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Latest Microglia Stories

2011-08-10 18:30:24

Animal study points to changes in brain that might help prevent cognitive decline A small amount of exercise shields older animals from memory loss following a bacterial infection, according to a study in the August 10 issue of The Journal of Neuroscience. The findings suggest moderate exercise may lead to several changes in the brain that boost its ability to protect itself during aging "” a period of increased vulnerability. In the new study, researchers led by Ruth Barrientos, PhD,...

2011-07-22 01:38:05

Specialist cells prune connections between neurons Gardeners know that some trees require regular pruning: some of their branches have to be cut so that others can grow stronger. The same is true of the developing brain: cells called microglia prune the connections between neurons, shaping how the brain is wired, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, discovered. Published online today in Science, the findings could one day help understand...

2011-06-22 09:00:00

NEW YORK, June 22, 2011 /PRNewswire-USNewswire/ -- The Alzheimer's Drug Discovery Foundation (ADDF) announced today that it has awarded a grant to Axxam SpA to develop small molecules to treat Alzheimer's disease by targeting inflammation. (Logo: http://photos.prnewswire.com/prnh/20090805/DC57332LOGO) The award will fund a drug discovery project to identify compounds that block the puringeric receptor, P2X7, which is involved in inflammation in the brain. One of the characteristic...

2011-06-10 12:25:00

Vision scientists have identified a key player in macular degeneration (MD), raising hope for a treatment for the currently incurable blinding disease. The studies reveal how light-damaged eyes invoke an out-of-control immune response, resulting in white blood cells invading the retina and leaving behind proteins that kill the light sensitive vision cells. This type of immune attack is seen in macular degeneration, which accounts for half of the vision loss cases in Australia, costing the...

2011-03-10 14:25:36

Neurodegenerative diseases like Alzheimer's and Parkinson's are partly attributable to brain inflammation. Researchers at Karolinska Institutet now demonstrate in a paper published in Nature that a well-known family of enzymes can prevent the inflammation and thus constitute a potential target for drugs. Research suggests that microglial cells - the nerve system's primary immune cells - play a critical part in neurodegenerative diseases, such as Alzheimer's and Parkinson's. The...

2011-03-07 21:42:03

Transplanting stem cells derived from umbilical cord blood cells and menstrual blood cells may offer future therapeutic benefit for those suffering from stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS), says a team of neuroscience researchers from the University of South Florida's Department of Neurosurgery and Brain Repair and collaborators from three private-sector research groups, Saneron CCEL Therapeutics, Inc., Tampa, FL, Cryo-Cell International, Inc., Oldsmar, FL,...

2011-02-11 21:08:05

Targeting the neuroinflammatory causes of Parkinson's disease with a naturally present brain chemical signal could offer a better understanding of the clinical mechanisms of the disease and open a future therapeutic window, reports a team of researchers from the University of South Florida Department Neurosurgery and Brain Repair and the James A. Haley Veterans' Administration Hospital, Tampa. Their findings are published online in the Journal of Neuroinflammation...

2011-01-26 20:36:54

USF researchers find CD45 blocks early AD developmental step in mouse model A new target for the prevention of adverse immune responses identified as factors in the development of Alzheimer's disease (AD) has been discovered by researchers at the University of South Florida's Department of Psychiatry and the Center of Excellence for Aging and Brain Repair. Their findings are published online in the Journal of Neuroscience (http://www.jneurosci.org/). The CD45 molecule is a receptor on the...

2010-11-03 17:27:09

Immune cells known as microglia, long thought to be activated in the brain only when fighting infection or injury, are constantly active and likely play a central role in one of the most basic, central phenomena in the brain "“ the creation and elimination of synapses. The findings, publishing next week in the online, open access journal PLoS Biology, catapult the humble microglia cell from its well-recognized duty of protecting the brain to direct involvement in creating the cellular...

2010-11-02 12:38:08

Once, scientists and doctors thought we were born with a certain number of neurons and those had to last us throughout our lifespan. Today, neurologists know that new neurons can be produced in adulthood. These adult hippocampal newborn neurons arise in the hippocampus, an area of the brain responsible for learning and memory. Understanding how these neurons live and die could answer questions about diseases that affect learning and memory said Dr. Amanda Sierra Saavedra, a postdoctoral...


Word of the Day
toccata
  • In music, a work for a keyboard-instrument, like the pianoforte or organ, originally intended to utilize and display varieties of touch: but the term has been extended so as to include many irregular works, similar to the prelude, the fantasia, and the improvisation.
This word is Italian in origin, coming from the feminine past participle of 'toccare,' to touch.
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