Latest Messenger RNA Stories
A new level of variation in messenger RNAs exposed Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings, published today in...
NEW YORK, April 16, 2013 /PRNewswire/ -- Exosome Diagnostics, a developer of biofluid-based molecular diagnostic products for use in personalized medicine, today announced data demonstrating exosome technology performance in clinical applications which will be presented at the International Society for Extracellular Vesicles 2013 (ISEV 2013) annual meeting, April 16-20, in Boston. The ISEV meeting is the preeminent international conference in the rapidly growing field of exosome and...
SANTA CRUZ, Calif., Nov. 12, 2012 /PRNewswire/ -- SomaGenics, Inc., a biotechnology company specializing in RNA-based technologies, has been awarded US Patent No. 8,283,460 for key aspects of the company's sshRNA therapeutic platform. sshRNAs are small synthetic stem-loop (or hairpin) RNAs that the company's researchers have shown to be highly potent in knocking down target RNAs through an RNA interference (RNAi) mechanism. SomaGenics' lead therapeutic program targets hepatitis C,...
Scientists have adopted a novel laboratory approach for determining the effect of genetic variation on the efficiency of the biological process that translates a gene's DNA sequence into a protein, such as hemoglobin, according to a presentation, Nov. 6, at the American Society of Human Genetics 2012 meeting in San Francisco. In the 0.1% of the DNA that differs between any two individuals, scientists search for the biological mechanisms underlying human genetic differences, including...
TUBINGEN, Germany, Sept. 18, 2012 /PRNewswire/ -- CureVac GmbH, a clinical stage biopharmaceutical company developing a new class of therapies and vaccines based on mRNA, today announced the completion of an EUR80 million financing round with its main investor, dievini Hopp BioTech Holding. In the next years, CureVac will use the proceeds mainly to advance the development of its two lead RNActive® cancer vaccines against prostate cancer and non-small cell lung cancer (NSCLC),...
TUCSON, Ariz., Sept. 6, 2012 /PRNewswire/ -- Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, is introducing a first-of-its-kind fully-automated staining technique that will allow researchers to examine miRNAs and proteins related to cancer in the same section of tumor tissue. Detecting miRNAs and proteins together, in the context of the tumor microenvironment, allows researchers to visualize the association of oncogenic protein expression to those miRNAs...
Targeted 'negative ASOs' cause missplicing and pathogenesis, providing unique window on disease progression A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases – those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders to...
ALBANY, New York, August 6, 2012 /PRNewswire/ -- New Report Added in ResearchMoz Reports Database "MicroRNAs and Exosomes Market Report 2012 [http://www.researchmoz.us/micrornas-and-exosomes-market-report-2012-report.html ]" This is the latest and most up-to-date Market Report from Select Biosciences addressing the microRNA and Exosomes markets as they are evolving. In this report, we focus upon the microRNA research marketplace from the perspective of the...
Structural analysis opens the way to new anti-influenza drugs Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus' RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS Pathogens. The research was done on the 2009 pandemic influenza strain but it will help scientists to design innovative drugs against all the...
MicroRNAs (miRNAs) are endogenously encoded RNAs that regulate the stability or translation of mRNA molecules, and emerging research suggests that they have diverse roles in normal physiology and disease. In this issue, two groups investigated the role of the predominant liver miRNA, miR-122. Ann-Ping Tsou and colleagues from National Yang-Ming University in Taiwan, and a team led by Kalpana Ghoshal, from Ohio State University generated mouse models of MiR-122 loss of function, and determined...
