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Latest Methylation Stories

Bee Research Demonstrates That Behavior Could Be Genetically Altered
2012-09-17 04:08:48

redOrbit Staff & Wire Reports - Your Universe Online Genetic analysis of different types of worker bees has for the first time demonstrated a link between reversible chemical tags on an organism's DNA and their behavioral patterns. Andy Feinberg, a professor of molecular medicine and the director of the Center for Epigenetics at Hopkins' Institute for Basic Biomedical Sciences, and colleagues used a method they called CHARM (comprehensive high-throughput arrays for relative...

2012-08-27 11:45:43

Researchers show how repressor proteins ensure accurate gene expression by thwarting histone exchange Two opposing teams battle it out to regulate gene expression on the DNA playing field. One, the activators, keeps DNA open to enzymes that transcribe DNA into RNA. Their repressor opponents antagonize that effort by twisting DNA into an inaccessible coil around histone proteins, an amalgam called chromatin, effectively blocking access to DNA by enzymes that elongate an RNA strand. Both...

Why Are Chimps And Humans Genetically Different?
2012-08-24 09:45:56

April Flowers for redOrbit.com - Your Universe Online Much has been made of the fact that ninety-six percent of a chimpanzee's genome is the same as a human's. However, it is that other four percent, and the vast differences, that pique the interest of Georgia Tech's Soojin Yi. For example, why do humans have a high risk of cancer while chimps rarely develop the disease? In a new study published in September's American Journal of Human Genetics, Yi looked at brain samples from each...

2012-08-24 00:35:59

Thomas Jefferson University team shifts a longstanding paradigm for epigenetic markers It's widely accepted that molecular mechanisms mediating epigenetics include DNA methylation and histone modifications, but a team from Thomas Jefferson University has evidence to the contrary regarding the role of histone modifications. A study of Drosophila embryos from Jefferson's Department of Biochemistry and Molecular Biology published ahead of print in Cell August 23 found that parental...

2012-08-24 00:32:17

Chimpanzees rarely get cancer, or a variety of other diseases that commonly arise in humans, but their genomic DNA sequence is nearly identical to ours. So, what's their secret? Researchers reporting in the September issue of the American Journal of Human Genetics, a Cell Press journal, have found that differences in certain DNA modifications, called methylation, might play a role. The researchers discovered hundreds of genes that display different patterns of methylation between the two...

New Purpose Found For Archived Guthrie Cards
2012-08-23 07:06:49

Over the last 50 years, the spotting of newborn's blood onto filter paper for disease screening, called Guthrie cards, has become so routine that since 2000, more than 90% of newborns in the United States have had Guthrie cards created. In a study published online in Genome Research, researchers have shown that epigenetic information stored on archived Guthrie cards provides a retrospective view of the epigenome at birth, a powerful new application for the card that could help understand...

Seeds Of Defense Being Planted
2012-08-08 07:16:52

Salk study finds stress triggers widespread epigenetic changes that aid in disease resistance It was long thought that methylation, a crucial part of normal organism development, was a static modification of DNA that could not be altered by environmental conditions. New findings by researchers at the Salk Institute for Biological Studies, however, suggest that the DNA of organisms exposed to stress undergo changes in DNA methylation patterns that alter how genes are regulated. The...

2012-07-16 10:21:04

Your genes determine much about you, but environment can have a strong influence on your genes even before birth, with consequences that can last a lifetime. In a study published online in Genome Research, researchers have for the first time shown that the environment experienced in the womb defines the newborn epigenetic profile, the chemical modifications to DNA we are born with, that could have implications for disease risk later in life. Epigenetic tagging of genes by a chemical...

Immune Cell DNA Used In Diagnostic Technique
2012-07-09 17:16:37

By looking at signature chemical differences in the DNA of various immune cells called leukocytes, scientists have developed a way to determine their relative abundance in blood samples. The relative abundance turns out to correlate with specific cancers and other diseases, making the technique, described in two recent papers, potentially valuable not only for research but also for diagnostics and treatment monitoring. When a person is sick, there is a tell-tale sign in their blood: a...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.