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Latest Mef2 Stories

2012-01-05 16:26:53

A potential target for schistosomiasis vaccine In the complicated life cycle of ancient flatworms that cause schistosomiasis, Case Western Reserve University researchers have identified a gene activator crucial to development of the parasites within humans — a potential target for a vaccine. A description of the activator, which turns on rapid growth, is in the online journal PLoS Neglected Tropical Diseases. Schistosomiasis, which causes organ damage and failure, afflicts more...

2010-04-09 09:38:00

As published today in Science, researchers from Cambridge, Glasgow and Greece have discovered a remarkable amount of plasticity in how transcription factors, the proteins that bind to DNA to control the activation of genes, maintain their function over large evolutionary distances. The text books tell us that transcription factors recognize the genes that they regulate by binding to short, sequence-specific lengths of DNA upstream or downstream of their target genes. It was widely assumed...

2009-01-02 09:14:42

Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson's disease and other neurodegenerative diseases. The presence of Lewy bodies suggests underlying problems in protein recycling and waste disposal, leading to the puzzle: how does disrupting those processes kill brain cells? One possible answer: by breaking a survival circuit called MEF2D. Researchers at Emory University School of Medicine have...

2008-06-30 18:03:00

In a breakthrough scientific study published today in the Proceedings of the National Academy of Sciences, scientists at the Burnham Institute for Medical Research have shown that neural stem cell development may be linked to Autism. The study demonstrated that mice lacking the myocyte enhancer factor 2C (MEF2C) protein in neural stem cells had smaller brains, fewer nerve cells and showed behaviors similar to those seen in humans with a form of autism known as Rett Syndrome. This work...

2005-08-31 18:45:31

DALLAS "“ Aug. 31, 2005 "“ By studying the molecules that regulate the formation of muscle, researchers at UT Southwestern Medical Center have discovered a gene that may play a role in a rare muscular disease in humans. While the researchers studied mice, they are now looking for patients who have mutations in this newly discovered muscle gene, Srpk3. Mice that lack the gene have a condition much like the human disease, centronuclear myopathy. "It's easy to imagine that human...


Word of the Day
humgruffin
  • A terrible or repulsive person.
Regarding the etymology of 'humgruffin,' the OED says (rather unhelpfully) that it's a 'made-up word.' We might guess that 'hum' comes from 'humbug' or possibly 'hum' meaning 'a disagreeable smell,' while 'gruffin' could be a combination of 'gruff' and 'griffin.'