Latest Merkel cell polyomavirus Stories
ROCKLAND, Massachusetts, July 29, 2014 /PRNewswire/ -- - First patient begins treatment in an international Phase II study investigating the efficacy
Trial to evaluate ID-G100 in patients with Merkel cell carcinoma SEATTLE and SOUTH SAN FRANCISCO, Calif., Jan.
Four years after they discovered the viral roots of a rare skin cancer, researchers at the University of Pittsburgh Cancer Institute (UPCI) and the School of Medicine have now identified a molecule activated by this virus that, in animal studies, could be targeted to selectively kill the tumor cells.
The Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be associated with a rare skin cancer, known as Merkel cell carcinoma, according to a new study published online September 23 in the Journal of the National Cancer Institute.
Polyomavirus is the sole genus of viruses within the family Polyomaviridae. Ludwik Gross discovered the first polyomavirus, Murine polyomavirus, in 1963. Many polyomaviruses infect birds and mammals and have been extensively studied as tumor viruses in humans and animals. Polyomaviruses are DNA-based, small, and icosahedral in shape. They can potentially cause tumors and often persist as latent infections in a host without causing disease. There are three major clades or...
Merkel cell polyomavirus (MCV or MCPyV), first discovered in January 2008, is one of seven human tumor viruses. It is suspected to cause most of Merkel cell carcinoma which is a rare, aggressive form of skin cancer. Around 80% of Merkel cell carcinoma tumors are found to be infected with MCV. It is found in respiratory secretions suggesting that it may be transmitted by a respiratory route. Usually the tumors with MCV viruses go through at least two mutations that render the virus...