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Latest Microglia Stories

2010-10-27 14:42:55

Scientist also successfully visualises, in a living cell culture, how the immune cells colonise the brain Findings could lead to new strategies to treat various brain disorders 1. A team of international scientists led by Dr Florent Ginhoux of the Singapore Immunology Network (SIgN) of Singapore's Agency of Science, Technology and Research (A*STAR), have made a breakthrough that could lead to a better understanding of many neurodegenerative and inflammatory brain disorders. Their work,...

2010-10-23 01:38:12

Mount Sinai researchers have discovered that microglia, the immune cells that reside in the brain, have a unique origin and are formed shortly after conception. It was previously thought that microglia originated at the same time as macrophages, which are other immune cells that are thought to develop at birth. This groundbreaking discovery has the potential to lead to future treatments of degenerative brain diseases such as Alzheimer's and autoimmune diseases such as multiple sclerosis. The...

2010-10-13 14:49:01

A diet rich in the plant compound luteolin reduces age-related inflammation in the brain and related memory deficits by directly inhibiting the release of inflammatory molecules in the brain, researchers report. Luteolin (LOOT-ee-oh-lin) is found in many plants, including carrots, peppers, celery, olive oil, peppermint, rosemary and chamomile. The new study, which examined the effects of dietary luteolin in a mouse model of aging, appears in the Journal of Nutrition. The researchers focused...

2010-10-07 13:32:40

Cells that help to protect the central nervous system may also contribute to pathological changes in the brain. New research, published by Cell Press in the October 7th issue of the journal Neuron, provides mechanistic insight into a link between the immune system and neurodegenerative disorders like Alzheimer's disease that are associated with abnormal accumulation of tau protein. Tau is a protein found inside of neurons that acts almost like a skeleton, providing a supportive framework for...

2010-09-21 22:06:50

Neurological researchers at Rush University Medical Center have found a new therapeutic target that can potentially lead to a new way to prevent the progression of Alzheimer's disease. The target called neutral sphingomyelinase (N-SMase) is a protein that when activated, can cause a chain of reactions in the cell leading to neuronal death and memory loss. Results from the study funded by the National Institutes of Health and the Alzheimer's Association will be published in the September 22...

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2010-08-24 10:29:28

Scientists on August 23 reported the first evidence that eating blueberries, strawberries, and acai berries may help the aging brain stay healthy in a crucial but previously unrecognized way. Their study, presented at the 240th National Meeting of the American Chemical Society (ACS), concluded that berries, and possibly walnuts, activate the brain's natural "housekeeper" mechanism, which cleans up and recycles toxic proteins linked to age-related memory loss and other mental decline. Shibu...

2010-08-23 13:23:32

New study shows GM-CSF reduces AD pathology and eliminates memory loss A signaling protein released during rheumatoid arthritis dramatically reduced Alzheimer's disease pathology and reversed the memory impairment of mice bred to develop symptoms of the neurodegenerative disease, a new study by the University of South Florida reports. Researchers found that the protein, GM-CSF, likely stimulates the body's natural scavenger cells to attack and remove Alzheimer's amyloid deposits in the...

2010-06-15 14:13:26

Antibodies "” warrior proteins the immune system makes to defend the body against invading pathogens such as viruses and bacteria "” have a gentler side nobody knew about until now: They function not only as soldiers but also as nurses. And researchers at the Stanford University School of Medicine now think antibodies' absence in the central nervous system (the brain and spinal cord) may be a key part of the reason why nerve damage there doesn't get naturally repaired in humans....

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2010-05-28 07:38:18

Bone-marrow transplants cure mice of hair-pulling compulsion A Nobel Prize-winning University of Utah geneticist discovered that bone marrow transplants cure mutant mice who pull out their hair compulsively. The study provides the first cause-and-effect link between immune system cells and mental illness, and points toward eventual new psychiatric treatments. "We're showing there is a direct relationship between a psychiatric disorder and the immune system, specifically cells named microglia...

2010-05-27 16:55:51

Scientists earlier found that mice missing one of a group of core developmental genes known as the Hox genes developed an odd and rather unexpected pathology: the mutant animals groomed themselves compulsively to the point that they were removing their own hair and leaving self-inflicted open sores on their skin. Now, they've found a surprising connection between the Hoxb8 gene and the behavior that looks an awful lot like that of people with an obsessive compulsive spectrum disorder (OCD)....


Word of the Day
ramage
  • Boughs or branches.
  • Warbling of birds in trees.
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