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Latest Membrane biology Stories

2013-09-30 14:10:50

The outer membrane of bacteria contains many proteins that form tiny pores. They are important for absorbing nutrients and transmitting signals into the cell. The research group of Sebastian Hiller, Professor of Structural Biology at the Biozentrum, University of Basel, has now shown for the first time at atomic resolution, that these pore proteins are transported in an unstructured, constantly changing state to the outer bacterial membrane. This landmark study was recently published in the...

2013-09-23 14:00:33

Eukaryotic cells are compartmentalized by membranes, whose shape and dynamics are precisely regulated to maintain their correct functions. Consequently, many cellular processes such as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes. BAR domain proteins are among the central membrane-sculpting proteins in all eukaryote cells. Studies by Pekka Lappalainen laboratory at Institute of Biotechnology, University of...

2013-09-06 12:26:52

Study uses induced pluripotent stem cells to identify kidney disease defect New research has uncovered a process that is defective in patients with autosomal dominant polycystic kidney disease, a common cause of kidney failure. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), point to a new potential strategy for preventing and treating the disease. Polycystic kidney disease (PKD), the fourth leading cause of kidney failure...

2013-08-15 20:47:35

Scientists working at the Research Center on Aging at the Health and Social Services Centre — University Institute of Geriatrics of Sherbrooke (CSSS-IUGS) have been studying strategies for protecting retinal pigment epithelium (RPE) cells. Dysfunction of the RPE is found in retinopathy and age-related macular degeneration, which is the leading cause of blindness of elderly people in developed countries. Findings published today in the Canadian Journal of Physiology and Pharmacology...

Biophysicists Zoom In On Pore-forming Toxin
2013-08-15 09:08:14

Rice University Study of melittin-based pore formation also applies to anticancer drugs A new study by Rice University biophysicists offers the most comprehensive picture yet of the molecular-level action of melittin, the principal toxin in bee venom. The research could aid in the development of new drugs that use a similar mechanism as melittin's to attack cancer and bacteria. The study appears this week in the Proceedings of the National Academy of Sciences. Melittin does its...

2013-08-09 09:50:20

Researchers from Tubingen resolve how a plant steroid hormone makes plants grow If one wants to better understand how plants grow, one must analyze the chemistry of life in its molecular detail. Michael Hothorn from the Friedrich-Miescher-Laboratory of the Max Planck Society in Tübingen and his team are doing just that. Their latest work now reveals that a plant membrane receptor requires a helper protein to sense a growth-promoting steroid hormone and to transduce this signal across the...

2013-08-08 11:02:05

Study could help yield new drugs for brain disorders Johns Hopkins biophysicists have discovered that full activation of a protein ensemble essential for communication between nerve cells in the brain and spinal cord requires a lot of organized back-and-forth motion of some of the ensemble's segments. Their research, they say, may reveal multiple sites within the protein ensemble that could be used as drug targets to normalize its activity in such neurological disorders as epilepsy,...


Latest Membrane biology Reference Libraries

Esophagus
2013-04-30 13:37:01

The esophagus is the muscular tube that is located between the pharynx and the stomach that aids in digestion during swallowing. Formation and Orientation The esophagus is composed of four separate layers; the mucosa, submucosa, muscularis externa and the adventitia. The mucosa includes the stratified squamous epithelium, lamina propria and muscularis mucosae. The submucosa houses the esophageal glands and connective papillae. The muscularis externa is composed of three sublayers The...

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Word of the Day
barghest
  • A goblin in English folklore, often appearing in the shape of a large dog and believed to portend imminent death or misfortune.
  • A ghost, wraith, hobgoblin, elf, or spirit.
The origin of 'barghest' is not known, but it may be from perhaps burh-ghest, town-ghost, or German Berg-geist (mountain spirit) or Bär-geist (bear-spirit).
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