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Latest Methylation Stories

2010-07-12 13:50:34

Findings may lead to new drug targets A subtle mutation affecting the epigenome "“ a set of dynamic factors that influence gene activity -- may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. The disorder, which also involves cleft lip or cleft palate, appears to hinge on an enzyme working in a biological pathway that may offer several potential drug targets. The study, published online July 11 in the journal Nature,...

2010-06-29 16:01:00

NEW YORK, June 29 /PRNewswire/ -- Research experts in the epigenetic field from Epigentek have developed a new, breakthrough approach for the identification of the "sixth DNA base," 5-hydroxymethylcytosine (5-hmC). This technology is based on a high throughput, strip-well format and is also incorporated into the first commercially available product, the MethylFlash(TM) Hydroxymethylated DNA Quantification Kit (http://www.epigentek.com/hydroxymethylation), for rapidly quantifying...

2010-06-16 23:14:40

Researchers at the Stanford University School of Medicine have identified a new group of proteins involved in determining the life span of laboratory roundworms. Blocking the expression of one member of the group can extend the worm's life span by up to 30 percent. Because the proteins work in the worms' reproductive systems, the research represents yet another intriguing link between longevity and fertility. In particular, the researchers showed that the proteins are involved in epigenetics...

2010-06-08 12:42:40

Research finds similarities between pulmonary arterial hypertension and cancer A rare but fatal disease of blood vessels in the lung may be caused in part by aberrant silencing of genes rather than genetic mutation, new research reports. Pulmonary arterial hypertension, a syndrome characterized by gradual blockage of blood vessels in the lungs, has been linked to genetic causes in a small percentage of patients. But University of Chicago researchers have now found that a form of epigenetics...

2010-06-04 14:23:25

A gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells, according to researchers from the Center for Stem Cell Biology and Regenerative Medicine and the Department of Medicine at Thomas Jefferson University. In the study, published online in the journal Aging Cell, the researchers identified a protein interaction that controls the silencing of Oct4, a key transcription factor that is critical to ensuring that...

2010-06-02 16:22:23

A previously unknown pattern in DNA methylation - an event that affects cell function by altering gene expression "“ has been uncovered for the first time by stem cell researchers at UCLA, a finding that could have implications in preventing some cancers and correcting defects in human stem cell lines. The team of scientists discovered a relationship between DNA methylation and the positioning of nucleosomes, which compact and regulate access to DNA in the nucleus of a cell. The...

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2010-05-09 13:13:12

Chemical changes in the genetic material, known as epigenetic modifications, regulate the activity of many genes. Thus, attachment of methyl groups to DNA often inactivates important cellular growth brakes. Therefore, this process called methylation is believed to be a major cause of uncontrolled division of cancer cells. Specific enzymes, the DNA methyltransferases, are responsible for methylation. Unlike changes in the blueprint of the genetic material, epigenetic mutations are reversible...

2010-04-19 07:30:00

SAN DIEGO, April 19 /PRNewswire-FirstCall/ -- Sequenom, Inc. (Nasdaq: SQNM) today announced the launch of its next-generation mass spectrometry system - the MassARRAY® Analyzer 4. This new high performance nucleic acid analysis platform has been designed to meet customer demand for a bench top instrument with greater flexibility across multiple applications, improved reliability and faster performance. With the capability for quantitative gene expression analysis,...

2010-04-18 09:51:21

DNA modification defines early onset glioblastoma, is prevalent in lower grade gliomas HOUSTON - A class of brain tumor that tends to emerge in younger patients but is less aggressive than others can be identified by examining DNA methylation of a specific set of genes, scientists at The University of Texas M. D. Anderson Cancer Center and colleagues with The Cancer Genome Atlas report today online at Cancer Cell. The national research group discovered that hypermethylation is a defining...

2010-04-16 08:26:27

Study identifies patients with longer-than-expected survival times A study conducted by a collaborative team led by researchers from the University of Southern California (USC) may lead to better insight into the clinical outcome for some patients with a particularly aggressive type of brain cancer. The research may also provide a framework for development of targeted drug treatments. The research by The Cancer Genome Atlas (TCGA), published online today in the journal Cancer Cell, used...


Word of the Day
ween
  • To think; to imagine; to fancy.
  • To be of opinion; have the notion; think; imagine; suppose.
The word 'ween' comes from Middle English wene, from Old English wēn, wēna ("hope, weening, expectation"), from Proto-Germanic *wēniz, *wēnōn (“hope, expectation”), from Proto-Indo-European *wen- (“to strive, love, want, reach, win”).
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