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Latest Metalloproteins Stories

2013-10-31 10:34:32

University of Notre Dame researchers have, for the first time, identified the enzymes that are detrimental to diabetic wound healing and those that are beneficial to repair the wound. There are currently no therapeutics for diabetic wound healing. The current standard of care is palliative to keep the wound clean and free of infection. In the United States, 66,000 diabetic individuals each year undergo lower-limb amputations due to wounds that failed to heal. A team of researchers from...

2013-05-24 13:51:24

UEA scientists make breast cancer advance that turns previous thinking on its head Scientists at the University of East Anglia have made an advance in breast cancer research which shows how some enzymes released by cancerous cells could have a protective function. New research published today in the Journal of Biological Chemistry reveals that an enzyme called MMP-8 (matrix metalloproteinase-8) could be acting as a locator to the immune system, which then becomes activated to attack...

2011-12-26 07:23:28

A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine. Prof. Irit Sagi of the Biological Regulation Department and her...

2011-06-30 05:30:00

SALT LAKE CITY, June 30, 2011 /PRNewswire/ -- LifeVantage Corporation (OTCBB: LFVN), the maker of science-based solutions for the reduction of oxidative stress by the synergistic activation of Nrf2, announced today that renowned scientist, co-discoverer of superoxide dismutase and a pioneer in the area of Free Radical Biology, Dr. Joe M. McCord, has accepted the position as the Company's Chief Scientific Officer. In addition, Dr. Brooks Hybertson, nationally-recognized oxidative stress...

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2010-07-20 08:59:58

New method could lead to innovative clean energy and bioremediation technologies, and help explain how microbes shape Earth's climate A new way of surveying microbes for the metals they contain reveals that biologists have been relying on the equivalent of a 15th century map of the world. It turns out that there are many more metal-containing proteins in microbes than previously recognized. This means the microbial world boasts a broader and more diverse array of metal-driven chemical...

2009-11-04 14:42:11

New insight into how nature handles some fundamental processes is guiding researchers in the design of tailor-made proteins for applications such as artificial photosynthetic centers, long-range electron transfers, and fuel-cell catalysts for energy conversion. From rusting iron to forest fires to the beating of a human heart, oxidation-reduction reactions, which transfer electrons from one atom to another, are at the heart of many chemical and biological processes. Each process requires a...

2009-07-23 08:45:51

A group led by Dr. Yasunori Okada at Keio University in Tokyo, Japan has demonstrated that matrix metalloproteinases (MMPs) are instrumental in wound healing. Their report can be found in the August 2009 issue of The American Journal of Pathology.Wound healing is the complex process of regenerating dermal and epidermal tissue after skin injury. MMPs, which can degrade proteins, are essential in breaking down wounded tissues to allow for wound healing; however, the specific function of...

2009-05-13 08:17:53

Arthropods and mollusks are Nature's true bluebloods "“ thanks to hemocyanin, an oxygen-carrying large protein complex, which can even be turned into the enzymatically active chemical phenoloxidase. Scientists have long known that members of the phenoloxidase family are involved in skin and hair coloring. When they are mutated, they can cause albinism "“ the loss of coloring in skin and hair. Produced over abundantly, they are associated with the deadly skin cancer melanoma. In an...

2009-02-18 09:08:58

When a promising cancer drug reached clinical trials in the 1990s, researchers were disappointed by the debilitating side effects that limited the trials. The drug inhibited a family of enzymes known as matrix metalloproteinases (MMPs). Now, researchers at Rensselaer Polytechnic Institute have shown that creating drugs that inactivate a different part of the MMP enzyme could have the capacity to target the tumor without the damaging side effects. Their findings, which hold promise for...

2008-07-25 03:00:40

By Kubiak, Karina Nowak, Wieslaw ABSTRACT Nitrile hydratase (NHase) is an enzyme used in the industrial biotechnological production of acrylamide. The active site, which contains nonheme iron or noncorrin cobalt, is buried in the protein core at the interface of two domains, alpha and beta. Hydrogen bonds between betaArg-56 and alphaCys-114 sulfenic acid (alphaCEA114) are important to maintain the enzymatic activity. The enzyme may be inactivated by endogenous nitric oxide (NO) and...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.