Latest Michael Wigler Stories
In our daily lives, clutter is something that gets in our way, something that makes it harder for us to accomplish things.
Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer types contain areas harboring multiple functionally linked genes whose loss, they posit, confers a survival advantage on growing tumors.
A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein generated by the gene FMR1, whose dysfunction causes Fragile-X syndrome.
A new study, published by Cell Press in the April 26 issue of the journal Neuron, discovers several genes associated with autism and finds evidence for a shared genetic mechanism underlying autism and fragile X syndrome, the most common genetic cause of intellectual disability.
Autism is one of the most common genetic alterations, caused by a deletion of the 27-gene cluster on chromosome 16.
Models of autism show that gene copy number controls brain structure and behavior
Three papers being published on June 9 in the journal Neuron provide new insight into the diversity of genetic abnormalities that contribute to autism.
A new method of analyzing cancerous tumors developed by scientists at Cold Spring Harbor Laboratory (CSHL) suggests that tumors may not evolve gradually, but rather in punctuated or staccato-like bursts.
Gene copy number variations of the same region, 16p11.2, are already linked to autism.
A research team led by Associate Professor Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL) has developed a sensitive and accurate way of identifying gene copy number variations (CNVs).