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Latest Messenger RNA Stories

2013-11-05 12:28:08

Experts from Industry and Academia Discussed the Medical Potential of Messenger RNA (mRNA) TUEBINGEN, Germany, Nov. 5, 2013 /PRNewswire/ -- The 1st International mRNA Health Conference in Tuebingen on Oct. 23 and 24 brought together for the first time more than 150 attendees from leading international pharmaceutical and biotechnology companies and academic institutions. The attendees discussed in the two-day event the tremendous medical potential of mRNA for many therapeutic...

How Rare 'Words' In Bacterial Genes Boost Protein Production
2013-09-27 07:29:50

Wyss Institute for Biologically Inspired Engineering at Harvard Scientists routinely seek to reprogram bacteria to produce proteins for drugs, biofuels and more, but they have struggled to get those bugs to follow orders. But a hidden feature of the genetic code, it turns out, could get bugs with the program. The feature controls how much of the desired protein bacteria produce, a team from the Wyss Institute for Biologically Inspired Engineering at Harvard University reported in the...

2013-08-21 10:43:26

Researchers have long known that high levels of a specific protein in human cells are linked to tumor growth – but no one has fully understood how. Now, a groundbreaking discovery by UC Davis graduate student Kateryna Feoktistova and Assistant Professor Christopher Fraser illuminates the way that the protein, eukaryotic initiation factor 4E (eIF4E), acts upon cancer-promoting messenger RNA molecules. When translated, this type of mRNA can trigger the runaway cell replication that results...

2013-07-01 11:55:56

Synthetic biology technology could lead to new antibiotics, modified protein-generators Synthetic biology researchers at Northwestern University, working with partners at Harvard Medical School, have for the first time synthesized ribosomes -- cell structures responsible for generating all proteins and enzymes in our bodies -- from scratch in a test tube. Others have previously tried to synthesize ribosomes from their constituent parts, but the efforts have yielded poorly functional...

This Image May Lead To Better Antibiotics
2013-06-28 13:45:14

Lawrence Berkeley National Laboratory Berkeley Lab scientists create atomic-scale structure of ribosome attached to a molecule that controls its motion This may look like a tangle of squiggly lines, but you're actually looking at a molecular machine called a ribosome. Its job is to translate DNA sequences into proteins, the workhorse compounds that sustain you and all living things. The image is also a milestone. It's the first time the atom-by-atom structure of the ribosome has been...

2013-06-17 09:56:18

Because of their central importance to biology, proteins have been the focus of intense research, particularly the manner in which they are produced from genetically coded templates–a process commonly known as translation. While the general mechanism of translation has been understood for some time, protein synthesis can initiate by more than one mechanism. One of the least well understood mechanisms is known as cap-independent translation. Now, John Chaput and his colleagues at...

2013-04-25 19:56:01

A new level of variation in messenger RNAs exposed Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings, published today in...

2013-04-16 08:29:05

NEW YORK, April 16, 2013 /PRNewswire/ -- Exosome Diagnostics, a developer of biofluid-based molecular diagnostic products for use in personalized medicine, today announced data demonstrating exosome technology performance in clinical applications which will be presented at the International Society for Extracellular Vesicles 2013 (ISEV 2013) annual meeting, April 16-20, in Boston. The ISEV meeting is the preeminent international conference in the rapidly growing field of exosome and...

2012-11-12 08:28:11

SANTA CRUZ, Calif., Nov. 12, 2012 /PRNewswire/ -- SomaGenics, Inc., a biotechnology company specializing in RNA-based technologies, has been awarded US Patent No. 8,283,460 for key aspects of the company's sshRNA therapeutic platform. sshRNAs are small synthetic stem-loop (or hairpin) RNAs that the company's researchers have shown to be highly potent in knocking down target RNAs through an RNA interference (RNAi) mechanism. SomaGenics' lead therapeutic program targets hepatitis C, and a...

2012-11-07 11:49:14

Scientists have adopted a novel laboratory approach for determining the effect of genetic variation on the efficiency of the biological process that translates a gene's DNA sequence into a protein, such as hemoglobin, according to a presentation, Nov. 6, at the American Society of Human Genetics 2012 meeting in San Francisco. In the 0.1% of the DNA that differs between any two individuals, scientists search for the biological mechanisms underlying human genetic differences, including...