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Latest Methylation Stories

2010-09-15 19:16:17

Johns Hopkins scientists who specialize in unconventional hunts for genetic information outside nuclear DNA sequences have bagged a weighty quarry "” 13 genes linked to human body mass. The experiments screened the so-called epigenome for key information that cells remember other than the DNA code itself and may have serious implications for preventing and treating obesity, the investigators say. "Some of the genes we found are in regions of the genome previously suspected but not...

2010-09-15 15:41:00

IPSWICH, Mass., Sept. 15 /PRNewswire/ -- New England Biolabs (NEB) has announced that it has received fast track SBIR funding of $1.22 million to fund the research and development of novel enzymatic reagents for epigenetic studies. (Logo: http://photos.prnewswire.com/prnh/20090921/NE79207LOGO-b ) (Logo: http://www.newscom.com/cgi-bin/prnh/20090921/NE79207LOGO-b ) New England Biolabs is committed to developing tools that advance epigenetics research and discovery, and offers a growing...

2010-08-17 16:49:41

Potential application for stem cell therapies Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation. The details of this collaborative study between Johns Hopkins, Stanford and Harvard appear August 15 in the early online publication of Nature. The researchers, using blood-forming...

2010-07-28 18:43:33

Grown-ups aren't the only ones making exciting scientific discoveries these days. Two middle school students from Wisconsin joined a team of scientists who are reporting the first glimpse of the innermost structure of a key bacterial enzyme. It helps activate certain antibiotics and anti-cancer agents so that those substances do their job. Their study appears in ACS' weekly journal Biochemistry. The student co-authors of the study are from Edgewood Campus Middle School in Madison and...

2010-07-12 13:50:34

Findings may lead to new drug targets A subtle mutation affecting the epigenome "“ a set of dynamic factors that influence gene activity -- may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. The disorder, which also involves cleft lip or cleft palate, appears to hinge on an enzyme working in a biological pathway that may offer several potential drug targets. The study, published online July 11 in the journal Nature,...

2010-06-29 16:01:00

NEW YORK, June 29 /PRNewswire/ -- Research experts in the epigenetic field from Epigentek have developed a new, breakthrough approach for the identification of the "sixth DNA base," 5-hydroxymethylcytosine (5-hmC). This technology is based on a high throughput, strip-well format and is also incorporated into the first commercially available product, the MethylFlash(TM) Hydroxymethylated DNA Quantification Kit (http://www.epigentek.com/hydroxymethylation), for rapidly quantifying...

2010-06-16 23:14:40

Researchers at the Stanford University School of Medicine have identified a new group of proteins involved in determining the life span of laboratory roundworms. Blocking the expression of one member of the group can extend the worm's life span by up to 30 percent. Because the proteins work in the worms' reproductive systems, the research represents yet another intriguing link between longevity and fertility. In particular, the researchers showed that the proteins are involved in epigenetics...

2010-06-08 12:42:40

Research finds similarities between pulmonary arterial hypertension and cancer A rare but fatal disease of blood vessels in the lung may be caused in part by aberrant silencing of genes rather than genetic mutation, new research reports. Pulmonary arterial hypertension, a syndrome characterized by gradual blockage of blood vessels in the lungs, has been linked to genetic causes in a small percentage of patients. But University of Chicago researchers have now found that a form of epigenetics...

2010-06-04 14:23:25

A gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells, according to researchers from the Center for Stem Cell Biology and Regenerative Medicine and the Department of Medicine at Thomas Jefferson University. In the study, published online in the journal Aging Cell, the researchers identified a protein interaction that controls the silencing of Oct4, a key transcription factor that is critical to ensuring that...

2010-06-02 16:22:23

A previously unknown pattern in DNA methylation - an event that affects cell function by altering gene expression "“ has been uncovered for the first time by stem cell researchers at UCLA, a finding that could have implications in preventing some cancers and correcting defects in human stem cell lines. The team of scientists discovered a relationship between DNA methylation and the positioning of nucleosomes, which compact and regulate access to DNA in the nucleus of a cell. The...


Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
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