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New Technique Maps Lifes Effects On Our DNA

New Technique Maps Life's Effects On Our DNA

Biotechnology and Biological Sciences Research Council (BBSRC) Researchers develop new, powerful single-cell technique to study environmental effects on DNA Researchers at the BBSRC-funded Babraham Institute, in collaboration with the...

Latest Methylation Stories

2014-07-28 10:39:26

Baylor College of Medicine Cancer has long been thought to be primarily a genetic disease, but in recent decades scientists have come to believe that epigenetic changes – which don't change the DNA sequence but how it is 'read' – also play a role in cancer. In particular DNA methylation, the addition of a methyl group (or molecule), is an epigenetic switch that can stably turn off genes, suggesting the potential to cause cancer just as a genetic mutation can. Until now, however,...

2014-07-11 10:58:16

University of Cambridge When a pregnant mother is undernourished, her child is at a greater than average risk of developing obesity and type 2 diabetes, in part due to so-called 'epigenetic' effects. A new study in mice demonstrates that this 'memory' of nutrition during pregnancy can be passed through sperm of male offspring to the next generation, increasing risk of disease for her grandchildren as well. In other words, to adapt an old maxim, 'you are what your grandmother ate'. The...

2014-05-29 10:36:33

Emory Health Sciences DNA methylation critical in model of atherosclerosis Disturbed patterns of blood flow induce lasting epigenetic changes to genes in the cells that line blood vessels, and those changes contribute to atherosclerosis, researchers have found. The findings suggest why the protective effects of good blood flow patterns, which aerobic exercise promotes, can persist over time. An epigenetic change to DNA is a chemical modification that alters whether nearby genes are...

2014-04-11 10:21:24

ZMYND11 'reads' methylated variant to thwart cancer; tied to breast cancer patient survival A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014. The findings, also published in the journal Nature on April 10, provide evidence in...

2014-04-10 14:53:02

In 10% of human tumors there is a family history of hereditary disease associated with mutations in identified genes. The best examples are the cases of polyps in the large intestine associated with the APC gene and breast cancer associated with BRCA1 and BRCA2 genes. In the remaining 90% of cases are believed to have an increased risk of developing cancer in relation to genetic variants less powerful but more often, for example, doubles the risk of having a tumor that lacks this small...

2014-04-08 11:51:42

From time to time, living cells will accidentally make an extra copy of a gene during the normal replication process. Throughout the history of life, evolution has molded some of these seemingly superfluous genes into a source of genetic novelty, adaptation and diversity. A new study shows one way that some duplicate genes could have long-ago escaped elimination from the genome, leading to the genetic innovation seen in modern life. Researchers have shown that a process called DNA...

2014-04-04 23:35:33

Xtalks presents an informative webinar that will examine the development of flexible targeted bisulfite sequencing tool and how it has been applied in methylation research, on Tuesday, April 29, 2014 at 12:00 EDT. Toronto, Canada (PRWEB) April 03, 2014 Epigenetic researchers face a number of challenges in methylation studies related to breadth, depth, throughput and more. Built on Roche NimbleGen’s proprietary probe design and manufacturing technologies, the SeqCap Epi Enrichment System...

2014-04-01 15:23:26

New research in The FASEB Journal suggests that molecular function of the "hairless" gene may explain why mutations contribute to the pathogenesis of atrichia with papular lesions, a rare form of hair loss It's not a hair-brained idea: A new research report appearing in the April 2014 issue of The FASEB Journal explains why people with a rare balding condition called "atrichia with papular lesions" lose their hair, and it identifies a strategy for reversing this hair loss. Specifically the...

2014-02-07 23:04:16

Xtalks presents a new and informative webinar that focuses on epigenetics research to understand DNA methylation changes that occur within lineage-specific and cancer-specific chromatin states. The live webinar takes place on Wednesday, February 26, 2014 at 2pm EST (7pm GMT). Toronto, Canada (PRWEB) February 07, 2014 Transcriptional regulation is accomplished by both focal cis-regulatory elements (promoters, enhancers, and insulators) and the higher order organization of chromosomes...

Environment, Lifestyle Factors Determines Changes In Pain Sensitivity
2014-02-05 09:12:41

Ranjini Raghunath for redOrbit.com - Your Universe Online The way you react to pain keeps changing throughout your lifetime, influenced by lifestyle and environmental factors, a new study carried out by researchers at King’s College London suggests. The study identified genetic changes that determine how different people – even identical twins -- react to pain differently. The results from the study could help scientists understand how pain sensitivity differs in individuals, and...


Word of the Day
toccata
  • In music, a work for a keyboard-instrument, like the pianoforte or organ, originally intended to utilize and display varieties of touch: but the term has been extended so as to include many irregular works, similar to the prelude, the fantasia, and the improvisation.
This word is Italian in origin, coming from the feminine past participle of 'toccare,' to touch.
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