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Latest Methylation Stories

2010-04-08 08:51:56

A University of British Columbia doctoral candidate has discovered a previously unknown mechanism for silencing retroviruses, segments of genetic material that can lead to fatal mutations in a cell's DNA. The findings, published April 7 in the journal Nature, could lead to new cancer treatments that kill only tumor cells and leave healthy surrounding tissue unharmed. Danny Leung, a 27-year-old graduate student in the laboratory of Asst. Prof. Matthew Lorincz in the Dept. of Medical Genetics,...

2010-02-23 11:09:24

Scientists from Sydney's Garvan Institute of Medical Research have published a paper, online Feb. 22 in Nature Cell Biology, describing gene expression in a prostate cancer cell: more sweeping, more targeted and more complex than we could ever have imagined, even five years ago. The study shows that changes within the prostate cancer cell 'epigenome' (biochemical processes that target DNA and affect gene expression) alter the expression of many genes, silencing their expression within large...

2010-02-21 11:12:08

News briefing at 2010 AAAS meeting More than three million children have been born as a result of assisted reproductive technologies since the birth of the first "test tube baby" in 1978. While the majority of these children are healthy and normal, as a group they are at greater risk of certain kinds of birth defects and being low birth weight, which is associated with obesity, hypertension and type 2 diabetes later in life. Carmen Sapienza, a geneticist at Temple University School of...

2010-02-16 09:45:00

SPARTA, N.J. and LIEGE, Belgium, Feb. 16 /PRNewswire/ -- Diagenode, an innovative leader providing products and technologies for epigenetics, genomics and diagnostics, and the only provider of complete epigenetics solutions, announced today the launch of its innovative platform for automated epigenetics assays, the SX-8G IP-Star(TM) system ("IP-Star(TM)). The introduction follows the successful completion of six independent collaborations with high-profile research laboratories in the...

2010-02-13 08:29:32

Researchers from the Institute of Psychiatry (IoP), King's College London, have identified numerous novel regions of the genome where the chemical modifications involved in controlling gene expression are influenced by either genetic variation or the parental origin of that particular stretch of DNA. This contradicts previous assumptions that epigenetic signals are generally equal across both copies of a given region of the genome, except at a small number of known imprinted genes. Sequencing...

2010-02-10 08:58:28

Gastric cancer, one of the most common types of cancer, is associated with high mortality rates. In the last decades, a decrease in the worldwide incidence has been observed with some changes in the therapeutic and diagnostic options. However, the prognosis for this disease still remains poor, mainly when the diagnosis is performed at advanced stages. The therapy most effective is still surgical resection and in a significant number of cases, especially in the advanced stage, it is only...

2010-02-04 12:02:48

Billions of data points provide big picture of 'human epigenome' during critical developmental window Scientists at The Scripps Research Institute and The Genome Institute of Singapore (GIS) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development. This detailed mapping is a significant move towards the success of targeted differentiation of stem cells into specific organs, which is a crucial consideration for stem cell...

2010-02-03 22:26:38

Billions of data points provide big picture of 'human epigenome' during critical developmental window Scientists at The Genome Institute of Singapore (GIS) and The Scripps Research Institute (TSRI) led an international effort to build a map that shows in detail how the human genome is modified during embryonic development. This detailed mapping is a significant move towards the success of targeted differentiation of stem cells into specific organs, which is a crucial consideration for stem...

2010-02-03 16:48:09

Increasing numbers of research studies clearly demonstrate that genetics alone cannot explain the diversity of living organisms, reports Genetic Engineering & Biotechnology News (GEN). Also driving the development of such complexity is epigenetics, and the February 1 issue of GEN contains three articles that illustrate the growing recognition of the importance of this emerging field of study. "Scientists have shown that non-DNA-sequence-changing epigenetic phenomena such as histone...

2010-01-25 13:24:53

Researchers from the Boston University School of Medicine (BUSM) have determined how the TGFÃŽ²-Smad signaling pathway, which is over activated in late-stage cancers, is responsible for the "epigenetic memory" that maintains unique patterns of regulatory DNA hypermethylation causing silencing of critical genes that facilitate breast cancer progression. The findings, which appear online in Cancer Research, may lead to the development of new therapeutic strategies for late...


Word of the Day
omphalos
  • The navel or umbilicus.
  • In Greek archaeology: A central boss, as on a shield, a bowl, etc.
  • A sacred stone in the temple of Apollo at Delphi, believed by the Greeks to mark the 'navel' or exact center-point of the earth.
'Omphalos' comes from the ancient Greek.
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