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Last updated on April 19, 2014 at 18:42 EDT

Latest Mendelian randomization Stories

2013-06-11 12:52:42

Low levels of vitamin D can trigger hypertension, according to the world's largest study to examine the causal association between the two. Although observational studies have already shown this link, a large-scale genetic study was necessary before the cause and effect could be proven, the annual conference of the European Society of Human Genetics (ESHG) will hear today (Tuesday). Dr. Vimal Karani S, from the Institute of Child Health, University College London, London, UK, will tell the...

2012-05-02 09:51:20

A Mendelian randomization analysis conducted by Børge Nordestgaard of Copenhagen University Hospital, Denmark and colleagues, using data from observational studies, supports a causal relationship between body mass index (BMI) and risk for ischemic heart disease (IHD). The findings, published in this week's PLoS Medicine, have important implications for public health policy because they show that the association between BMI (which is modifiable by lifestyle changes) and IHD is...

2012-03-22 22:44:15

Many observational cohort studies have shown that moderate alcohol use is associated with better cognitive function. However, since such studies are vulnerable to residual confounding by other lifestyle and physiologic factors, the authors conducted a Mendelian randomization study, using aldehyde dehydrogenase 2 (ALDH2) genotype (AA, GA, or GG) as an instrumental variable in 2-stage least squares analysis. Cognitive function was assessed from delayed 10-word recall score (n = 4,707) and...

2009-06-30 15:51:56

An analysis of the association between genetic variations of the inflammation biomarker C-reactive protein (CRP) with coronary heart disease failed to support a causal association, according to a study in the July 1 issue of JAMA.Coronary heart disease (CHD) is the leading cause of death worldwide. Inflammation plays a key role in the development of CHD at every stage, from initiation to progression and rupture of plaque. CRP is currently the most widely used biomarker of inflammation,...