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Latest Methylation Stories

2012-02-29 14:15:54

The domestication of chickens has given rise to rapid and extensive changes in genome function. A research team at Linköping University in Sweden has established that the changes are heritable, although they do not affect the DNA structure. Humans kept Red Junglefowl as livestock about 8000 years ago. Evolutionarily speaking, the sudden emergence of an enormous variety of domestic fowl of different colours, shapes and sizes has occurred in record time. The traditional...

2012-02-28 11:42:45

In a look at how major stressors during childhood can change a person's biological risk for psychiatric disorders, researchers at Butler Hospital have discovered a genetic alteration at the root of the association. The research, published online in PLoS ONE on January 25, 2012, suggests that childhood adversity may lead to epigenetic changes in the human glucocorticoid receptor gene, an important regulator of the biological stress response that may increase risk for psychiatric disorders....

2012-02-16 18:13:38

Writing in the February 17, 2012 issue of the journal Cell, researchers at the Ludwig Institute for Cancer Research, the University of California, San Diego School of Medicine and the Toronto Western Research Institute peel away some of the enduring mystery of how zygotes or fertilized eggs determine which copies of parental genes will be used or ignored. In developing humans and other mammals, not all genes are created equal — or equally used. The expression of certain genes, known...

2012-02-03 09:12:31

Mental illness suspect genes are among the most environmentally responsive For the first time, scientists have tracked the activity, across the lifespan, of an environmentally responsive regulatory mechanism that turns genes on and off in the brain's executive hub. Among key findings of the study by National Institutes of Health scientists: genes implicated in schizophrenia and autism turn out to be members of a select club of genes in which regulatory activity peaks during an...

2012-02-01 16:11:12

Genome Research (www.genome.org) publishes online and in print today a special issue entitled, "Cancer Genomics," highlighting insights gained form cutting-edge genomic and epigenomic analyses of cancer. Included in this special issue are novel biological insights gained from genomic analyses of pancreatic cancer, ovarian cancer, and melanoma, including, functional genomic analyses of breast cancer genes, large scale colorectal and breast cancer epigenomics, advances in methodology...

2012-01-30 10:30:04

Researchers at UC Santa Barbara have discovered a molecular pathway that may explain how a particularly deadly form of cancer develops. The discovery may lead to new cancer therapies that reprogram cells instead of killing them. The findings are published in a recent paper in the Journal of Biological Chemistry. The UCSB research team described how a certain mutation in DNA disrupts cellular function in patients with acute myeloid leukemia (AML). The researchers were prompted to study this...

2012-01-27 08:00:00

Oryzon a Biopharmaceutical company dedicated to the discovery of biomarkers and development of novel therapeutics and diagnostics announced today that Dr. Tamara Maes, will present at the 4th Annual CHI X-Gen Congress, in the CLINICAL GENOMICS. Epigenetics, Targets and Therapies: on March 5-7 March at the Hilton San Diego Resort in San Diego, California Barcelona, Spain (PRWEB) January 27, 2012 Dr. Maes's presentation will occur on March 6th at 11:00 am. Under the title “Development...

2012-01-23 13:29:45

Research team with RUB involvement reports in Genes and Development The same mechanism that stabilizes the DNA in the cell nucleus is also important for the structure and function of vertebrate muscle cells. This has been established by RUB-researchers led by Prof. Dr. Wolfgang Linke (Institute of Physiology) in cooperation with American and German colleagues. An enzyme attaches a methyl group to the protein Hsp90, which then forms a complex with the muscle protein titin. When the...

2012-01-23 10:47:41

UT MD Anderson researchers expose molecular connection between inflammation, methylation Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists at The University of Texas MD Anderson Cancer Center report today in the advance online publication of the journal Nature Medicine. The team's connection of these two separate influences eventually may lead to better combination therapies for...

2011-12-08 16:24:58

Ovarian cancer is a major health concern for women and the identification of sensitive biomarkers for early detection and/or monitoring of disease recurrence is of high clinical relevance. New work published in the Dec. 7 issue of the online journal PLoS ONE reports promising advances toward the development of blood-based DNA markers for ovarian cancer. The researchers, led by Peter W. Laird of the University of Southern California in Los Angeles, found that a DNA modification called...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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