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Last updated on April 18, 2014 at 17:24 EDT

Latest Methylation Stories

2010-11-10 12:42:26

DNA methylation plays an important role in many processes such as animal development, X-chromosome inactivation, and carcinogenesis. Understanding the mechanisms and functions of DNA methylation and how it varies from tissue to tissue and between individuals will have profound implications for human health and disease. A team of Chinese researchers decoded the essentially complete methylome (an inventory of all the bases that are methylated) of the human genome using peripheral blood...

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2010-11-03 12:12:00

It is hard to believe that they belong to the same species: The large, long-lived queen bee is busy producing offspring throughout her lifetime. The much smaller worker bees, on the other hand, gather food, take care of the beehive, look after and feed the brood "“ but they are infertile. "The honey bee is an extreme example of different larval development," Professor Frank Lyko explains. Lyko, a scientist at DKFZ, studies how genes are regulated by chemical labeling with methyl groups....

2010-10-14 16:25:00

IPSWICH, Mass., Oct. 14 /PRNewswire/ -- New England Biolabs (NEB) has launched a suite of new and validated products designed to simplify DNA methylation analysis for epigenetics researchers. These enzyme-based solutions address some of the challenges of the current methods, including the lack of a reproducible method for the analysis and quantitation of 5-hydroxymethlcytosine (5-hmC) in the epigenome. (Logo: http://photos.prnewswire.com/prnh/20090921/NE79207LOGO-b ) (Logo:...

2010-10-14 13:51:33

A collaboration between physicians and scientists at UNC Lineberger Comprehensive Cancer Center and the University of Texas M.D. Anderson Cancer Center has demonstrated that a biomarker called TCF21 may be used to develop a potential screening test for early-stage lung cancer. Despite the fact that lung cancer is the leading cause of cancer deaths worldwide, early-stage lung cancer is difficult to diagnose. A number of proposed screening tests, including screening CT scans and serum markers,...

2010-10-11 13:16:46

For the first time, UK scientists have reported direct evidence that taking up smoking results in epigenetic changes associated with the development of cancer. The results were reported at the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy. The link between smoking and cancer has been established for decades, explained Dr Yuk Ting Ma from the Cancer Research UK Institute of Cancer Studies, Birmingham, who presented the results. Smoking is the single biggest...

2010-10-04 16:58:18

Post-translational modifications of histones play an important role in regulating chromatin dynamics and function. One such modification, methylation, is involved in the regulation of the epigenetic program of a cell, determining chromatin structure, and regulating transcription. Methylation of histones occurs on both lysine and arginine residues, and until recently, was thought to be an irreversible process. The recent discovery of histone demethylases revealed that histone methylation is...

2010-09-27 07:00:00

SYDNEY, Sept. 27 /PRNewswire/ -- Clinical Genomics Pty. Ltd (Sydney, Australia) and The Garvan Institute of Medical Research (Sydney, Australia) today announced that they have entered into a license agreement in relation to novel biomarkers discovered by scientists at the Garvan Institute. Under the terms of the agreement, Clinical Genomics obtains worldwide exclusive rights to the Garvan's proprietary cancer associated methylation DNA biomarkers for the diagnosis and or treatment of...

2010-09-20 16:32:24

Colon cancer is the second most common cancer in the United States and causes more than 50,000 deaths each year. It has been known for some time that mutations in the APC gene occur in more than 85 percent of all sporadic colon cancers. Now researchers at Huntsman Cancer Institute at the University of Utah demonstrate in a study featured today in Cell the mechanism by which mutation of the APC gene affects a cellular process known as DNA methylation. DNA methylation is a chemical modification...

2010-09-15 19:16:17

Johns Hopkins scientists who specialize in unconventional hunts for genetic information outside nuclear DNA sequences have bagged a weighty quarry "” 13 genes linked to human body mass. The experiments screened the so-called epigenome for key information that cells remember other than the DNA code itself and may have serious implications for preventing and treating obesity, the investigators say. "Some of the genes we found are in regions of the genome previously suspected but not...

2010-09-15 15:41:00

IPSWICH, Mass., Sept. 15 /PRNewswire/ -- New England Biolabs (NEB) has announced that it has received fast track SBIR funding of $1.22 million to fund the research and development of novel enzymatic reagents for epigenetic studies. (Logo: http://photos.prnewswire.com/prnh/20090921/NE79207LOGO-b ) (Logo: http://www.newscom.com/cgi-bin/prnh/20090921/NE79207LOGO-b ) New England Biolabs is committed to developing tools that advance epigenetics research and discovery, and offers a growing...