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Latest Methylation Stories

2013-08-12 14:03:29

Stowers investigators show that rules governing expression of developmental genes in mouse embryonic stem cells are more nuanced than anticipated A decade ago, gene expression seemed so straightforward: genes were either switched on or off. Not both. Then in 2006, a blockbuster finding reported that developmentally regulated genes in mouse embryonic stem cells can have marks associated with both active and repressed genes, and that such genes, which were referred to as "bivalently marked...

2013-07-11 16:30:16

UBC researchers discover unusual key to regulating cell growth Researchers at the University of British Columbia have discovered a potential new pathway to treat cancer by asking some odd questions about the size of animals. "Mammals display a huge range in size from the largest blue whale to the tiniest fruit bat," says Colby Zaph, assistant professor of Pathology and Laboratory Medicine at the Biomedical Research Centre, who co-authored the study published in Developmental Cell....

Brain Epigenome Changes Through Developmental Years
2013-07-05 14:26:38

Brett Smith for redOrbit.com - Your Universe Online While the entire genome has been sequenced and the codes of many genes have been identified, there are is a wide range of unknown mechanisms that interact with the code without changing "letters" of the DNA. These chemical changes to DNA are referred to as the epigenome, and a new study in the journal Science has revealed significant epigenomic activity during brain development. DNA includes four chemical bases: adenine (A), guanine...

2013-06-18 13:14:30

Methylation refers to a chemical modification of DNA and this modification can occur in millions of positions in the DNA sequence. Until now, scientists believed that this epigenetic phenomenon actively reduced the expression of certain genes. Today, a team of researchers from the University of Geneva (UNIGE), Switzerland, led by Emmanouil Dermitzakis, Louis-Jeantet Professor at the Faculty of Medicine, reveals that this is not always the case and that DNA methylation may play both a passive...

2013-06-13 23:27:32

RiboMed Biotechnologies, Inc. (http://www.ribomed.com), a company that develops epigenetic-based tests that provide improved cancer diagnosis and allow drug therapy to be personalized for the benefit of cancer patients, today announced that it has partnered with researchers at the Austrian Institute of Technology (AIT, Vienna) to commercialize their clinically validated lung cancer DNA methylation biomarkers. Lung cancer is the number-one cause of cancer deaths in both men and women in the...

2013-06-07 12:46:23

Serum DNA analysis allows detection of early disease, say researchers in The Journal of Molecular Diagnostics The average 5-year survival for colorectal cancer (CRC) is less than 10% if metastasis occurs, but can reach 90% if detected early. A new non-invasive test has been developed that measures methylation of the SDC2 gene in tissues and blood sera. This test detected 87% of all stages of colorectal cancer cases (sensitivity) without significant difference between early and advanced...

2013-04-02 10:30:31

Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy. Their findings, published last week in Science Express, follow a recent series of discoveries by several international genome...

2013-03-22 09:31:23

Food and environment can chemically alter your gene function and scientists have identified a gene that is consistently altered in obesity. The gene LY86 was among a group of 100 genes identified as likely contributors to obesity through genome-wide association studies comparing the DNA of thousands of obese and lean individuals, said Dr. Shaoyong Su, genetic epidemiologist at the Medical College of Georgia at Georgia Regents University. Su looked at progressively larger groups of obese...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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