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Latest Michael Wigler Stories

2013-06-07 12:51:56

In our daily lives, clutter is something that gets in our way, something that makes it harder for us to accomplish things. For doctors and scientists trying to parse mountains of raw biological data, clutter is more than a nuisance; it can stand in the way of figuring out how best to treat someone who is very sick. Using increasingly cheap and rapid methods to read the billions of "letters" that comprise human genomes — including the genomes of individual cells sampled from cancerous...

2012-05-07 20:30:41

Such deletions could confer survival advantage on tumors, a challenge to '2-hit theory' of tumor suppressor action Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer types contain areas harboring multiple functionally linked genes whose loss, they posit, confers a survival advantage on growing tumors. Looking...

2012-04-25 20:19:20

A team led by scientists at Cold Spring Harbor Laboratory (CSHL) publishes research today indicating a striking association between genes found disrupted in children with autism and genes that are targets of FMRP, the protein generated by the gene FMR1, whose dysfunction causes Fragile-X syndrome. The new study appears online April 25 in the journal Neuron. Fragile-X syndrome is the most common cause of inherited intellectual disability. It is also counted among the autism spectrum...

2012-04-25 20:13:40

A new study, published by Cell Press in the April 26 issue of the journal Neuron, discovers several genes associated with autism and finds evidence for a shared genetic mechanism underlying autism and fragile X syndrome, the most common genetic cause of intellectual disability. It is well established that genetic variation caused by mutation can lead to autism spectrum disorders, and research has repeatedly implicated "de novo" (new) mutations, those that show up for the first time in...

2011-10-05 05:53:07

(Ivanhoe Newswire) — Autism is one of the most common genetic alterations, caused by a deletion of the 27-gene cluster on chromosome 16. By generating mouse models of autism, scientists at Cold Spring Harbor Laboratory (CSHL) provided the first evidence that inheriting fewer copies of these genes leads to features resembling those used to diagnose children with autism. "Children normally inherit one copy of a gene from each parent. We had the tools to see whether copy number changes...

Evidence Found For Genetic Basis Of Autism
2011-10-04 04:32:58

[ Watch the Video ] Models of autism show that gene copy number controls brain structure and behavior Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on chromosome 16 -- causes autism-like features. By generating mouse models of autism using a technique known as chromosome engineering, CSHL Professor Alea Mills and colleagues provide the first functional evidence that inheriting...

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2011-06-09 05:00:00

Three papers being published on June 9 in the journal Neuron provide new insight into the diversity of genetic abnormalities that contribute to autism. Two separate research groups searched for "copy number variants" in genetic samples from over 1,000 autism spectrum disorder (ASD) families that were recruited as part of the Simons Simplex Collection project.  The researchers compared DNA from affected and unaffected siblings using distinct versions of a sensitive and powerful genetic...

2011-03-14 14:03:27

Study of 2 breast cancer samples suggests tumors grow by 'punctuated, clonal expansions' A new method of analyzing cancerous tumors developed by scientists at Cold Spring Harbor Laboratory (CSHL) suggests that tumors may not evolve gradually, but rather in punctuated or staccato-like bursts. It is a finding that has already shed new light on the process of tumor growth and metastasis, and may help in the development of new methods to clinically evaluate tumors. The new analytic method,...

2009-10-26 15:05:31

Gene copy number variations of the same region, 16p11.2, are already linked to autism An international team of researchers led by geneticist Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL), has identified a mutation on human chromosome 16 that substantially increases risk for schizophrenia. The mutation in question is what scientists call a copy number variant (CNV). CNVs are areas of the genome where the number of copies of genes differs between individuals. The CNV is located...

2009-08-24 15:33:12

 A research team led by Associate Professor Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL) has developed a sensitive and accurate way of identifying gene copy number variations (CNVs). The method, which is described in a paper published online ahead of print in Genome Research, uses new DNA sequencing technologies to look for regions of the genome that vary in copy number between individuals in the population. Capable of detecting a wide range of different classes of...


Word of the Day
monteith
  • A large punch-bowl of the eighteenth century, usually of silver and with a movable rim, and decorated with flutings and a scalloped edge. It was also used for cooling and carrying wine-glasses.
  • A kind of cotton handkerchief having white spots on a colored ground, the spots being produced by a chemical which discharges the color.
This word is possibly named after Monteith (Monteigh), 'an eccentric 17th-century Scotsman who wore a cloak scalloped at the hem.'
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