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Last updated on April 18, 2014 at 21:21 EDT

Latest Medulloblastoma Stories

2010-11-22 21:10:59

Largest genomic study of human medulloblastomas to date improves ability to direct treatment Medulloblastomas are the most common malignant brain tumors of childhood, with 40 to 50 percent overall mortality. One of the greatest challenges in treating them is that they vary substantially from patient to patient. In the largest genomic study of human medulloblastomas to date, researchers from Children's Hospital Boston, together with collaborators, have identified six subtypes with distinct...

2010-05-27 10:26:38

The use of modified measles virus may represent a new treatment for a childhood brain tumor known as medulloblastoma, according to a new study appearing in Neuro-Oncology. Medulloblastoma is the most common malignant central nervous system tumor of childhood, accounting for about 20 percent of pediatric brain tumors. These tumors are located in the cerebellum, the area of the brain that controls balance and other complex motor functions. Refinements in treatment have increased the 5-year...

2010-04-06 08:44:33

Src (short for sarcoma) is a family of proto-oncogenic tyrosine kinases active in many cancer tumors, including medulloblastoma, the most common malignant cancer in children. Src represents one of the most promising targets for cancer therapy. A recent study shows that pyrazolo-[3,4-d]"“pyrimidine-derivatives, designed to target Src, may be effective in interfering with the cell cycle and causing cancer cell death in medulloblastoma. The results were published in FASEB (The Journal of...

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2010-02-02 09:13:10

The role that the master gene Math1 plays in making a critical population of cells called granule neurons in the cerebellum also points to its involvement in the development of a common childhood brain tumor called medulloblastoma. This finding helps explain the continuous proliferation or reproduction of the tumor cells, said researchers from Baylor College of Medicine in a report in a recent issue of the journal Science. New target for treatment Understanding the role of Math1 could help...

2010-01-11 07:58:43

New research from scientists at Queen Mary, University of London shows how the most common type of children's brain cancer can arise from stem cells. Scientists know relatively little about medulloblastomas or why some cases respond better to treatments than others. The new research, published Jan. 10 in Oncogene*, shows that medulloblastomas can grow from a type of brain stem cell and that these cancers are a distinct form of the disease which may require a completely different approach to...

2009-12-03 22:15:00

The master gene Math1 is involved in the genesis of the most common childhood brain tumor, medulloblastoma, said researchers from Baylor College of Medicine (www.bcm.edu) in a report in the current issue of the journal Science. The finding provides a new treatment target in the deadly disease that most commonly affects children and young adults, said Dr. Huda Zoghbi (http://www.bcm.edu/pediatrics/index.cfm?Realm=99992437&This_Template=huda_zoghbi,...

2009-12-03 21:25:41

Howard Hughes Medical Institute (HHMI) researchers have identified a new factor that is necessary for the development of many forms of medulloblastoma, the most common type of malignant childhood brain cancer. HHMI investigator Huda Y. Zoghbi and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1 in susceptible brain cells. The team's findings, reported in the December 4, 2009, issue of Science, suggest...

2009-09-02 23:50:00

The Hedgehog signaling pathway is involved in a preliminary study and case report describing positive responses to an experimental anticancer drug in a majority of people with advanced or metastatic basal cell skin cancers. One patient with the most common type of pediatric brain cancer, medulloblastoma, also showed tumor shrinkage. Initial results of the drug trial, conducted at Johns Hopkins (Baltimore), the Karmanos Cancer Center (Detroit) and the Translational Genomics Research Institute...

2009-03-10 14:19:07

A discovery in Canada could help more children survive brain cancer. Research funded by the Canadian Cancer Society discovered eight similar genes that when mutated, appear to be responsible for medulloblastoma, the most common form of childhood brain cancers. Researchers learned when the eight genes are functioning normally it appears their role is to make proteins that tell the developing brain when to stop growing. They said when the genes are mutated the brain may continue to grow out of...

2009-03-09 13:13:02

Canadian scientists say they've discovered eight similar genes that, when mutated, appear to cause medulloblastoma -- a common childhood brain cancer. This discovery is very promising and may help researchers develop better, more targeted treatments so that more of these children will survive and fewer will suffer debilitating side effects, said Christine Williams, director of research programs for the Canadian Cancer Society Research Institute. The study was led by Dr. Michael Taylor, a...