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Last updated on April 17, 2014 at 1:21 EDT

Latest Methylation Stories

2014-04-11 10:21:24

ZMYND11 'reads' methylated variant to thwart cancer; tied to breast cancer patient survival A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014. The findings, also published in the journal Nature on April 10, provide evidence in...

2014-04-10 14:53:02

In 10% of human tumors there is a family history of hereditary disease associated with mutations in identified genes. The best examples are the cases of polyps in the large intestine associated with the APC gene and breast cancer associated with BRCA1 and BRCA2 genes. In the remaining 90% of cases are believed to have an increased risk of developing cancer in relation to genetic variants less powerful but more often, for example, doubles the risk of having a tumor that lacks this small...

2014-04-08 11:51:42

From time to time, living cells will accidentally make an extra copy of a gene during the normal replication process. Throughout the history of life, evolution has molded some of these seemingly superfluous genes into a source of genetic novelty, adaptation and diversity. A new study shows one way that some duplicate genes could have long-ago escaped elimination from the genome, leading to the genetic innovation seen in modern life. Researchers have shown that a process called DNA...

2014-04-04 23:35:33

Xtalks presents an informative webinar that will examine the development of flexible targeted bisulfite sequencing tool and how it has been applied in methylation research, on Tuesday, April 29, 2014 at 12:00 EDT. Toronto, Canada (PRWEB) April 03, 2014 Epigenetic researchers face a number of challenges in methylation studies related to breadth, depth, throughput and more. Built on Roche NimbleGen’s proprietary probe design and manufacturing technologies, the SeqCap Epi Enrichment System...

2014-04-01 15:23:26

New research in The FASEB Journal suggests that molecular function of the "hairless" gene may explain why mutations contribute to the pathogenesis of atrichia with papular lesions, a rare form of hair loss It's not a hair-brained idea: A new research report appearing in the April 2014 issue of The FASEB Journal explains why people with a rare balding condition called "atrichia with papular lesions" lose their hair, and it identifies a strategy for reversing this hair loss. Specifically the...

2014-02-07 23:04:16

Xtalks presents a new and informative webinar that focuses on epigenetics research to understand DNA methylation changes that occur within lineage-specific and cancer-specific chromatin states. The live webinar takes place on Wednesday, February 26, 2014 at 2pm EST (7pm GMT). Toronto, Canada (PRWEB) February 07, 2014 Transcriptional regulation is accomplished by both focal cis-regulatory elements (promoters, enhancers, and insulators) and the higher order organization of chromosomes...

Environment, Lifestyle Factors Determines Changes In Pain Sensitivity
2014-02-05 09:12:41

Ranjini Raghunath for redOrbit.com - Your Universe Online The way you react to pain keeps changing throughout your lifetime, influenced by lifestyle and environmental factors, a new study carried out by researchers at King’s College London suggests. The study identified genetic changes that determine how different people – even identical twins -- react to pain differently. The results from the study could help scientists understand how pain sensitivity differs in individuals, and...

DNA Methylation May Increase Cancer Risk As We Age
2014-02-04 05:01:25

redOrbit Staff & Wire Reports - Your Universe Online Age-related changes in a biochemical process known as DNA methylation could be responsible for the increased risk of cancer in older men and women, according to research appearing in the latest edition of the journal Carcinogenesis. While medical experts have long known that the aging process is a leading risk factor for the development of several different types of cancer, the exact reasons for that phenomenon have remained...

2014-01-28 12:29:40

-- Bird identified DNA regions where genes are activated, a fundamental contribution in the field of epigenetics, which studies how environmental factors influence diseases such as cancer MADRID, Jan. 28, 2014 /PRNewswire/ -- The sixth annual BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category goes to British biochemist Adrian Bird, "for his discoveries in the field of epigenetics." Bird's achievements includes mapping DNA regions where genes are activated by...

2014-01-16 14:30:04

Application of global sequencing technology reveals how an activator of gene expression stays focused At a glance, DNA is a rather simple sequence of A, G, C, T bases, but once it is packaged by histone proteins into an amalgam called chromatin, a more complex picture emerges. Histones, which come in four subtypes—H2A, H2B, H3, and H4—can either coil DNA into inaccessible silent regions or untwist it to allow gene expression. To further complicate things, small chemical flags, such as...