&This_Template=huda_zoghbi,...

2009-12-03 21:25:41

Howard Hughes Medical Institute (HHMI) researchers have identified a new factor that is necessary for the development of many forms of medulloblastoma, the most common type of malignant childhood brain cancer. HHMI investigator Huda Y. Zoghbi and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1 in susceptible brain cells. The team's findings, reported in the December 4, 2009, issue of Science, suggest...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'