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Latest Methylation Stories

2011-02-25 08:42:21

By Rhonda Craig, Ivanhoe Health Correspondent (Ivanhoe Newswire) -- A blood test may be able to accurately detect markers of bladder cancer. A new study shows that cancer associated with a specific methylation pattern (a chemical alteration to DNA that affects which genes are expressed in cells) can readily be detected in the blood. Since it's not possible to document and assess all of the carcinogenic exposures a person has had in life, researchers hoped to find a more precise way to predict...

2011-02-02 20:32:41

Reprogramming adult cells to recapture their youthful "can-do-it-all" attitude appears to leave an indelible mark, found researchers at the Salk Institute for Biological Studies. When the team, led by Joseph Ecker, PhD., a professor in the Genomic Analysis Laboratory, scoured the epigenomes of so-called induced pluripotent stem cells base by base, they found a consistent pattern of reprogramming errors. What's more, these incompletely or inadequately reprogrammed hotspots are maintained when...

2011-02-01 17:27:44

Think of your genome as a dynamic outdoor sculpture. Its shape is, of course, influenced by its structural underpinnings "“ the double helix containing phosphate and two chains of nucleotides attached to a sugar called deoxyribose. These chains wind around each other, linked by hydrogen bonds between the specific bases "“ adenine to thymine and cytosine to guanine. But forces outside your sculpture also act on it. If it were really outside, the forces would be wind, rain, sunlight...

2011-01-03 21:04:33

Tagging an enzyme with chemical also is crucial to bone cell formation By sticking a chemical group to it at a specific site, a protein arrests an enzyme that may worsen and spread cancer, an international research team led by scientists at The University of Texas MD Anderson Cancer Center reports in the January issue of Nature Cell Biology. In addition to highlighting a novel anti-cancer pathway, the team found that the same deactivation of the enzyme called EZH2 is necessary for the...

2011-01-03 08:24:20

(Ivanhoe Newswire) "“ New insight into the biology of many kinds of less aggressive but lethal brain tumors, or gliomas, opens up a wide variety of possibilities for new therapies, according to this study. The researchers describe how genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers."What this tells you is that there are some forms of tumors with a fundamentally altered process," Karl Kelsey, a professor of pathology and...

2010-12-31 12:21:01

(Ivanhoe Newswire) "“ Many mechanisms change the activity of genes. Epigenetics determine when genes are turned on and off, and these epigenetics allow for cells to become cancerous. This was especially seen in ovarian cancer. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological signaling pathway in particular was found to contain many genes influenced by DNA methylation, a mechanism...

2010-12-23 17:18:28

Study examines effects of supplementation, other factors, on gene methylation People with higher levels of folate in their red blood cells were more likely to have two tumor-suppressing genes shut down by methylation, a chemical off switch for genes, researchers report in the December issue of Cancer Prevention Research. DNA hypermethylation, notes co-author Jean-Pierre Issa, M.D., professor in MD Anderson's Department of Leukemia, is found in a variety of cancers and diseases of aging, such...

2010-12-16 13:18:15

A newly published insight into the biology of many kinds of less-aggressive but still lethal brain tumors, or gliomas, opens up a wide array of possibilities for new therapies, according to scientists at Brown University and the University of California, San Francisco (UCSF). In paper published online Dec. 15 in the Journal of the National Cancer Institute, they describe how a genetic mutation leads to an abnormal metabolic process in the tumors that could be targeted by drug makers. "What...

2010-12-14 14:55:49

Ovarian cancer is the leading cause of death among gynecological cancers. To better understand the disease and improve therapies, researchers are investigating how deregulation of genes across the genome could be contributing to malignancy. In a study published online today in Genome Research (www.genome.org), scientists have identified age-related gene-specific accumulation of DNA methylation that suppresses a critical cellular pathway contributing to ovarian carcinogenesis, information that...

2010-12-14 14:36:37

There are many mechanisms that alter the activity of genes "“ direct changes to the DNA code like mutations and deletions, or changes that control when genes are switched on and off, called epigenetic means. Tumor-suppressor genes are often inactivated through epigenetics, which provides an opening for the cancerous growth of cells. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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