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Latest Methylation Stories

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2009-10-15 06:25:00

Despite the fact that the human genome sequence lists nearly every single DNA base of the roughly 3 billion bases that make up a human genome, it has remained a biological mystery as to how its function is regulated. Now, scientists from the Salk Institute have revealed the first detailed map of the human epigenome, which is the network of chemical switches that regulates activation of human genes. The human genome was decoded almost 10 years ago, which plainly showed the building blocks of...

2009-10-08 09:44:16

Researchers at Henry Ford Hospital have identified tumor-suppressing genes that may provide a more accurate diagnosis of disease stage and survival for laryngeal cancer patients than current standards. The study finds genetic abnormalities of the ESR1(estrogen specific receptor 1) gene and the HIC1 (hypermethylated in cancer 1) gene are predictors of late-stage laryngeal cancer and shorter survival, respectively, for patients with the disease. Study results was presented Wednesday, Oct. 7 at...

2009-10-06 13:36:19

During cell division, whether hematopoietic stem cells (HSCs) will develop into new stem cells (self-renewal) or differentiate into other blood cells depends on a chemical process called DNA methylation. These were the findings of researchers at the laboratory of Dr. Frank Rosenbauer of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch in cooperation with the laboratory of Professor Sten Eirik W. Jacobsen (Lund University, Sweden and the University of Oxford, England)....

2009-10-05 06:10:00

A Henry Ford Hospital study has identified 231 new genes associated with head and neck cancer, one of the most deadly cancers responsible for 2.1 percent of all cancer deaths in the United States. Previously, only 33 genes were reported associated with head and neck cancer. "These new genes should advance selection of head and neck-specific gene targets, opening the door to promising new molecular strategies for the early detection and treatment of head and neck cancer," says study lead...

2009-10-05 01:30:00

LAUSANNE, Switzerland, October 5 /PRNewswire/ -- Debiopharm Group (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs, and the Japanese Cancer Association (JCA) presented 'The JCA-Mauvernay Award' to Dr Toshikazu Ushijima from the National Cancer Center Research Institute in Tokyo, for his outstanding and innovative research in basic science in the "epigenetic field for...

2009-09-30 14:00:00

NEW YORK, Sept. 30 /PRNewswire/ -- Epigentek Group Inc. today announced that it released the SuperSense(TM) Methylated DNA Quantification Kit to complete its line of methylated DNA quantification products (http://www.epigentek.com/catalog/dna-methylation-quantification-c-21_48.html). The SuperSense(TM) kit fluorometrically measures global DNA methylation shifts. This new tool complements the company's flagship product and colorimetric version of quantifying methylated DNA, the...

2009-09-21 13:27:51

Two new blood tests can aid in the early identification of patients with gastrointestinal cancers, researchers in Belgium have found. Dr. Joost Louwagie of OncoMethylome Sciences, a company in Liege, Belgium, said the scientists collected blood before surgery from 193 patients known to have colorectal cancer, as well as from 688 controls undergoing colonoscopy for cancer screening. DNA was extracted from the blood plasma and tested for the presence of DNA methylation of specific genes. DNA...

2009-09-02 07:53:22

Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institute published in Cell Metabolism. The researchers believe that these "Ëœepigenetic mutations' might have a key part to play in the development of the disease.Type II diabetes is characterized by a lower sensitivity to insulin in muscles and organs, and a reduced...

2009-08-22 11:54:06

A preliminary evaluation of methylation of two gene promoters in fecal DNA showed promise as a noninvasive method to detect colorectal and gastric cancers, according to a new study published online August 21 in the Journal of the National Cancer Institute. Because many patients are reluctant to undergo invasive tests for the detection of gastrointestinal cancers, the development of nonintrusive screening tests is desirable. Especially in cancer patients, some cells are sloughed off from the...

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2009-08-17 13:50:00

Using tiny crystals called quantum dots, Johns Hopkins researchers have developed a highly sensitive test to look for DNA attachments that often are early warning signs of cancer. This test, which detects both the presence and the quantity of certain DNA changes, could alert people who are at risk of developing the disease and could tell doctors how well a particular cancer treatment is working.The new test was reported in a paper called "MS-qFRET: a quantum dot-based method for analysis of...