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Latest Methylation Stories

2011-05-18 14:18:29

Children whose mothers or grandmothers smoked during pregnancy are at increased risk of asthma in childhood, but the underlying causes of this are not well understood. Now a new study indicates changes in a process called DNA methylation that occurs before birth may be a root cause. The study will be presented at the ATS 2011 International Conference. DNA methylation is a process that can alter a gene's usual function. These altered genes can be passed along from parent to child. In this...

2011-05-12 22:14:40

Discovery, which has implications for cancer, explains why some genes are silenced Japanese and U.S. scientists in the young field of epigenetics Thursday reported a rationale as to how specific genes are silenced and others are not. Because this effect can be reversed, it may be possible to devise therapies for cancer and other diseases using this information. The NOVA U.S. public television program described epigenetics as "The Ghost In Your Genes." It is the study of changes in gene...

2011-05-02 16:30:51

Mayo Clinic researchers have discovered two mutations responsible for a devastating neurological condition they first identified 15 years ago. The researchers say their study -- appearing in Nature Genetics -- has revealed a new neural pathway that may help understand a variety of similar conditions. "We were able to do this now because of Next Generation genomic sequencing technology," says Christopher Klein, M.D., Mayo Clinic neurologist and lead author of the study. "We also had the...

2011-04-20 21:26:46

Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life, researchers at the University at Buffalo have shown. The findings indicated that higher air pollution exposure at birth may alter DNA methylation, which may increase levels of E-cadherin, a protein important to the adhesion of cells, a function that plays an essential role in maintaining a stable cellular environment...

2011-04-15 00:00:28

BellBrook Labs has developed a new HTS assay for screening methyltransferases, the family of enzymes involved in epigenetic modifications that cause cancerous cell growth and metastasis. The innovative EPIGEN Methyltransferase Assay combines proprietary coupling enzymes with the detection module of the extensively validated Transcreener® HTS Assay platform to advance the discovery of new anti-cancer therapeutics. Madison, WI (PRWEB) April 14, 2011 BellBrook Labs today introduced an...

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2011-04-11 07:58:23

A newly sequenced bacterial genome from a team led by the Department of Energy's Oak Ridge National Laboratory (ORNL) could contain clues as to how microorganisms produce a highly toxic form of mercury. Methylmercury, a potent human neurotoxin, appears in the environment when certain naturally occurring bacteria transform inorganic mercury into its more toxic cousin. Few bacterial species are capable of this conversion, and exactly how the transformation takes place has been a matter of...

2011-04-08 07:00:00

SAN DIEGO, April 8, 2011 /PRNewswire/ -- Polaris Group (Polaris) announced today that data from preclinical studies suggest ADI-PEG 20, the Company's pegylated arginine deiminase therapeutic, may be effective in treating acute myeloid leukemia (AML), glioblastoma multiforme (GBM) and bladder cancer. These cancers have a high incidence of deficiencies of the arginine synthesis enzyme argininosuccinate synthetase (ASS) due to hypermethylation at the promoter of the gene that codes for ASS...

2011-04-05 15:15:00

IPSWICH, Mass. and SAN DIEGO, April 5, 2011 /PRNewswire/ -- New England Biolabs, Inc. (NEB) and Sequenom, Inc. (NASDAQ: SQNM) jointly announce that they have signed a licensing and co-marketing agreement to commercialize research tools for epigenetics. This agreement is the result of a research collaboration between the two companies that has culminated in the development of the EpiMark(TM) Methylated DNA Enrichment Kit from NEB. (Logo:...

2011-03-23 15:45:01

Tel Aviv University researcher warns that it isn't 'all in the genes' When the Human Genome Project ended a decade ago, scientists thought that they'd closed the lid on all that's to be known about our genes. But what they really did was open a Pandora's Box, says theoretical evolutionary biologist Prof. Eva Jablonka of Tel Aviv University's Cohn Institute for the History and Philosophy of Science and Ideas. After sifting through hundreds of scientific studies concerned with epigenetics,...

2011-02-25 08:42:21

By Rhonda Craig, Ivanhoe Health Correspondent (Ivanhoe Newswire) -- A blood test may be able to accurately detect markers of bladder cancer. A new study shows that cancer associated with a specific methylation pattern (a chemical alteration to DNA that affects which genes are expressed in cells) can readily be detected in the blood. Since it's not possible to document and assess all of the carcinogenic exposures a person has had in life, researchers hoped to find a more precise way to predict...


Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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