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Latest Messenger RNA Stories

2011-08-08 06:33:24

Comprehensive set of mutated mouse microRNAs will drive research A new resource to define the roles of microRNAs is announced today in Nature Biotechnology. The resource, called mirKO, gives researchers access to tools to investigate the biological role and significance for human health of these enigmatic genes. mirKO is a "library" of mutant mouse embryonic stem (ES) cells in which individual, or clustered groups of microRNA genes, have been deleted. Using these tools researchers can create...

2011-08-05 12:56:16

Italian researchers may have identified a genetic "signature" for dangerous plaque that leads to stroke. Reporting from their study published in Stroke: Journal of the American Heart Association, the researchers said a pattern of five microscopic bits of genetic material called microRNAs (miRNAs) "” a genetic "signature" "” were present only in the plaque from patients who had experienced a stroke. This is the first report to suggest that miRNAs may provide an important clue about...

2011-07-14 15:05:40

How the protein U2AF builds mRNA for protein production Scientists at the Technical University of Munich and the Helmholtz Zentrum Muenchen and along with their colleagues from the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Centre for Genomic Regulation in Barcelona have discovered how the U2AF protein enables the pre-mRNA* to be spliced to form the mRNA*, which serves as a template for protein synthesis in the body. Splicing requires the cooperation of different...

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2011-07-04 11:00:06

Whenever it hears an unfamiliar song from a male of the same species, the zebra finch stops chirping, hopping and grooming. It listens attentively for minutes at a time, occasionally cocking its head but otherwise immobile. Once it becomes familiar with the song, it goes back to its busy routine. In a new study, researchers discovered that levels of microRNAs "“ short lengths of ribonucleic acid that appear to regulate protein production "“ go up or down in the songbird brain...

2011-06-28 20:36:50

Easily accessible starting point on messenger RNA increases protein formation Texts without spaces are not very legible, as they make it very difficult for the reader to identify where a word begins and where it ends. When genetic information in our cells is read and translated into proteins, the enzymes responsible for this task face a similar challenge. They must find the correct starting point for protein synthesis. Therefore, in organisms with no real nucleus, a point exists shortly...

2011-06-14 01:16:57

Many more hereditary diseases than previously thought may be caused, at least in part, by errors in pre-mRNA splicing, according to a computer analysis by Brown University scientists. That could be good news because research suggests it may be possible to fix bad splicing. A new Brown University computer analysis that predicts the effect of genetic mutations on how the body splices mRNA indicates as many as a third of disease-related mutations may be linked to splicing problems "” more...

2011-05-18 16:32:56

How do genes control us? This fundamental question of life still remains elusive despite decades of research. Genes are blueprints for proteins, but it is the proteins that actually carry out vital functions in the body for maintaining life. Diseases such as cancer are not only characterized by altered genes, but also by disturbed protein production. But how is protein production controlled? Researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch of the Helmholtz...

2011-04-21 23:02:28

Researchers at Albert Einstein College of Medicine of Yeshiva University have for the first time observed the activity of a single gene in living cells. In an unprecedented study, published in the April 22 online edition of Science, Einstein scientists were able to follow, in real time, the process of gene transcription, which occurs when a gene converts its DNA information into molecules of messenger RNA (mRNA) that go on to make the protein coded by the gene. Robert Singer, Ph.D.,...

2011-04-20 15:05:19

Intracellular transport mechanism dissected In a multicellular organism, different cells fulfill a range of diversified functions. Often such specialization depends on the delivery of molecular goods to distinct places within a cell. It ensures that particular functions only occur at defined cellular sites. This establishment of intracellular asymmetry in the otherwise fluid environment of the cell cytoplasm requires active transport processes. Messenger RNAs (mRNA) represent an especially...

2011-03-23 20:26:49

Noted experts explore this topic in the April issue of Translational Research Since their discovery in the 1990s, microRNAs have proven to play a complex role in normal and abnormal functioning of many organ systems. In the April issue of Translational Research, entitled "MicroRNAs: A Potential New Frontier for Medicine," an international group of medical experts explores several themes related to our current understanding of microRNAs and the role they may play in the future of medicine. A...