Quantcast
Last updated on April 23, 2014 at 13:36 EDT

Latest Methylation Stories

2011-02-01 17:27:44

Think of your genome as a dynamic outdoor sculpture. Its shape is, of course, influenced by its structural underpinnings "“ the double helix containing phosphate and two chains of nucleotides attached to a sugar called deoxyribose. These chains wind around each other, linked by hydrogen bonds between the specific bases "“ adenine to thymine and cytosine to guanine. But forces outside your sculpture also act on it. If it were really outside, the forces would be wind, rain, sunlight...

2011-01-03 21:04:33

Tagging an enzyme with chemical also is crucial to bone cell formation By sticking a chemical group to it at a specific site, a protein arrests an enzyme that may worsen and spread cancer, an international research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the January issue of Nature Cell Biology. In addition to highlighting a novel anti-cancer pathway, the team found that the same deactivation of the enzyme called EZH2 is necessary for the...

2011-01-03 08:24:20

(Ivanhoe Newswire) "“ New insight into the biology of many kinds of less aggressive but lethal brain tumors, or gliomas, opens up a wide variety of possibilities for new therapies, according to this study. The researchers describe how genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers."What this tells you is that there are some forms of tumors with a fundamentally altered process," Karl Kelsey, a professor of pathology and...

2010-12-31 12:21:01

(Ivanhoe Newswire) "“ Many mechanisms change the activity of genes. Epigenetics determine when genes are turned on and off, and these epigenetics allow for cells to become cancerous. This was especially seen in ovarian cancer. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological signaling pathway in particular was found to contain many genes influenced by DNA methylation, a mechanism...

2010-12-23 17:18:28

Study examines effects of supplementation, other factors, on gene methylation People with higher levels of folate in their red blood cells were more likely to have two tumor-suppressing genes shut down by methylation, a chemical off switch for genes, researchers report in the December issue of Cancer Prevention Research. DNA hypermethylation, notes co-author Jean-Pierre Issa, M.D., professor in MD Anderson's Department of Leukemia, is found in a variety of cancers and diseases of aging, such...

2010-12-16 13:18:15

A newly published insight into the biology of many kinds of less-aggressive but still lethal brain tumors, or gliomas, opens up a wide array of possibilities for new therapies, according to scientists at Brown University and the University of California, San Francisco (UCSF). In paper published online Dec. 15 in the Journal of the National Cancer Institute, they describe how a genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers. "What...

2010-12-14 14:55:49

Ovarian cancer is the leading cause of death among gynecological cancers. To better understand the disease and improve therapies, researchers are investigating how deregulation of genes across the genome could be contributing to malignancy. In a study published online today in Genome Research (www.genome.org), scientists have identified age-related gene-specific accumulation of DNA methylation that suppresses a critical cellular pathway contributing to ovarian carcinogenesis, information that...

2010-12-14 14:36:37

There are many mechanisms that alter the activity of genes "“ direct changes to the DNA code like mutations and deletions, or changes that control when genes are switched on and off, called epigenetic means. Tumor-suppressor genes are often inactivated through epigenetics, which provides an opening for the cancerous growth of cells. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological...

2010-12-13 13:46:28

Researchers at Emory University School of Medicine and the University of Chicago have developed a method for labeling and mapping a "sixth nucleotide," whose biological role scientists are only beginning to explore. The method is described online this week in Nature Biotechnology. The method allowed the researchers to see for the first time how 5-hydroxymethylcytosine (5-hmC) is distributed throughout the genome. Unlike 5-methylcytosine (5-mC), a chemical modification of DNA that is generally...

09f9bbb1091b94c3a60005a3797e3b5d1
2010-11-11 10:32:03

Scientists have observed, for the first time, an intermediate stage in the chemical process that repairs DNA methylation damage and regulates many important biological functions that impact health conditions such as obesity, cancer and diabetes. The observations focused on the bacterial DNA repair protein AlkB, but the results also apply to several proteins in the same family that play key regulatory roles in humans. Armed with these results, researchers may one day develop methods for...