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Latest Messenger RNA Stories

2011-04-21 23:02:28

Researchers at Albert Einstein College of Medicine of Yeshiva University have for the first time observed the activity of a single gene in living cells. In an unprecedented study, published in the April 22 online edition of Science, Einstein scientists were able to follow, in real time, the process of gene transcription, which occurs when a gene converts its DNA information into molecules of messenger RNA (mRNA) that go on to make the protein coded by the gene. Robert Singer, Ph.D.,...

2011-04-20 15:05:19

Intracellular transport mechanism dissected In a multicellular organism, different cells fulfill a range of diversified functions. Often such specialization depends on the delivery of molecular goods to distinct places within a cell. It ensures that particular functions only occur at defined cellular sites. This establishment of intracellular asymmetry in the otherwise fluid environment of the cell cytoplasm requires active transport processes. Messenger RNAs (mRNA) represent an especially...

2011-03-23 20:26:49

Noted experts explore this topic in the April issue of Translational Research Since their discovery in the 1990s, microRNAs have proven to play a complex role in normal and abnormal functioning of many organ systems. In the April issue of Translational Research, entitled "MicroRNAs: A Potential New Frontier for Medicine," an international group of medical experts explores several themes related to our current understanding of microRNAs and the role they may play in the future of medicine. A...

2011-03-21 16:04:18

    * Tiny Locked Nucleic Acid (LNA) based compounds, which are 8-mer LNA oligonucleotides, successfully inhibit entire microRNA families, providing potential new approach for treating a variety of diseases, including cancer, viral infections, cardiovascular and muscle diseases     * Data show high affinity and target specificity of tiny LNA-based compounds enabled functional inhibition of entire microRNA families in a range of tissues without off-target effects...

2011-03-15 05:00:00

REDWOOD CITY, Calif., March 15, 2011 - Ingenuity® Systems, a leading provider of information and analytics solutions for life science researchers, today announced new features to support RNA-Sequencing workflows and microRNA research in IPA®. Processed RNA-Seq datasets can now be uploaded directly into IPA and analyzed in the context of pathways and diseases for a rich biological interpretation of the data. This helps researchers quickly and accurately...

2011-03-10 23:36:25

Lasers used to study splicing of pre-messenger RNA molecules From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950's. Now, with the work being done in Jeff Gelles' Lab at Brandeis University, researchers have developed a way to use lasers to study the splicing of pre-messenger RNA molecules, an essential process in creating proteins to sustain advanced organisms, including human life. This process of splicing...

2011-03-09 16:02:28

Scientists at the University of Pennsylvania explain how a class of RNA molecules is able to target the genetic building blocks that guide the functioning of a specific part of the nerve cell. Abnormalities at this site are in involved in epilepsy, neurodegenerative disease, and cognitive disorders. Their results are published this week in the journal Neuron. A team of researchers, led by James Eberwine, PhD, the Elmer Bobst Professor of Pharmacology in the School of Medicine, and Junhyong...

2011-02-09 23:47:18

Study finds long-known, but little-understood DNA elements serve important purpose Scientists have discovered a new way genes are regulated that is unique to primates, including humans and monkeys. Though the human genome "“ all the genes that an individual possesses "“ was sequenced 10 years ago, greater understanding of how genes function and are regulated is needed to make advances in medicine, including changing the way we diagnose, treat and prevent a wide range of diseases....

2011-02-07 18:21:16

Defects in the genome are the cause of many diseases. Gene therapy "“ direct replacement of mutant genes by intact DNA copies "“ offers a means of correcting such defects. Now a research team based at the Medical Center of the University of Munich, and led by Privatdozent Dr. Carsten Rudolph, has taken a new approach that avoids DNA delivery. The team shows for the first time that chemical modification of mRNAs (the metabolically active molecules derived from genomic DNA that...

2011-01-25 12:50:20

MicroRNAs (miRNAs) regulate gene expression by mainly binding to the 3"²-UTR of target mRNAs, leading to mRNA degradation or translation inhibition. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China. Many studies have reported the miRNA expression profiles in Barrett's esophagus and esophageal adenocarcinoma. However, the pathobiological significance of aberrant miRNA expression in human ESCC has not been well documented. A research article to be...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.