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Last updated on April 21, 2014 at 8:55 EDT

Latest Metabotropic glutamate receptor Stories

Detailed Picture Of Protein Linked To Learning, Pain And Brain Disorders Created By Scientists
2014-03-07 11:26:29

Scripps Research Institute Researchers at The Scripps Research Institute (TSRI) and Vanderbilt University have created the most detailed 3-D picture yet of a membrane protein that is linked to learning, memory, anxiety, pain and brain disorders such as schizophrenia, Parkinson's, Alzheimer's and autism. "This receptor family is an exciting new target for future medicines for treatment of brain disorders," said P. Jeffrey Conn, PhD, Lee E. Limbird Professor of Pharmacology and director...

2012-11-30 11:53:28

Findings from a new study in Biological Psychiatry A potential new therapeutic strategy for treating Fragile X syndrome is detailed in a new report appearing in the current issue of Biological Psychiatry, from researchers led by Dr. Lucia Ciranna at University of Catania in Italy. Fragile X syndrome (FXS), the most common heritable form of autism and intellectual disability, is one of the most exciting areas in brain research at the moment. A decade ago, Dr. Mark Bear and his...

2012-04-24 22:20:57

WELWYN GARDEN CITY, England and BOSTON, April 25, 2012 /PRNewswire/ -- Review published in Trends in Pharmacological Sciences Heptares Therapeutics, the leading GPCR drug discovery company, announces the recent publication of a major review of the state of the art for GPCR drug discovery and new insights that, for the first time, can be obtained from structural biology. The review has been published online in Trends in Pharmacological Sciences, a Cell...

2011-10-19 20:20:33

OPHN1 is found to be essential for mGluR-dependent long-term depression at synapses Scientists at Cold Spring Harbor Laboratory (CSHL) have solved part of a puzzle concerning the relationship between changes in the strength of synapses — the tiny gaps across which nerve cells in the brain communicate — and dysfunctions in neural circuits that have been linked with drug addiction, mental retardation and other cognitive disorders. A team led by CSHL Professor Linda Van Aelst...

2011-10-17 05:00:00

DALLAS, October 17, 2011 /PRNewswire/ -- This research report 'Depression Therapeutics - Pipeline Assessment and Market Forecasts to 2018' valued the global depression therapeutics market at $4.6 billion in 2010, and expects it to grow at a compound annual growth rate (CAGR) of 3.2% over the next seven years to reach $10.9 billion by 2018. The depression therapeutics market...

2010-08-10 15:44:11

The authors of a new study in Biological Psychiatry explore pharmacological strategies for reducing cocaine self-administration in animals that may have implications for treating cocaine dependence in humans. Glutamate is the primary excitatory neurotransmitter in the brain, which has been implicated in drug addiction. Metabotropic glutamate receptors (mGluRs) represent a family of G-protein coupled receptors that modulate glutamate transmission. Glutamate is an important neurotransmitter...

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2010-07-16 10:32:22

Penn Researchers Reverse Cognitive Decline in Flies With Alzheimer's Gene Mutation Investigators have found that fruit fly (Drosophila melanogaster)  males -- in which the activity of an Alzheimer's disease protein is reduced by 50 percent -- show impairments in learning and memory as they age. What's more, the researchers were able to prevent the age-related deficits by treating the flies with drugs such as lithium, or by genetic manipulations that reduced nerve-cell signaling. The...

2010-06-08 12:30:24

Researchers at India's National Centre for Biological Sciences (NCBS) and New York University's Center for Neural Science have identified novel synaptic defects in an area of the brain that is involved in the debilitating emotional symptoms of Fragile X Syndrome (FXS). FXS is the leading known genetic cause of autism and mental retardation. The study, which appears in the journal the Proceedings of the National Academy of Sciences, is also of potential therapeutic significance"”it...

2010-02-23 14:25:00

Huntington's disease (HD) is a cruel, hereditary condition that leads to severe physical and mental deterioration, psychiatric problems and eventually, death. Currently, there are no treatments to slow down or stop it. HD sufferers are born with the disease although they do not show symptoms until late in life. In a new study published in The Journal of Neuroscience, Stephen Ferguson and Fabiola Ribeiro of Robarts Research Institute at The University of Western Ontario identified a protective...

2009-10-19 17:53:22

Glutamate is to the brain like coffee is to our bodies. A cup of Joe in the morning can wake us, but overloading on caffeine causes the stimulant to work against us. Glutamate is the major excitatory neurotransmitter in a mammal's central nervous system. It is an important component for neuroplasticity, the synaptic communication between neurons. It's also key to learning and memory. But in high concentrations, glutamate becomes toxic-- over-exciting the neurons. Glutamate-induced...