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Latest Methylation Stories

2011-04-20 21:26:46

Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life, researchers at the University at Buffalo have shown. The findings indicated that higher air pollution exposure at birth may alter DNA methylation, which may increase levels of E-cadherin, a protein important to the adhesion of cells, a function that plays an essential role in maintaining a stable cellular environment...

2011-04-15 00:00:28

BellBrook Labs has developed a new HTS assay for screening methyltransferases, the family of enzymes involved in epigenetic modifications that cause cancerous cell growth and metastasis. The innovative EPIGEN Methyltransferase Assay combines proprietary coupling enzymes with the detection module of the extensively validated Transcreener® HTS Assay platform to advance the discovery of new anti-cancer therapeutics. Madison, WI (PRWEB) April 14, 2011 BellBrook Labs today introduced an...

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2011-04-11 07:58:23

A newly sequenced bacterial genome from a team led by the Department of Energy's Oak Ridge National Laboratory (ORNL) could contain clues as to how microorganisms produce a highly toxic form of mercury. Methylmercury, a potent human neurotoxin, appears in the environment when certain naturally occurring bacteria transform inorganic mercury into its more toxic cousin. Few bacterial species are capable of this conversion, and exactly how the transformation takes place has been a matter of...

2011-04-08 07:00:00

SAN DIEGO, April 8, 2011 /PRNewswire/ -- Polaris Group (Polaris) announced today that data from preclinical studies suggest ADI-PEG 20, the Company's pegylated arginine deiminase therapeutic, may be effective in treating acute myeloid leukemia (AML), glioblastoma multiforme (GBM) and bladder cancer. These cancers have a high incidence of deficiencies of the arginine synthesis enzyme argininosuccinate synthetase (ASS) due to hypermethylation at the promoter of the gene that codes for ASS...

2011-04-05 15:15:00

IPSWICH, Mass. and SAN DIEGO, April 5, 2011 /PRNewswire/ -- New England Biolabs, Inc. (NEB) and Sequenom, Inc. (NASDAQ: SQNM) jointly announce that they have signed a licensing and co-marketing agreement to commercialize research tools for epigenetics. This agreement is the result of a research collaboration between the two companies that has culminated in the development of the EpiMark(TM) Methylated DNA Enrichment Kit from NEB. (Logo:...

2011-03-23 15:45:01

Tel Aviv University researcher warns that it isn't 'all in the genes' When the Human Genome Project ended a decade ago, scientists thought that they'd closed the lid on all that's to be known about our genes. But what they really did was open a Pandora's Box, says theoretical evolutionary biologist Prof. Eva Jablonka of Tel Aviv University's Cohn Institute for the History and Philosophy of Science and Ideas. After sifting through hundreds of scientific studies concerned with epigenetics,...

2011-02-25 08:42:21

By Rhonda Craig, Ivanhoe Health Correspondent (Ivanhoe Newswire) -- A blood test may be able to accurately detect markers of bladder cancer. A new study shows that cancer associated with a specific methylation pattern (a chemical alteration to DNA that affects which genes are expressed in cells) can readily be detected in the blood. Since it's not possible to document and assess all of the carcinogenic exposures a person has had in life, researchers hoped to find a more precise way to predict...

2011-02-02 20:32:41

Reprogramming adult cells to recapture their youthful "can-do-it-all" attitude appears to leave an indelible mark, found researchers at the Salk Institute for Biological Studies. When the team, led by Joseph Ecker, PhD., a professor in the Genomic Analysis Laboratory, scoured the epigenomes of so-called induced pluripotent stem cells base by base, they found a consistent pattern of reprogramming errors. What's more, these incompletely or inadequately reprogrammed hotspots are maintained when...

2011-02-01 17:27:44

Think of your genome as a dynamic outdoor sculpture. Its shape is, of course, influenced by its structural underpinnings "“ the double helix containing phosphate and two chains of nucleotides attached to a sugar called deoxyribose. These chains wind around each other, linked by hydrogen bonds between the specific bases "“ adenine to thymine and cytosine to guanine. But forces outside your sculpture also act on it. If it were really outside, the forces would be wind, rain, sunlight...

2011-01-03 21:04:33

Tagging an enzyme with chemical also is crucial to bone cell formation By sticking a chemical group to it at a specific site, a protein arrests an enzyme that may worsen and spread cancer, an international research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the January issue of Nature Cell Biology. In addition to highlighting a novel anti-cancer pathway, the team found that the same deactivation of the enzyme called EZH2 is necessary for the...


Word of the Day
barghest
  • A goblin in English folklore, often appearing in the shape of a large dog and believed to portend imminent death or misfortune.
  • A ghost, wraith, hobgoblin, elf, or spirit.
The origin of 'barghest' is not known, but it may be from perhaps burh-ghest, town-ghost, or German Berg-geist (mountain spirit) or Bär-geist (bear-spirit).
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