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Latest Messenger RNA Stories

2012-09-17 22:21:07

TUBINGEN, Germany, Sept. 18, 2012 /PRNewswire/ -- CureVac GmbH, a clinical stage biopharmaceutical company developing a new class of therapies and vaccines based on mRNA, today announced the completion of an EUR80 million financing round with its main investor, dievini Hopp BioTech Holding. In the next years, CureVac will use the proceeds mainly to advance the development of its two lead RNActive® cancer vaccines against prostate cancer and non-small cell lung cancer (NSCLC),...

2012-09-06 06:27:55

TUCSON, Ariz., Sept. 6, 2012 /PRNewswire/ -- Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, is introducing a first-of-its-kind fully-automated staining technique that will allow researchers to examine miRNAs and proteins related to cancer in the same section of tumor tissue. Detecting miRNAs and proteins together, in the context of the tumor microenvironment, allows researchers to visualize the association of oncogenic protein expression to those miRNAs involved in the...

2012-08-15 11:57:20

Targeted 'negative ASOs' cause missplicing and pathogenesis, providing unique window on disease progression A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases — those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders...

2012-08-06 02:25:34

ALBANY, New York, August 6, 2012 /PRNewswire/ -- New Report Added in ResearchMoz Reports Database "MicroRNAs and Exosomes Market Report 2012 [http://www.researchmoz.us/micrornas-and-exosomes-market-report-2012-report.html ]" This is the latest and most up-to-date Market Report from Select Biosciences addressing the microRNA and Exosomes markets as they are evolving. In this report, we focus upon the microRNA research marketplace from the perspective of the translational...

2012-08-04 01:12:36

Structural analysis opens the way to new anti-influenza drugs Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus' RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS Pathogens. The research was done on the 2009 pandemic influenza strain but it will help scientists to design innovative drugs against all the...

2012-07-23 20:56:11

MicroRNAs (miRNAs) are endogenously encoded RNAs that regulate the stability or translation of mRNA molecules, and emerging research suggests that they have diverse roles in normal physiology and disease. In this issue, two groups investigated the role of the predominant liver miRNA, miR-122. Ann-Ping Tsou and colleagues from National Yang-Ming University in Taiwan, and a team led by Kalpana Ghoshal, from Ohio State University generated mouse models of MiR-122 loss of function, and determined...

2012-07-20 01:50:16

New research has shown that a protein does something that scientists once thought impossible: It unfolds itself and refolds into a completely new shape. This protein, called RfaH, activates genes that allow bacterial cells to launch a successful attack on their host, causing disease. The researchers determined that RfaH starts out in its alpha form, composed of two spiral shapes. Later, in its beta form, it resembles spokes on a wheel and is called a barrel. When RfaH refolds, it...

2012-07-05 23:58:43

The findings have implications for the development of new anti-cancer drugs Scientists from the Florida campus of The Scripps Research Institute have identified a series of intricate biochemical steps that lead to the successful production of proteins, the basic working units of any cell. The study, which appears in the July 6, 2012 edition of the journal Cell, sheds light on the assembly of a structure called the ribosome, a large and complex protein-producing machine inside all living...

The Key To Self-renewing Skin
2012-07-05 13:45:19

In the July 6 issue of Cell Stem Cell, researchers at the University of California, San Diego School of Medicine describe how human epidermal progenitor cells and stem cells control transcription factors to avoid premature differentiation, preserving their ability to produce new skin cells throughout life. The findings provide new insights into the role and importance of exosomes and their targeted gene transcripts, and may help point the way to new drugs or therapies for not just skin...

2012-05-21 10:24:08

BRANFORD, Conn., May 21, 2012 /PRNewswire/ -- HistoRx, the leader in quantitative immunohistochemistry, announces the application of their proprietary AQUA technology to assessment of messenger RNA in tissue. AQUA technology enables robust quantification and standardization of protein in tissue specimens; this new work extends the platform's capabilities beyond protein expression analysis to quantification of nucleic acids. AQUA technology was invented to address the challenges of...