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Latest Methyltransferase Stories

2014-05-29 10:36:33

Emory Health Sciences DNA methylation critical in model of atherosclerosis Disturbed patterns of blood flow induce lasting epigenetic changes to genes in the cells that line blood vessels, and those changes contribute to atherosclerosis, researchers have found. The findings suggest why the protective effects of good blood flow patterns, which aerobic exercise promotes, can persist over time. An epigenetic change to DNA is a chemical modification that alters whether nearby genes are...

2013-10-07 13:18:53

This press release is in support of a presentation by Dr. Daniel van den Hove on Sunday Oct. 6 at the 26th ECNP Congress in Barcelona, Spain Increasing evidence suggests that epigenetic regulation is associated with the pathogenesis of Alzheimer's disease (AD) and targeting it may one day lead to novel diagnostic and therapeutic strategies, research suggests. Scientists at The School for Mental Health and Neuroscience at Maastricht University, the Netherlands, have been performing...

2013-06-06 23:21:48

BellBrook Labs, an innovative developer of drug discovery tools, is launching four new Transzyme Methyltransferase Assay kits, which combine the company´s Transcreener HTS assay technology with Reaction Biology´s purified enzymes to provide complete methyltransferase assay solutions for inhibitor high throughput screening (HTS) and profiling. The new Transzyme Methyltransferase Assay Kits for HMTs GLP, G9a/GLP, PRMT4 (CARM1) and PRMT8, eliminate much of the costly assay development...

2013-04-02 10:30:31

Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy. Their findings, published last week in Science Express, follow a recent series of discoveries by several international genome...

2012-01-23 13:29:45

Research team with RUB involvement reports in Genes and Development The same mechanism that stabilizes the DNA in the cell nucleus is also important for the structure and function of vertebrate muscle cells. This has been established by RUB-researchers led by Prof. Dr. Wolfgang Linke (Institute of Physiology) in cooperation with American and German colleagues. An enzyme attaches a methyl group to the protein Hsp90, which then forms a complex with the muscle protein titin. When the...

2011-09-27 11:20:26

Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of Southern California (USC) have uncovered intriguing new evidence helping to explain one of the ways in which a stem cell's fate can be determined. The new data show how the "marking" of DNA sequences by groups of methyl molecules — a process called methylation — can influence the type of cell a stem cell will become. The cellular maturation process, called differentiation, has long been thought to be...

2011-08-10 18:08:19

Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain (IL-2RÃŽ³). The results, which appeared in a recent Proceedings of the National Academy of Sciences, suggest news targets for lymphoma and...

2011-04-15 00:00:28

BellBrook Labs has developed a new HTS assay for screening methyltransferases, the family of enzymes involved in epigenetic modifications that cause cancerous cell growth and metastasis. The innovative EPIGEN Methyltransferase Assay combines proprietary coupling enzymes with the detection module of the extensively validated Transcreener® HTS Assay platform to advance the discovery of new anti-cancer therapeutics. Madison, WI (PRWEB) April 14, 2011 BellBrook Labs today introduced an...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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