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Latest Methylation Stories

2010-12-14 14:36:37

There are many mechanisms that alter the activity of genes "“ direct changes to the DNA code like mutations and deletions, or changes that control when genes are switched on and off, called epigenetic means. Tumor-suppressor genes are often inactivated through epigenetics, which provides an opening for the cancerous growth of cells. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological...

2010-12-13 13:46:28

Researchers at Emory University School of Medicine and the University of Chicago have developed a method for labeling and mapping a "sixth nucleotide," whose biological role scientists are only beginning to explore. The method is described online this week in Nature Biotechnology. The method allowed the researchers to see for the first time how 5-hydroxymethylcytosine (5-hmC) is distributed throughout the genome. Unlike 5-methylcytosine (5-mC), a chemical modification of DNA that is generally...

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2010-11-11 10:32:03

Scientists have observed, for the first time, an intermediate stage in the chemical process that repairs DNA methylation damage and regulates many important biological functions that impact health conditions such as obesity, cancer and diabetes. The observations focused on the bacterial DNA repair protein AlkB, but the results also apply to several proteins in the same family that play key regulatory roles in humans. Armed with these results, researchers may one day develop methods for...

2010-11-10 12:42:26

DNA methylation plays an important role in many processes such as animal development, X-chromosome inactivation, and carcinogenesis. Understanding the mechanisms and functions of DNA methylation and how it varies from tissue to tissue and between individuals will have profound implications for human health and disease. A team of Chinese researchers decoded the essentially complete methylome (an inventory of all the bases that are methylated) of the human genome using peripheral blood...

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2010-11-03 12:12:00

It is hard to believe that they belong to the same species: The large, long-lived queen bee is busy producing offspring throughout her lifetime. The much smaller worker bees, on the other hand, gather food, take care of the beehive, look after and feed the brood "“ but they are infertile. "The honey bee is an extreme example of different larval development," Professor Frank Lyko explains. Lyko, a scientist at DKFZ, studies how genes are regulated by chemical labeling with methyl groups....

2010-10-14 16:25:00

IPSWICH, Mass., Oct. 14 /PRNewswire/ -- New England Biolabs (NEB) has launched a suite of new and validated products designed to simplify DNA methylation analysis for epigenetics researchers. These enzyme-based solutions address some of the challenges of the current methods, including the lack of a reproducible method for the analysis and quantitation of 5-hydroxymethlcytosine (5-hmC) in the epigenome. (Logo: http://photos.prnewswire.com/prnh/20090921/NE79207LOGO-b ) (Logo:...

2010-10-14 13:51:33

A collaboration between physicians and scientists at UNC Lineberger Comprehensive Cancer Center and the University of Texas M.D. Anderson Cancer Center has demonstrated that a biomarker called TCF21 may be used to develop a potential screening test for early-stage lung cancer. Despite the fact that lung cancer is the leading cause of cancer deaths worldwide, early-stage lung cancer is difficult to diagnose. A number of proposed screening tests, including screening CT scans and serum markers,...

2010-10-11 13:16:46

For the first time, UK scientists have reported direct evidence that taking up smoking results in epigenetic changes associated with the development of cancer. The results were reported at the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy. The link between smoking and cancer has been established for decades, explained Dr Yuk Ting Ma from the Cancer Research UK Institute of Cancer Studies, Birmingham, who presented the results. Smoking is the single biggest...

2010-10-04 16:58:18

Post-translational modifications of histones play an important role in regulating chromatin dynamics and function. One such modification, methylation, is involved in the regulation of the epigenetic program of a cell, determining chromatin structure, and regulating transcription. Methylation of histones occurs on both lysine and arginine residues, and until recently, was thought to be an irreversible process. The recent discovery of histone demethylases revealed that histone methylation is...

2010-09-27 07:00:00

SYDNEY, Sept. 27 /PRNewswire/ -- Clinical Genomics Pty. Ltd (Sydney, Australia) and The Garvan Institute of Medical Research (Sydney, Australia) today announced that they have entered into a license agreement in relation to novel biomarkers discovered by scientists at the Garvan Institute. Under the terms of the agreement, Clinical Genomics obtains worldwide exclusive rights to the Garvan's proprietary cancer associated methylation DNA biomarkers for the diagnosis and or treatment of...


Word of the Day
baudekin
  • A rich embroidered or brocaded silk fabric woven originally with a warp of gold thread.
'Baudekin' seems to be an alternative form of 'baldachin,' from the Italian 'Baldacco,' Baghdad, the city where the material was made.
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