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Latest Mendelian randomization Stories

2014-06-28 09:41:35

The Lancet New genetic research provides compelling evidence that low levels of vitamin D have a causal role in the development of high blood pressure (hypertension). The findings, published in The Lancet Diabetes & Endocrinology, suggest that vitamin D supplementation could be effective in combating some cases of hypertension. "In view of the costs and side effects associated with antihypertensive drugs, the potential to prevent or reduce blood pressure and therefore the risk of...

2013-06-11 12:52:42

Low levels of vitamin D can trigger hypertension, according to the world's largest study to examine the causal association between the two. Although observational studies have already shown this link, a large-scale genetic study was necessary before the cause and effect could be proven, the annual conference of the European Society of Human Genetics (ESHG) will hear today (Tuesday). Dr. Vimal Karani S, from the Institute of Child Health, University College London, London, UK, will tell the...

2012-05-02 09:51:20

A Mendelian randomization analysis conducted by Børge Nordestgaard of Copenhagen University Hospital, Denmark and colleagues, using data from observational studies, supports a causal relationship between body mass index (BMI) and risk for ischemic heart disease (IHD). The findings, published in this week's PLoS Medicine, have important implications for public health policy because they show that the association between BMI (which is modifiable by lifestyle changes) and IHD is...

2012-03-22 22:44:15

Many observational cohort studies have shown that moderate alcohol use is associated with better cognitive function. However, since such studies are vulnerable to residual confounding by other lifestyle and physiologic factors, the authors conducted a Mendelian randomization study, using aldehyde dehydrogenase 2 (ALDH2) genotype (AA, GA, or GG) as an instrumental variable in 2-stage least squares analysis. Cognitive function was assessed from delayed 10-word recall score (n = 4,707) and...

2009-06-30 15:51:56

An analysis of the association between genetic variations of the inflammation biomarker C-reactive protein (CRP) with coronary heart disease failed to support a causal association, according to a study in the July 1 issue of JAMA.Coronary heart disease (CHD) is the leading cause of death worldwide. Inflammation plays a key role in the development of CHD at every stage, from initiation to progression and rupture of plaque. CRP is currently the most widely used biomarker of inflammation,...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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